4dpr - Revision history

OCA at 14:41, 14 March 2024

2024-03-14T14:41:49Z

← Older revision		Revision as of 14:41, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.02Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [https://pdbe.org/4dpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [https://www.ebi.ac.uk/pdbsum/4dpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [https://pdbe.org/4dpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [https://www.ebi.ac.uk/pdbsum/4dpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Human leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzyme that converts the highly unstable epoxide intermediate LTA4 into LTB4, a potent leukocyte activating agent, while the aminopeptidase activity cleaves and inactivates the chemotactic tripeptide Pro-Gly-Pro. Here, we describe high-resolution crystal structures of LTA4H complexed with LTA4, providing the structural underpinnings of the enzyme's unique epoxide hydrolase (EH) activity, involving Zn2+, Y383, E271, D375, and two catalytic waters. The structures reveal that a single catalytic water is involved in both catalytic activities of LTA4H, alternating between epoxide ring opening and peptide bond hydrolysis, assisted by E271 and E296, respectively. Moreover, we have found two conformations of LTA4H, uncovering significant domain movements. The resulting structural alterations indicate that LTA4 entrance into the active site is a dynamic process that includes rearrangement of three moving domains to provide fast and efficient alignment and processing of the substrate. Thus, the movement of one dynamic domain widens the active site entrance, while another domain acts like a lid, opening and closing access to the hydrophobic tunnel, which accommodates the aliphatic tale of LTA4 during EH reaction. The enzyme-LTA4 complex structures and dynamic domain movements provide critical insights for development of drugs targeting LTA4H.

	Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.,Stsiapanava A, Samuelsson B, Haeggstrom JZ Proc Natl Acad Sci U S A. 2017 Aug 21. pii: 201710850. doi:, 10.1073/pnas.1710850114. PMID:28827365<ref>PMID:28827365</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4dpr" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==

OCA at 08:33, 21 September 2022

2022-09-21T08:33:41Z

← Older revision		Revision as of 08:33, 21 September 2022
Line 1:		Line 1:

	==Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril==		==Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril==
	<StructureSection load='4dpr' size='340' side='right' caption='[[4dpr]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='4dpr' size='340' side='right'caption='[[4dpr]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [https://pdbe.org/4dpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [https://www.ebi.ac.uk/pdbsum/4dpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpr ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [~~http~~://pdbe.org/4dpr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dpr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Haeggstrom, J Z~~]]		[[Category: Large Structures]]
	[[Category: ~~Rinaldo-Matthis, A~~]]		[[Category: Haeggstrom JZ]]
	[[Category: ~~Stsiapanava,~~ A]]		[[Category: Rinaldo-Matthis A]]
	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~		[[Category: Stsiapanava A]]
	~~[[Category: Leukotriene a4]]~~
	~~[[Category: Metalloprotein]]~~
	~~[[Category: Protease]]~~
	~~[[Category: Zinc binding~~]]

OCA at 05:43, 25 April 2018

2018-04-25T05:43:45Z

@@ Line 11: / Line 11: @@
 == Function ==
 [[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
 == References ==
 <references/>

OCA at 07:55, 15 November 2017

2017-11-15T07:55:54Z

← Older revision		Revision as of 07:55, 15 November 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>

	~~==See Also==~~
	*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:39, 5 August 2016

2016-08-05T16:39:03Z

← Older revision		Revision as of 16:39, 5 August 2016
Line 1:		Line 1:

	==Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril==		==Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril==
	<StructureSection load='4dpr' size='340' side='right' caption='[[4dpr]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='4dpr' size='340' side='right' caption='[[4dpr]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DPR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [http://www.ebi.ac.uk/pdbsum/4dpr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [http://pdbe.org/4dpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [http://www.ebi.ac.uk/pdbsum/4dpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dpr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Haeggstrom, J Z]]		[[Category: Haeggstrom, J Z]]
	[[Category: Rinaldo-Matthis, A]]		[[Category: Rinaldo-Matthis, A]]

OCA at 04:04, 25 December 2014

2014-12-25T04:04:45Z

← Older revision		Revision as of 04:04, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [http://www.ebi.ac.uk/pdbsum/4dpr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [http://www.ebi.ac.uk/pdbsum/4dpr PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>

	==See Also==		==See Also==
	*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]		*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:03, 9 December 2014

2014-12-09T16:03:45Z

← Older revision		Revision as of 16:03, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4dpr~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril==
			<StructureSection load='4dpr' size='340' side='right' caption='[[4dpr]], [[Resolution\|resolution]] 2.02Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4dpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DPR FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dpr RCSB], [http://www.ebi.ac.uk/pdbsum/4dpr PDBsum]</span></td></tr>
			</table>

	~~{{STRUCTURE_4dpr\| PDB=4dpr \| SCENE= }}~~		==See Also==
			*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	~~===Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril~~===		__TOC__
			</StructureSection>

	~~==About this Structure~~==
	[[~~4dpr~~]] ~~is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki~~/~~Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA].~~
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Haeggstrom, J Z.]]		[[Category: Haeggstrom, J Z]]
	[[Category: Rinaldo-Matthis, A.]]		[[Category: Rinaldo-Matthis, A]]
	[[Category: Stsiapanava, A.]]		[[Category: Stsiapanava, A]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Leukotriene a4]]		[[Category: Leukotriene a4]]

OCA at 13:56, 20 February 2013

2013-02-20T13:56:45Z

← Older revision		Revision as of 13:56, 20 February 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4dpr.jpg\|left\|200px]]

	~~The entry~~ 4dpr ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4dpr\| PDB=4dpr \| SCENE= }}

	~~Authors: Stsiapanava, A., Haeggstrom, J.Z., Rinaldo-Matthis, A.~~		===Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril===

	~~Description~~: ~~Structure of human Leukotriene A4~~ hydrolase in complex ~~with inhibitor captopril~~
			==About this Structure==
			[[4dpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPR OCA].
			[[Category: Homo sapiens]]
			[[Category: Haeggstrom, J Z.]]
			[[Category: Rinaldo-Matthis, A.]]
			[[Category: Stsiapanava, A.]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
			[[Category: Leukotriene a4]]
			[[Category: Metalloprotein]]
			[[Category: Protease]]
			[[Category: Zinc binding]]

OCA at 06:11, 14 March 2012

2012-03-14T06:11:32Z

← Older revision		Revision as of 06:11, 14 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4dpr is ON HOLD		The entry 4dpr is ON HOLD until Paper Publication

	Authors: Stsiapanava, A., Haeggstrom, J.Z., Rinaldo-Matthis, A.		Authors: Stsiapanava, A., Haeggstrom, J.Z., Rinaldo-Matthis, A.

	Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril		Description: Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril

OCA: Protected "4dpr" [edit=sysop:move=sysop]

2012-02-22T07:32:24Z

Protected "4dpr" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:32, 22 February 2012
(No difference)