4dxt - Revision history

OCA at 10:46, 6 November 2024

2024-11-06T10:46:49Z

← Older revision		Revision as of 10:46, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [https://pdbe.org/4dxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [https://www.ebi.ac.uk/pdbsum/4dxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [https://pdbe.org/4dxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [https://www.ebi.ac.uk/pdbsum/4dxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SUN2_HUMAN SUN2_HUMAN]] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.<ref>PMID:18396275</ref>		[https://www.uniprot.org/uniprot/SUN2_HUMAN SUN2_HUMAN] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.<ref>PMID:18396275</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:43, 21 September 2022

2022-09-21T08:43:04Z

← Older revision		Revision as of 08:43, 21 September 2022
Line 1:		Line 1:

	==Human SUN2 (AA 522-717)==		==Human SUN2 (AA 522-717)==
	<StructureSection load='4dxt' size='340' side='right' caption='[[4dxt]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4dxt' size='340' side='right'caption='[[4dxt]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [https://pdbe.org/4dxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [https://www.ebi.ac.uk/pdbsum/4dxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxt ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [~~http~~://pdbe.org/4dxt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dxt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SUN2_HUMAN SUN2_HUMAN]] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.<ref>PMID:18396275</ref>		[[https://www.uniprot.org/uniprot/SUN2_HUMAN SUN2_HUMAN]] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.<ref>PMID:18396275</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Schwartz, T U~~]]		[[Category: Large Structures]]
	[[Category: ~~Sosa, B~~]]		[[Category: Schwartz TU]]
	[[Category: ~~Beta-sandwich]]~~		[[Category: Sosa B]]
	~~[[Category: Linc complex]]~~
	~~[[Category: Structural protein~~]]

OCA at 17:57, 4 August 2016

2016-08-04T17:57:42Z

← Older revision		Revision as of 17:57, 4 August 2016
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	==Human SUN2 (AA 522-717)==		==Human SUN2 (AA 522-717)==
	<StructureSection load='4dxt' size='340' side='right' caption='[[4dxt]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4dxt' size='340' side='right' caption='[[4dxt]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [http://www.ebi.ac.uk/pdbsum/4dxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [http://pdbe.org/4dxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [http://www.ebi.ac.uk/pdbsum/4dxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4dxt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]
	[[Category: Sosa, B]]		[[Category: Sosa, B]]

OCA at 11:39, 25 December 2014

2014-12-25T11:39:35Z

← Older revision		Revision as of 11:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [http://www.ebi.ac.uk/pdbsum/4dxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [http://www.ebi.ac.uk/pdbsum/4dxt PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SUN2_HUMAN SUN2_HUMAN]] Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.<ref>PMID:18396275</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins.,Sosa BA, Rothballer A, Kutay U, Schwartz TU Cell. 2012 May 25;149(5):1035-47. PMID:22632968<ref>PMID:22632968</ref>		LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins.,Sosa BA, Rothballer A, Kutay U, Schwartz TU Cell. 2012 May 25;149(5):1035-47. PMID:22632968<ref>PMID:22632968</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U]]
	[[Category: Sosa, B.]]		[[Category: Sosa, B]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Linc complex]]		[[Category: Linc complex]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 07:13, 5 June 2014

2014-06-05T07:13:18Z

← Older revision		Revision as of 07:13, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4dxt~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Human SUN2 (AA 522-717)==
			<StructureSection load='4dxt' size='340' side='right' caption='[[4dxt]], [[Resolution\|resolution]] 2.22Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4dxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dxr\|4dxr]], [[4dxs\|4dxs]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dxt RCSB], [http://www.ebi.ac.uk/pdbsum/4dxt PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration, and anchorage. We present crystal structures of the human SUN2-KASH1/2 complex, the core of the LINC complex. The SUN2 domain is rigidly attached to a trimeric coiled coil that prepositions it to bind three KASH peptides. The peptides bind in three deep and expansive grooves formed between adjacent SUN domains, effectively acting as molecular glue. In addition, a disulfide between conserved cysteines on SUN and KASH covalently links both proteins. The structure provides the basis of LINC complex formation and suggests a model for how LINC complexes might arrange into higher-order clusters to enhance force-coupling.

	~~<!--~~		LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins.,Sosa BA, Rothballer A, Kutay U, Schwartz TU Cell. 2012 May 25;149(5):1035-47. PMID:22632968<ref>PMID:22632968</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_4dxt"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_4dxt\| PDB=4dxt \| SCENE= }}~~

	~~===Human SUN2 (AA 522-717)===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22632968}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22632968 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22632968}}~~

	~~==About this Structure==~~
	~~[[4dxt]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXT OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022632968<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U.]]

OCA at 07:38, 6 June 2012

2012-06-06T07:38:18Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4dxt.jpg|left|200px]]
-The entry 4dxt is ON HOLD  until Paper Publication
+<!--
-Authors: Sosa, B., Schwartz, T.U.
+===Human SUN2 (AA 522-717)===
-Description:

OCA at 05:44, 4 April 2012

2012-04-04T05:44:05Z

← Older revision		Revision as of 05:44, 4 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4dxt is ON HOLD		The entry 4dxt is ON HOLD until Paper Publication

	Authors: Sosa, B.		Authors: Sosa, B., Schwartz, T.U.

	Description: ~~Protein Complex~~		Description:

OCA: Protected "4dxt" [edit=sysop:move=sysop]

2012-03-08T05:29:04Z

Protected "4dxt" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:29, 8 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4dxt is ON HOLD Authors: Sosa, B. Description: Protein Complex

2012-03-08T05:29:01Z

New page: '''Unreleased structure''' The entry 4dxt is ON HOLD Authors: Sosa, B. Description: Protein Complex

New page

'''Unreleased structure'''

The entry 4dxt is ON HOLD

Authors: Sosa, B.

Description: Protein Complex