4cmp - Revision history

OCA at 11:13, 9 May 2024

2024-05-09T11:13:21Z

← Older revision		Revision as of 11:13, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [https://pdbe.org/4cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [https://www.ebi.ac.uk/pdbsum/4cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [https://pdbe.org/4cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [https://www.ebi.ac.uk/pdbsum/4cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species. Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.<ref>PMID:21455174</ref> <ref>PMID:22745249</ref>		[https://www.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species. Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.<ref>PMID:21455174</ref> <ref>PMID:22745249</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:22, 14 September 2022

2022-09-14T07:22:00Z

← Older revision		Revision as of 07:22, 14 September 2022
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	<StructureSection load='4cmp' size='340' side='right'caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4cmp' size='340' side='right'caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strp1 Strp1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cmq\|4cmq]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [https://pdbe.org/4cmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [https://www.ebi.ac.uk/pdbsum/4cmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmp ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [~~http~~://pdbe.org/4cmp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cmp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species. Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.<ref>PMID:21455174</ref> <ref>PMID:22745249</ref>		[[https://www.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species. Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.<ref>PMID:21455174</ref> <ref>PMID:22745249</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[CRISPR-Cas9\|CRISPR-Cas9]]		*[[CRISPR-Cas9\|CRISPR-Cas9]]
	*[[Cas9\|Cas9]]		*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	*[[Endonuclease\|Endonuclease]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Strp1~~]]		[[Category: Streptococcus pyogenes serotype M1]]
	[[Category: Anders, C]]		[[Category: Anders C]]
	[[Category: Charpentier, E]]		[[Category: Charpentier E]]
	[[Category: Doudna~~, J A~~]]		[[Category: Doudna JA]]
	[[Category: Hauer, M]]		[[Category: Hauer M]]
	[[Category: Iavarone~~, A T~~]]		[[Category: Iavarone AT]]
	[[Category: Jiang, F]]		[[Category: Jiang F]]
	[[Category: Jinek, M]]		[[Category: Jinek M]]
	[[Category: Kaplan, M]]		[[Category: Kaplan M]]
	[[Category: Kaya, E]]		[[Category: Kaya E]]
	[[Category: Lin, S]]		[[Category: Lin S]]
	[[Category: Ma, E]]		[[Category: Ma E]]
	[[Category: Nogales, E]]		[[Category: Nogales E]]
	[[Category: Sternberg~~, S H~~]]		[[Category: Sternberg SH]]
	[[Category: Taylor~~, D W~~]]		[[Category: Taylor DW]]
	[[Category: Zhou, K]]		[[Category: Zhou K]]
	~~[[Category: Crrna]]~~
	~~[[Category: Dnase]]~~
	~~[[Category: Genome editing]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Immunity]]~~
	~~[[Category: Rna-guided~~]]

OCA at 09:26, 20 March 2019

2019-03-20T09:26:44Z

← Older revision		Revision as of 09:26, 20 March 2019
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	==Crystal structure of S. pyogenes Cas9==		==Crystal structure of S. pyogenes Cas9==
	<StructureSection load='4cmp' size='340' side='right' caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4cmp' size='340' side='right'caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp1 Strp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp1 Strp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CMP FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
			*[[CRISPR-Cas9\|CRISPR-Cas9]]
	*[[Cas9\|Cas9]]		*[[Cas9\|Cas9]]
	*[[Endonuclease\|Endonuclease]]		*[[Endonuclease\|Endonuclease]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Strp1]]		[[Category: Strp1]]
	[[Category: Anders, C]]		[[Category: Anders, C]]

OCA at 21:56, 4 August 2016

2016-08-04T21:56:49Z

← Older revision		Revision as of 21:56, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of S. pyogenes Cas9==		==Crystal structure of S. pyogenes Cas9==
	<StructureSection load='4cmp' size='340' side='right' caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4cmp' size='340' side='right' caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cmq\|4cmq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cmq\|4cmq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [http://www.ebi.ac.uk/pdbsum/4cmp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [http://pdbe.org/4cmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [http://www.ebi.ac.uk/pdbsum/4cmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4cmp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:28, 25 December 2014

2014-12-25T13:28:29Z

← Older revision		Revision as of 13:28, 25 December 2014
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	~~{{STRUCTURE_4cmp~~\| ~~PDB~~=4cmp \| ~~SCENE~~= }}		==Crystal structure of S. pyogenes Cas9==
	===~~Crystal structure~~ of S. ~~pyogenes~~ Cas9===		<StructureSection load='4cmp' size='340' side='right' caption='[[4cmp]], [[Resolution\|resolution]] 2.62Å' scene=''>
	~~{{ABSTRACT_PUBMED_24505130}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4cmp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp1 Strp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CMP FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cmq\|4cmq]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cmp RCSB], [http://www.ebi.ac.uk/pdbsum/4cmp PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species. Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.<ref>PMID:21455174</ref> <ref>PMID:22745249</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Type II CRISPR-Cas systems use an RNA-guided DNA endonuclease, Cas9, to generate double-strand breaks in invasive DNA during an adaptive bacterial immune response. Cas9 has been harnessed as a powerful tool for genome editing and gene regulation in many eukaryotic organisms. Here, we report 2.6 and 2.2 A resolution crystal structures of two major Cas9 enzymes subtypes, revealing the structural core shared by all Cas9 family members. The architectures of Cas9 enzymes define nucleic acid binding clefts, and single-particle electron microscopy reconstructions show that the two structural lobes harboring these clefts undergo guide RNA-induced reorientation to form a central channel where DNA substrates are bound. The observation that extensive structural rearrangements occur before target DNA duplex binding implicates guide RNA loading as a key step in Cas9 activation.

	~~==Function==~~		Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.,Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA Science. 2014 Feb 6. PMID:24505130<ref>PMID:24505130</ref>
	~~[[http://www~~.uniprot.org/uniprot/CAS9_STRP1 CAS9_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, ~~transposable elements and conjugative plasmids). CRISPR clusters contain spacers~~, ~~sequences complementary to antecedent mobile elements~~, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, ~~then trimmed by 3'-5' exonucleolytically. DNA-binding requires protein and both RNA species~~. ~~Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself~~.~~<ref>~~PMID:~~21455174</ref>~~ <ref>PMID:~~22745249~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4cmp]] is~~ a ~~2 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=4CMP OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:024505130</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Cas9\|Cas9]]
	[[Category: Anders, C.]]		*[[Endonuclease\|Endonuclease]]
	[[Category: Charpentier, E.]]		== References ==
	[[Category: Doudna, J A.]]		<references/>
	[[Category: Hauer, M.]]		__TOC__
	[[Category: Iavarone, A T.]]		</StructureSection>
	[[Category: Jiang, F.]]		[[Category: Strp1]]
	[[Category: Jinek, M.]]		[[Category: Anders, C]]
	[[Category: Kaplan, M.]]		[[Category: Charpentier, E]]
	[[Category: Kaya, E.]]		[[Category: Doudna, J A]]
	[[Category: Lin, S.]]		[[Category: Hauer, M]]
	[[Category: Ma, E.]]		[[Category: Iavarone, A T]]
	[[Category: Nogales, E.]]		[[Category: Jiang, F]]
	[[Category: Sternberg, S H.]]		[[Category: Jinek, M]]
	[[Category: Taylor, D W.]]		[[Category: Kaplan, M]]
	[[Category: Zhou, K.]]		[[Category: Kaya, E]]
			[[Category: Lin, S]]
			[[Category: Ma, E]]
			[[Category: Nogales, E]]
			[[Category: Sternberg, S H]]
			[[Category: Taylor, D W]]
			[[Category: Zhou, K]]
	[[Category: Crrna]]		[[Category: Crrna]]
	[[Category: Dnase]]		[[Category: Dnase]]

OCA at 14:14, 19 February 2014

2014-02-19T14:14:57Z

← Older revision		Revision as of 14:14, 19 February 2014
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	{{STRUCTURE_4cmp\| PDB=4cmp \| SCENE= }}		{{STRUCTURE_4cmp\| PDB=4cmp \| SCENE= }}
	===Crystal structure of S. pyogenes Cas9===		===Crystal structure of S. pyogenes Cas9===
			{{ABSTRACT_PUBMED_24505130}}

	==Function==		==Function==
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	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:024505130</ref><references group="xtra"/><references/>
	[[Category: Anders, C.]]		[[Category: Anders, C.]]
	[[Category: Charpentier, E.]]		[[Category: Charpentier, E.]]

OCA at 05:15, 13 February 2014

2014-02-13T05:15:45Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4cmp|  PDB=4cmp  |  SCENE=  }}
-The entry 4cmp is ON HOLD  until Paper Publication
+==Function==
-Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.
+==About this Structure==
-Description: Crystal structure of S. pyogenes Cas9
+==Reference==

OCA at 09:44, 5 February 2014

2014-02-05T09:44:57Z

← Older revision		Revision as of 09:44, 5 February 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4cmp is ON HOLD		The entry 4cmp is ON HOLD until Paper Publication

	Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.		Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.

	Description: Crystal structure of S. pyogenes Cas9		Description: Crystal structure of S. pyogenes Cas9

OCA: Protected "4cmp" [edit=sysop:move=sysop]

2014-01-22T06:40:21Z

Protected "4cmp" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:40, 22 January 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4cmp is ON HOLD Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M....

2014-01-22T06:40:20Z

New page: '''Unreleased structure''' The entry 4cmp is ON HOLD Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M....

New page

'''Unreleased structure'''

The entry 4cmp is ON HOLD

Authors: Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.

Description: Crystal structure of S. pyogenes Cas9