4dvb - Revision history

OCA at 08:40, 21 September 2022

2022-09-21T08:40:04Z

← Older revision		Revision as of 08:40, 21 September 2022
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	<StructureSection load='4dvb' size='340' side='right'caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='4dvb' size='340' side='right'caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dvb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2brr\|2brr]], [[2r4r\|2r4r]], [[4dw2\|4dw2]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvb OCA], [https://pdbe.org/4dvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dvb RCSB], [https://www.ebi.ac.uk/pdbsum/4dvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvb OCA], [~~http~~://pdbe.org/4dvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen~~, L M~~]]		[[Category: Andersen LM]]
	[[Category: Andreasen~~, P A~~]]		[[Category: Andreasen PA]]
	[[Category: Botkjaer~~, K A~~]]		[[Category: Botkjaer KA]]
	[[Category: Huang, M]]		[[Category: Huang M]]
	[[Category: Jiang, L]]		[[Category: Jiang L]]
	[[Category: Yuan, C]]		[[Category: Yuan C]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Immune system~~]]

OCA at 07:49, 27 March 2019

2019-03-27T07:49:49Z

← Older revision		Revision as of 07:49, 27 March 2019
Line 1:		Line 1:

	==The crystal structure of the Fab fragment of pro-uPA antibody mAb-112==		==The crystal structure of the Fab fragment of pro-uPA antibody mAb-112==
	<StructureSection load='4dvb' size='340' side='right' caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='4dvb' size='340' side='right'caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVB FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen, L M]]		[[Category: Andersen, L M]]

OCA at 02:55, 11 December 2016

2016-12-11T02:55:34Z

← Older revision		Revision as of 02:55, 11 December 2016
Line 1:		Line 1:

	==The crystal structure of the Fab fragment of pro-uPA antibody mAb-112==		==The crystal structure of the Fab fragment of pro-uPA antibody mAb-112==
	<StructureSection load='4dvb' size='340' side='right' caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='4dvb' size='340' side='right' caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2brr\|2brr]], [[2r4r\|2r4r]], [[4dw2\|4dw2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2brr\|2brr]], [[2r4r\|2r4r]], [[4dw2\|4dw2]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dvb RCSB], [http://www.ebi.ac.uk/pdbsum/4dvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvb OCA], [http://pdbe.org/4dvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dvb RCSB], [http://www.ebi.ac.uk/pdbsum/4dvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4dvb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]		*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:06, 9 December 2014

2014-12-09T17:06:41Z

← Older revision		Revision as of 17:06, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4dvb~~.~~jpg~~\|~~left~~\|~~200px~~]]		==The crystal structure of the Fab fragment of pro-uPA antibody mAb-112==
			<StructureSection load='4dvb' size='340' side='right' caption='[[4dvb]], [[Resolution\|resolution]] 1.93Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4dvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2brr\|2brr]], [[2r4r\|2r4r]], [[4dw2\|4dw2]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dvb RCSB], [http://www.ebi.ac.uk/pdbsum/4dvb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			An important regulatory mechanism of serine proteases is the proteolytic conversion of the inactive pro-enzyme, or zymogen, into the active enzyme. This activation process is generally considered an irreversible process. In the present study, we demonstrate that an active enzyme can be converted back into its zymogen form. We determined the crystal structure of uPA (urokinase-type plasminogen activator) in complex with an inhibitory antibody, revealing that the antibody 'rezymogenizes' already activated uPA. The present study demonstrates a new regulatory mechanism of protease activity, which is also an extreme case of protein allostery. Mechanistically, the antibody binds a single surface-exposed loop, named the autolysis loop, thereby preventing the stabilization of uPA in its active conformation. We argue that this autolysis loop is a key structural element for rezymogenation of other proteases, and will be a new target site for pharmacological intervention with serine protease activity.

	~~{{STRUCTURE_4dvb\| PDB=4dvb \| SCENE= }}~~		Rezymogenation of active urokinase induced by an inhibitory antibody.,Jiang L, Botkjaer KA, Andersen LM, Yuan C, Andreasen PA, Huang M Biochem J. 2013 Jan 1;449(1):161-6. doi: 10.1042/BJ20121132. PMID:23016918<ref>PMID:23016918</ref>

	~~===The crystal structure~~ of the ~~Fab fragment~~ of ~~pro-uPA antibody mAb-112===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23016918}}~~		==See Also==
			*[[Monoclonal Antibody\|Monoclonal Antibody]]
	==~~About this Structure~~==		== References ==
	[[~~4dvb~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen, L M.]]		[[Category: Andersen, L M]]
	[[Category: Andreasen, P A.]]		[[Category: Andreasen, P A]]
	[[Category: Botkjaer, K A.]]		[[Category: Botkjaer, K A]]
	[[Category: Huang, M.]]		[[Category: Huang, M]]
	[[Category: Jiang, L.]]		[[Category: Jiang, L]]
	[[Category: Yuan, C.]]		[[Category: Yuan, C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:00, 16 January 2013

2013-01-16T09:00:40Z

← Older revision		Revision as of 09:00, 16 January 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4dvb.jpg\|left\|200px]]

	~~The entry~~ 4dvb ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4dvb\| PDB=4dvb \| SCENE= }}

	~~Authors: Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.~~		===The crystal structure of the Fab fragment of pro-uPA antibody mAb-112===

	~~Description~~: ~~The crystal structure of the Fab fragment of pro~~-~~uPA antibody mAb-112~~		{{ABSTRACT_PUBMED_23016918}}

			==About this Structure==
			[[4dvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVB OCA].
			[[Category: Mus musculus]]
			[[Category: Andersen, L M.]]
			[[Category: Andreasen, P A.]]
			[[Category: Botkjaer, K A.]]
			[[Category: Huang, M.]]
			[[Category: Jiang, L.]]
			[[Category: Yuan, C.]]
			[[Category: Hydrolase]]
			[[Category: Immune system]]

OCA at 06:12, 14 March 2012

2012-03-14T06:12:37Z

← Older revision		Revision as of 06:12, 14 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4dvb is ON HOLD		The entry 4dvb is ON HOLD until Paper Publication

	Authors: Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.		Authors: Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.

	Description: The crystal structure of the Fab fragment of pro-uPA antibody mAb-112		Description: The crystal structure of the Fab fragment of pro-uPA antibody mAb-112

OCA at 05:26, 8 March 2012

2012-03-08T05:26:52Z

← Older revision		Revision as of 05:26, 8 March 2012
Line 3:		Line 3:
	The entry 4dvb is ON HOLD		The entry 4dvb is ON HOLD

	Authors: ~~Longguang~~ Jiang, ~~Kenneth~~ A. ~~Botkjaer~~, ~~Lisbeth~~ M. ~~Andersen~~, ~~Cai~~ Yuan, ~~Peter~~ A. ~~Andreasen~~, ~~Mingdong~~ Huang		Authors: Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.

	Description: The crystal structure of the Fab fragment of pro-uPA antibody mAb-112		Description: The crystal structure of the Fab fragment of pro-uPA antibody mAb-112

OCA: Protected "4dvb" [edit=sysop:move=sysop]

2012-02-29T08:29:35Z

Protected "4dvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:29, 29 February 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4dvb is ON HOLD Authors: Longguang Jiang, Kenneth A. Botkjaer, Lisbeth M. Andersen, Cai Yuan, Peter A. Andreasen, Mingdong Huang Description: The c...

2012-02-29T08:29:35Z

New page: '''Unreleased structure''' The entry 4dvb is ON HOLD Authors: Longguang Jiang, Kenneth A. Botkjaer, Lisbeth M. Andersen, Cai Yuan, Peter A. Andreasen, Mingdong Huang Description: The c...

New page

'''Unreleased structure'''

The entry 4dvb is ON HOLD

Authors: Longguang Jiang, Kenneth A. Botkjaer, Lisbeth M. Andersen, Cai Yuan, Peter A. Andreasen, Mingdong Huang

Description: The crystal structure of the Fab fragment of pro-uPA antibody mAb-112