4d2a - Revision history

OCA: Redirecting to 4ctg

2014-12-10T15:42:59Z

Redirecting to 4ctg

← Older revision		Revision as of 15:42, 10 December 2014
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	~~==The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle==~~		#REDIRECT [[4ctg]] This PDB entry is obsolete and replaced by 4ctg
	~~<StructureSection load='4d2a' size='340' side='right' caption='~~[[~~4d2a]], [[Resolution\|resolution]] 17.00Å' scene=''>~~
	~~== Structural highlights ==~~
	~~<table><tr><td colspan='2'>[[4d2a~~]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_rhinitis_a_virus Equine rhinitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D2A FirstGlance]. <br>
	~~</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d14\|4d14]], [[4d15\|4d15]], [[4d16\|4d16]], [[4ctg\|4ctg]]</td></tr>~~
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d2a RCSB], [http://www.ebi.ac.uk/pdbsum/4d2a PDBsum]</span></td></tr>
	~~<table>~~
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	~~The Picornaviridae family of small, nonenveloped viruses includes major pathogens of humans and animals. They have positive-sense, single-stranded RNA genomes,~~ and ~~the mechanism(s)~~ by which these genomes are introduced into cells to initiate infection remains poorly understood. The structures of presumed uncoating intermediate particles of several picornaviruses show limited expansion and some increased porosity compared to the mature virions. Here, we present the cryo-electron microscopy structure of native equine rhinitis A virus (ERAV), together with the structure of a massively expanded ERAV particle, each at approximately 17-A resolution. The expanded structure has large pores on the particle 3-fold axes and has lost the RNA genome and the capsid protein VP4. The expanded structure thus illustrates both the limits of structural plasticity in such capsids and a plausible route by which genomic RNA might exit. IMPORTANCE: Picornaviruses are important animal and human pathogens that protect their genomic RNAs within a protective protein capsid. Upon infection, this genomic RNA must be able to leave the capsid to initiate a new round of infection. We describe here the structure of a unique, massively expanded state of equine rhinitis A virus that provides insight into how this exit might occur.

	Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis a virus particle.,Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19. PMID:24648455<ref>PMID:24648455</ref>

	~~From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~== References ==~~
	~~<references/>~~
	~~__TOC__~~
	~~</StructureSection>~~
	~~[[Category: Equine rhinitis a virus]]~~
	~~[[Category: Bakker, S E.]]~~
	~~[[Category: Groppelli, E.]]~~
	~~[[Category: Pearson, A R.]]~~
	~~[[Category: Ranson, N A.]]~~
	~~[[Category: Rowlands, D J.]]~~
	~~[[Category: Stockley, P G.]]~~
	~~[[Category: Capsid expansion]]~~
	~~[[Category: Capsid structure]]~~
	~~[[Category: Picornavirus]]~~
	~~[[Category: Uncoating]]~~
	~~[[Category: Virus]]~~

OCA at 09:07, 21 May 2014

2014-05-21T09:07:38Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle==
-The entry 4d2a is ON HOLD
+Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis a virus particle.,Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19. PMID:24648455<ref>PMID:24648455</ref>
-Authors: Bakker, S.E., Groppelli, E., Pearson, A.R., Stockley, P.G., Rowlands, D.J., Ranson, N.A.
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle
+== References ==

OCA: Protected "4d2a" [edit=sysop:move=sysop]

2014-05-14T07:02:52Z

Protected "4d2a" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:02, 14 May 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4d2a is ON HOLD Authors: Bakker, S.E., Groppelli, E., Pearson, A.R., Stockley, P.G., Rowlands, D.J., Ranson, N.A. Description: The limits of struct...

2014-05-14T07:02:51Z

New page: '''Unreleased structure''' The entry 4d2a is ON HOLD Authors: Bakker, S.E., Groppelli, E., Pearson, A.R., Stockley, P.G., Rowlands, D.J., Ranson, N.A. Description: The limits of struct...

New page

'''Unreleased structure'''

The entry 4d2a is ON HOLD

Authors: Bakker, S.E., Groppelli, E., Pearson, A.R., Stockley, P.G., Rowlands, D.J., Ranson, N.A.

Description: The limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle