4dk2 - Revision history

OCA at 14:36, 14 March 2024

2024-03-14T14:36:57Z

← Older revision		Revision as of 14:36, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [https://pdbe.org/4dk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [https://pdbe.org/4dk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]]		[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The Tritryps Trypanosoma brucei, T. cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-a NTP pyrophosphohydrolase family and represent promising drug targets due to their essential nature and markedly different structural and biochemical properties compared to the trimeric human enzyme. Here we present the structure of the T. brucei enzyme in open and closed conformations. Furthermore, we probe the reaction mechanism through the binding of transition state mimics both in solution and in the crystal. 31P-NMR and tryptophan fluorescence quenching in the presence of AlF3 and MgF3- identified which phosphate is subject to nucleophilic attack by a water molecule. The structures in complex with two transition state analogues confirm that the nucleophilic attack occurs on the b-phosphate in contrast to the a-phosphate in the trimeric enzymes. These results establish the structural basis of catalysis of these important house-keeping enzymes and has ramifications for the wider all-a NTP pyrophosphohydrolase family.

	~~On the catalytic mechanism of dimeric dUTPases.,Hemsworth GR, Gonzalez-Pacanowska D, Wilson KS Biochem J. 2013 Sep 4. PMID:24001052<ref>PMID:24001052</ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4dk2" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:22, 21 September 2022

2022-09-21T08:22:28Z

← Older revision		Revision as of 08:22, 21 September 2022
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	==Crystal Structure of Open Trypanosoma brucei dUTPase==		==Crystal Structure of Open Trypanosoma brucei dUTPase==
	<StructureSection load='4dk2' size='340' side='right' caption='[[4dk2]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='4dk2' size='340' side='right'caption='[[4dk2]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk4\|4dk4]], [[4dkb\|4dkb]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [https://pdbe.org/4dk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk2 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [~~http~~://pdbe.org/4dk2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dk2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~DUTP diphosphatase~~]]		[[Category: Large Structures]]
	[[Category: ~~Gonzalez-Pacanowska, D~~]]		[[Category: Trypanosoma brucei]]
	[[Category: ~~Hemsworth, G R~~]]		[[Category: Gonzalez-Pacanowska D]]
	[[Category: ~~Wilson, K S~~]]		[[Category: Hemsworth GR]]
	[[Category: ~~All alpha ntp pyrophosphatase]]~~		[[Category: Wilson KS]]
	~~[[Category: All alpha ntp pyrophosphohydrolase]]~~
	~~[[Category: Dutp and mg2+ binding]]~~
	~~[[Category: Hydrolase~~]]

OCA at 07:23, 4 August 2016

2016-08-04T07:23:24Z

← Older revision		Revision as of 07:23, 4 August 2016
Line 1:		Line 1:

	==Crystal Structure of Open Trypanosoma brucei dUTPase==		==Crystal Structure of Open Trypanosoma brucei dUTPase==
	<StructureSection load='4dk2' size='340' side='right' caption='[[4dk2]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='4dk2' size='340' side='right' caption='[[4dk2]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk4\|4dk4]], [[4dkb\|4dkb]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk4\|4dk4]], [[4dkb\|4dkb]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4dk2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [http://pdbe.org/4dk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4dk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4dk2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Trypanosoma brucei]]~~
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
	[[Category: Gonzalez-Pacanowska, D]]		[[Category: Gonzalez-Pacanowska, D]]

OCA at 08:55, 21 December 2014

2014-12-21T08:55:10Z

← Older revision		Revision as of 08:55, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4dk2~~\| ~~PDB~~=4dk2 \| ~~SCENE~~= }}		==Crystal Structure of Open Trypanosoma brucei dUTPase==
	===~~Crystal Structure of Open~~ Trypanosoma brucei ~~dUTPase~~===		<StructureSection load='4dk2' size='340' side='right' caption='[[4dk2]], [[Resolution\|resolution]] 1.47Å' scene=''>
	~~{{ABSTRACT_PUBMED_24001052}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DK2 FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk4\|4dk4]], [[4dkb\|4dkb]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4dk2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Tritryps Trypanosoma brucei, T. cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-a NTP pyrophosphohydrolase family and represent promising drug targets due to their essential nature and markedly different structural and biochemical properties compared to the trimeric human enzyme. Here we present the structure of the T. brucei enzyme in open and closed conformations. Furthermore, we probe the reaction mechanism through the binding of transition state mimics both in solution and in the crystal. 31P-NMR and tryptophan fluorescence quenching in the presence of AlF3 and MgF3- identified which phosphate is subject to nucleophilic attack by a water molecule. The structures in complex with two transition state analogues confirm that the nucleophilic attack occurs on the b-phosphate in contrast to the a-phosphate in the trimeric enzymes. These results establish the structural basis of catalysis of these important house-keeping enzymes and has ramifications for the wider all-a NTP pyrophosphohydrolase family.

	~~==About this Structure==~~		On the catalytic mechanism of dimeric dUTPases.,Hemsworth GR, Gonzalez-Pacanowska D, Wilson KS Biochem J. 2013 Sep 4. PMID:24001052<ref>PMID:24001052</ref>
	~~[[4dk2]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei Trypanosoma brucei]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024001052</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
	[[Category: Gonzalez-Pacanowska, D.]]		[[Category: Gonzalez-Pacanowska, D]]
	[[Category: Hemsworth, G R.]]		[[Category: Hemsworth, G R]]
	[[Category: Wilson, K S.]]		[[Category: Wilson, K S]]
	[[Category: All alpha ntp pyrophosphatase]]		[[Category: All alpha ntp pyrophosphatase]]
	[[Category: All alpha ntp pyrophosphohydrolase]]		[[Category: All alpha ntp pyrophosphohydrolase]]
	[[Category: Dutp and mg2+ binding]]		[[Category: Dutp and mg2+ binding]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 02:52, 20 September 2013

2013-09-20T02:52:48Z

← Older revision		Revision as of 02:52, 20 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4dk2\| PDB=4dk2 \| SCENE= }}		{{STRUCTURE_4dk2\| PDB=4dk2 \| SCENE= }}
	===Crystal Structure of Open Trypanosoma brucei dUTPase===		===Crystal Structure of Open Trypanosoma brucei dUTPase===
			{{ABSTRACT_PUBMED_24001052}}

	==About this Structure==		==About this Structure==
	[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA].		[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA].

			==Reference==
			<ref group="xtra">PMID:024001052</ref><references group="xtra"/><references/>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]

OCA at 20:59, 7 August 2013

2013-08-07T20:59:22Z

← Older revision		Revision as of 20:59, 7 August 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4dk2\| PDB=4dk2 \| SCENE= }}
			===Crystal Structure of Open Trypanosoma brucei dUTPase===

	~~The entry~~ 4dk2 is ~~ON HOLD until Aug 04 2014~~		==About this Structure==
			[[4dk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK2 OCA].
	~~Authors~~: ~~Hemsworth, G.R.,~~ Gonzalez-Pacanowska, D., Wilson, K.S.		[[Category: Trypanosoma brucei]]
			[[Category: DUTP diphosphatase]]
	~~Description~~: ~~Crystal Structure of Open Trypanosoma brucei dUTPase~~		[[Category: Gonzalez-Pacanowska, D.]]
			[[Category: Hemsworth, G R.]]
			[[Category: Wilson, K S.]]
			[[Category: All alpha ntp pyrophosphatase]]
			[[Category: All alpha ntp pyrophosphohydrolase]]
			[[Category: Dutp and mg2+ binding]]
			[[Category: Hydrolase]]

OCA at 10:52, 19 December 2012

2012-12-19T10:52:20Z

← Older revision		Revision as of 10:52, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4dk2 is ON HOLD until ~~Paper Publication~~		The entry 4dk2 is ON HOLD until Aug 04 2014

	Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.		Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.

	Description: Crystal Structure of Open Trypanosoma brucei dUTPase		Description: Crystal Structure of Open Trypanosoma brucei dUTPase

OCA: Protected "4dk2" [edit=sysop:move=sysop]

2012-02-15T06:21:45Z

Protected "4dk2" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:21, 15 February 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4dk2 is ON HOLD until Paper Publication Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S. Description: Crystal Structure of Open Tryp...

2012-02-15T06:21:44Z

New page: '''Unreleased structure''' The entry 4dk2 is ON HOLD until Paper Publication Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S. Description: Crystal Structure of Open Tryp...

New page

'''Unreleased structure'''

The entry 4dk2 is ON HOLD until Paper Publication

Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.

Description: Crystal Structure of Open Trypanosoma brucei dUTPase