4e2o - Revision history

OCA at 13:45, 8 November 2023

2023-11-08T13:45:37Z

← Older revision		Revision as of 13:45, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_CCB_US3_UF5 Geobacillus thermoleovorans CCB_US3_UF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_CCB_US3_UF5 Geobacillus thermoleovorans CCB_US3_UF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E2O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.103Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [https://pdbe.org/4e2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [https://www.ebi.ac.uk/pdbsum/4e2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [https://pdbe.org/4e2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [https://www.ebi.ac.uk/pdbsum/4e2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/G8N704_GEOTH G8N704_GEOTH]]		[https://www.uniprot.org/uniprot/G8N704_GEOTH G8N704_GEOTH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:46, 28 September 2022

2022-09-28T06:46:32Z

← Older revision		Revision as of 06:46, 28 September 2022
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	==Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose==		==Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose==
	<StructureSection load='4e2o' size='340' side='right' caption='[[4e2o]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4e2o' size='340' side='right'caption='[[4e2o]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Geobacillus_thermoleovorans_ccb_us3_uf5~~ Geobacillus thermoleovorans ~~ccb_us3_uf5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_CCB_US3_UF5 Geobacillus thermoleovorans CCB_US3_UF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E2O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [https://pdbe.org/4e2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [https://www.ebi.ac.uk/pdbsum/4e2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2o ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [~~http~~://pdbe.org/4e2o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e2o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2o ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/G8N704_GEOTH G8N704_GEOTH]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4e2o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4e2o" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Amylase 3D structures\|Amylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Alpha-amylase~~]]		[[Category: Geobacillus thermoleovorans CCB_US3_UF5]]
	[[Category: ~~Geobacillus thermoleovorans ccb_us3_uf5~~]]		[[Category: Large Structures]]
	[[Category: Alam, M]]		[[Category: Alam M]]
	[[Category: Mok~~, S C~~]]		[[Category: Mok SC]]
	[[Category: Najimudin, N]]		[[Category: Najimudin N]]
	[[Category: Saito~~, J A~~]]		[[Category: Saito JA]]
	[[Category: Teh~~, A H]]~~		[[Category: Teh AH]]
	~~[[Category: Calcium binding]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Tim barrel~~]]

OCA at 09:44, 25 October 2017

2017-10-25T09:44:12Z

← Older revision		Revision as of 09:44, 25 October 2017
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	</div>		</div>
	<div class="pdbe-citations 4e2o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4e2o" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Amylase\|Amylase]]
	*[[User:Gabriel Pons/Sandbox 2\|User:Gabriel Pons/Sandbox 2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:44, 11 August 2016

2016-08-11T14:44:05Z

← Older revision		Revision as of 14:44, 11 August 2016
Line 1:		Line 1:

	==Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose==		==Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose==
	<StructureSection load='4e2o' size='340' side='right' caption='[[4e2o]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4e2o' size='340' side='right' caption='[[4e2o]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [http://www.ebi.ac.uk/pdbsum/4e2o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [http://pdbe.org/4e2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [http://www.ebi.ac.uk/pdbsum/4e2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4e2o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:58, 5 January 2015

2015-01-05T12:58:52Z

← Older revision		Revision as of 12:58, 5 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_ccb_us3_uf5 Geobacillus thermoleovorans ccb_us3_uf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_ccb_us3_uf5 Geobacillus thermoleovorans ccb_us3_uf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E2O FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [http://www.ebi.ac.uk/pdbsum/4e2o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [http://www.ebi.ac.uk/pdbsum/4e2o PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Amylase\|Amylase]]		*[[Amylase\|Amylase]]
			*[[User:Gabriel Pons/Sandbox 2\|User:Gabriel Pons/Sandbox 2]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Alpha-amylase]]		[[Category: Alpha-amylase]]
	[[Category: Geobacillus thermoleovorans ccb_us3_uf5]]		[[Category: Geobacillus thermoleovorans ccb_us3_uf5]]
	[[Category: Alam, M.]]		[[Category: Alam, M]]
	[[Category: Mok, S C.]]		[[Category: Mok, S C]]
	[[Category: Najimudin, N.]]		[[Category: Najimudin, N]]
	[[Category: Saito, J A.]]		[[Category: Saito, J A]]
	[[Category: Teh, A H.]]		[[Category: Teh, A H]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 06:42, 23 July 2014

2014-07-23T06:42:35Z

← Older revision		Revision as of 06:42, 23 July 2014
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	~~{{STRUCTURE_4e2o~~\| ~~PDB~~=4e2o \| ~~SCENE~~= }}		==Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose==
	===~~Crystal structure~~ of alpha-amylase from Geobacillus thermoleovorans, GTA, ~~complexed~~ with acarbose~~===~~		<StructureSection load='4e2o' size='340' side='right' caption='[[4e2o]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_ccb_us3_uf5 Geobacillus thermoleovorans ccb_us3_uf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E2O FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTCCBUS3UF5_7870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1111068 Geobacillus thermoleovorans CCB_US3_UF5])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e2o RCSB], [http://www.ebi.ac.uk/pdbsum/4e2o PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A truncated form of an alpha-amylase, GTA, from thermophilic Geobacillus thermoleovorans CCB_US3_UF5 was biochemically and structurally characterized. The recombinant GTA, which lacked both the N- and C-terminal transmembrane regions, functioned optimally at 70 degrees C and pH 6.0. While enzyme activity was not enhanced by the addition of CaCl2, GTA's thermostability was significantly improved in the presence of CaCl2. The structure, in complex with an acarbose-derived pseudo-hexasaccharide, consists of the typical three domains and binds one Ca(2+) ion. This Ca(2+) ion was strongly bound and not chelated by EDTA. A predicted second Ca(2+)-binding site, however, was disordered. With limited subsites, two novel substrate-binding residues, Y147 and Y182, may help increase substrate affinity. No distinct starch-binding domain is present, although two regions rich in aromatic residues have been observed. GTA, with a smaller domain B and several shorter loops compared to other alpha-amylases, has one of the most compact alpha-amylase folds that may contribute greatly to its tight Ca(2+) binding and thermostability.

	~~==About this Structure==~~		Crystal structure of a compact alpha-amylase from Geobacillus thermoleovorans.,Mok SC, Teh AH, Saito JA, Najimudin N, Alam M Enzyme Microb Technol. 2013 Jun 10;53(1):46-54. doi:, 10.1016/j.enzmictec.2013.03.009. Epub 2013 Mar 28. PMID:23683704<ref>PMID:23683704</ref>
	~~[[4e2o]] is~~ a 1 ~~chain structure with sequence from [http~~:/~~/en~~.~~wikipedia~~.~~org/wiki/Geobacillus_thermoleovorans_ccb_us3_uf5 Geobacillus thermoleovorans ccb_us3_uf5]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4E2O OCA~~].
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
			*[[Amylase\|Amylase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Alpha-amylase]]		[[Category: Alpha-amylase]]
	[[Category: Geobacillus thermoleovorans ccb_us3_uf5]]		[[Category: Geobacillus thermoleovorans ccb_us3_uf5]]
			[[Category: Alam, M.]]
	[[Category: Mok, S C.]]		[[Category: Mok, S C.]]
			[[Category: Najimudin, N.]]
			[[Category: Saito, J A.]]
	[[Category: Teh, A H.]]		[[Category: Teh, A H.]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 10:28, 13 March 2013

2013-03-13T10:28:10Z

← Older revision		Revision as of 10:28, 13 March 2013
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	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4e2o\| PDB=4e2o \| SCENE= }}
			===Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA, complexed with acarbose===

	~~The entry~~ 4e2o is ~~ON HOLD until Paper Publication~~		==About this Structure==
			[[4e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermoleovorans_ccb_us3_uf5 Geobacillus thermoleovorans ccb_us3_uf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2O OCA].
	~~Authors~~: ~~Teh, A~~.H.~~, Mok, S~~.C.		[[Category: Alpha-amylase]]
			[[Category: Geobacillus thermoleovorans ccb_us3_uf5]]
	~~Description~~: ~~Crystal structure of alpha~~-amylase ~~from~~ Geobacillus thermoleovorans, ~~GTA2~~, ~~complexed with acarbose~~		[[Category: Mok, S C.]]
			[[Category: Teh, A H.]]
			[[Category: Calcium binding]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
			[[Category: Tim barrel]]

OCA at 05:14, 15 August 2012

2012-08-15T05:14:36Z

← Older revision		Revision as of 05:14, 15 August 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e2o is ON HOLD		The entry 4e2o is ON HOLD until Paper Publication

	Authors: Teh, A.H., Mok, S.C.		Authors: Teh, A.H., Mok, S.C.

	Description: Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA2, complexed with acarbose		Description: Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA2, complexed with acarbose

OCA: Protected "4e2o" [edit=sysop:move=sysop]

2012-03-14T06:17:21Z

Protected "4e2o" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:17, 14 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4e2o is ON HOLD Authors: Teh, A.H., Mok, S.C. Description: Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA2, complexed wit...

2012-03-14T06:17:20Z

New page: '''Unreleased structure''' The entry 4e2o is ON HOLD Authors: Teh, A.H., Mok, S.C. Description: Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA2, complexed wit...

New page

'''Unreleased structure'''

The entry 4e2o is ON HOLD

Authors: Teh, A.H., Mok, S.C.

Description: Crystal structure of alpha-amylase from Geobacillus thermoleovorans, GTA2, complexed with acarbose