4dff - Revision history

OCA at 09:55, 30 October 2024

2024-10-30T09:55:43Z

← Older revision		Revision as of 09:55, 30 October 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [https://pdbe.org/4dff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [https://www.ebi.ac.uk/pdbsum/4dff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [https://pdbe.org/4dff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [https://www.ebi.ac.uk/pdbsum/4dff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>		[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:15, 21 September 2022

2022-09-21T08:15:44Z

← Older revision		Revision as of 08:15, 21 September 2022
Line 1:		Line 1:

	==The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia==		==The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia==
	<StructureSection load='4dff' size='340' side='right' caption='[[4dff]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4dff' size='340' side='right'caption='[[4dff]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [https://pdbe.org/4dff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [https://www.ebi.ac.uk/pdbsum/4dff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dff ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [~~http~~://pdbe.org/4dff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>		[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Bercovici, A]]		[[Category: Large Structures]]
	[[Category: Bleichardt, C]]		[[Category: Bercovici A]]
	[[Category: Greenlee~~, W J~~]]		[[Category: Bleichardt C]]
	[[Category: Guzzi, M]]		[[Category: Greenlee WJ]]
	[[Category: Ho~~, G D~~]]		[[Category: Guzzi M]]
	[[Category: Hodgson, R]]		[[Category: Ho GD]]
	[[Category: Hruza, A]]		[[Category: Hodgson R]]
	[[Category: Mullins, D]]		[[Category: Hruza A]]
	~~[[Category: Rijn, R Van~~]]		[[Category: Mullins D]]
	[[Category: Rindgen, D]]		[[Category: Rindgen D]]
	[[Category: Seganish~~, W M~~]]		[[Category: Seganish WM]]
	[[Category: Tulshian, D]]		[[Category: Tulshian D]]
	[[Category: ~~Xiao, L~~]]		[[Category: Van Rijn R]]
	[[Category: ~~Zhang, X~~]]		[[Category: Xiao L]]
	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~		[[Category: Zhang X]]
	~~[[Category: Mg binding]]~~
	~~[[Category: Zn binding~~]]

OCA at 08:01, 5 August 2016

2016-08-05T08:01:01Z

← Older revision		Revision as of 08:01, 5 August 2016
Line 1:		Line 1:

	==The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia==		==The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia==
	<StructureSection load='4dff' size='340' side='right' caption='[[4dff]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4dff' size='340' side='right' caption='[[4dff]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [http://www.ebi.ac.uk/pdbsum/4dff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [http://pdbe.org/4dff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [http://www.ebi.ac.uk/pdbsum/4dff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4dff" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bercovici, A]]		[[Category: Bercovici, A]]
	[[Category: Bleichardt, C]]		[[Category: Bleichardt, C]]

OCA at 17:06, 25 December 2014

2014-12-25T17:06:25Z

← Older revision		Revision as of 17:06, 25 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4dff~~.~~png~~\|~~left~~\|~~200px~~]]		==The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia==
			<StructureSection load='4dff' size='340' side='right' caption='[[4dff]], [[Resolution\|resolution]] 2.11Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4dff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFF FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JP:8,9-DIMETHOXY-1-(1,3-THIAZOL-5-YL)-5,6-DIHYDROIMIDAZO[5,1-A]ISOQUINOLINE'>0JP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dff RCSB], [http://www.ebi.ac.uk/pdbsum/4dff PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The identification of potent and orally active dihydroimidazoisoquinolines as PDE 10A inhibitors is reported. The SAR development led to the discovery of compound 35 as a potent, selective, and orally active PDE10A inhibitor. Compound 35 inhibited MK-801-induced hyperactivity at 3mg/kg and displayed a 10-fold separation between the minimal effective doses for inhibition of MK-801-induced hyperactivity and hypolocomotion in rats.

	~~<!--~~		The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.,Ho GD, Michael Seganish W, Bercovici A, Tulshian D, Greenlee WJ, Van Rijn R, Hruza A, Xiao L, Rindgen D, Mullins D, Guzzi M, Zhang X, Bleickardt C, Hodgson R Bioorg Med Chem Lett. 2012 Feb 9. PMID:22377514<ref>PMID:22377514</ref>
	The ~~line below this paragraph~~, ~~containing "STRUCTURE_4dff"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_4dff\| PDB=4dff \| SCENE= }}~~

	~~===The SAR development~~ of ~~dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for~~ the ~~treatment~~ of ~~schizophrenia===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
	~~<!--~~		*[[Phosphodiesterase\|Phosphodiesterase]]
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22377514}}, adds the Publication Abstract to the page~~		== References ==
	~~(as it appears on PubMed at http://www.pubmed.gov), where 22377514 is the PubMed ID number.~~		<references/>
	~~-->~~		__TOC__
	~~{{ABSTRACT_PUBMED_22377514}}~~		</StructureSection>

	==~~About this Structure~~==
	[[~~4dff]~~] ~~is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFF OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022377514<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bercovici, A.]]		[[Category: Bercovici, A]]
	[[Category: Bleichardt, C.]]		[[Category: Bleichardt, C]]
	[[Category: Greenlee, W J.]]		[[Category: Greenlee, W J]]
	[[Category: Guzzi, M.]]		[[Category: Guzzi, M]]
	[[Category: Ho, G D.]]		[[Category: Ho, G D]]
	[[Category: Hodgson, R.]]		[[Category: Hodgson, R]]
	[[Category: Hruza, A.]]		[[Category: Hruza, A]]
	[[Category: Mullins, D.]]		[[Category: Mullins, D]]
	[[Category: Rijn, R Van.]]		[[Category: Rijn, R Van]]
	[[Category: Rindgen, D.]]		[[Category: Rindgen, D]]
	[[Category: Seganish, W M.]]		[[Category: Seganish, W M]]
	[[Category: Tulshian, D.]]		[[Category: Tulshian, D]]
	[[Category: Xiao, L.]]		[[Category: Xiao, L]]
	[[Category: Zhang, X.]]		[[Category: Zhang, X]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Mg binding]]		[[Category: Mg binding]]
	[[Category: Zn binding]]		[[Category: Zn binding]]

OCA at 05:10, 4 April 2012

2012-04-04T05:10:27Z

← Older revision		Revision as of 05:10, 4 April 2012
Line 1:		Line 1:
	[[Image:4dff.~~jpg~~\|left\|200px]]		[[Image:4dff.png\|left\|200px]]

	<!--		<!--

OCA at 06:32, 14 March 2012

2012-03-14T06:32:35Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4dff.jpg|left|200px]]
-The entry 4dff is ON HOLD
+<!--
-Authors: Ho, G.D., Seganish, W.M., Bercovici, A., Tulshian, D., Greenlee, W.J., Van Rijn, R., Hruza, A., Xiao, L., Rindgen, D., Mullins, D., Guzzi, M., Zhang, X., Bleichardt, C., Hodgson, R.
+===The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia===
-Description: The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia

OCA: Protected "4dff" [edit=sysop:move=sysop]

2012-02-01T07:02:31Z

Protected "4dff" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:02, 1 February 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4dff is ON HOLD Authors: Ho, G.D., Seganish, W.M., Bercovici, A., Tulshian, D., Greenlee, W.J., Van Rijn, R., Hruza, A., Xiao, L., Rindgen, D., Mull...

2012-02-01T07:02:28Z

New page: '''Unreleased structure''' The entry 4dff is ON HOLD Authors: Ho, G.D., Seganish, W.M., Bercovici, A., Tulshian, D., Greenlee, W.J., Van Rijn, R., Hruza, A., Xiao, L., Rindgen, D., Mull...

New page

'''Unreleased structure'''

The entry 4dff is ON HOLD

Authors: Ho, G.D., Seganish, W.M., Bercovici, A., Tulshian, D., Greenlee, W.J., Van Rijn, R., Hruza, A., Xiao, L., Rindgen, D., Mullins, D., Guzzi, M., Zhang, X., Bleichardt, C., Hodgson, R.

Description: The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia