4e3c - Revision history

OCA at 14:51, 14 March 2024

2024-03-14T14:51:16Z

← Older revision		Revision as of 14:51, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E3C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E3C FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [https://pdbe.org/4e3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [https://www.ebi.ac.uk/pdbsum/4e3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3c ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.98Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [https://pdbe.org/4e3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [https://www.ebi.ac.uk/pdbsum/4e3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>		[https://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:47, 28 September 2022

2022-09-28T06:47:22Z

← Older revision		Revision as of 06:47, 28 September 2022
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	==X-ray crystal structure of human IKK2 in an active conformation==		==X-ray crystal structure of human IKK2 in an active conformation==
	<StructureSection load='4e3c' size='340' side='right' caption='[[4e3c]], [[Resolution\|resolution]] 3.98Å' scene=''>		<StructureSection load='4e3c' size='340' side='right'caption='[[4e3c]], [[Resolution\|resolution]] 3.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E3C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E3C FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [https://pdbe.org/4e3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [https://www.ebi.ac.uk/pdbsum/4e3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3c ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [~~http~~://pdbe.org/4e3c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e3c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>		[[https://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~I-kappa-B kinase~~]]		[[Category: Large Structures]]
	[[Category: Ghosh, G]]		[[Category: Ghosh G]]
	[[Category: Hauenstein~~, A V~~]]		[[Category: Hauenstein AV]]
	[[Category: Huang~~, D B~~]]		[[Category: Huang DB]]
	[[Category: Huxford, T]]		[[Category: Huxford T]]
	[[Category: Polley, S]]		[[Category: Polley S]]
	~~[[Category: Auto-phosphorylation]]~~
	~~[[Category: Kanase]]~~
	~~[[Category: Nemo binding]]~~
	~~[[Category: Transferase~~]]

OCA at 19:10, 4 August 2016

2016-08-04T19:10:22Z

← Older revision		Revision as of 19:10, 4 August 2016
Line 1:		Line 1:

	==X-ray crystal structure of human IKK2 in an active conformation==		==X-ray crystal structure of human IKK2 in an active conformation==
	<StructureSection load='4e3c' size='340' side='right' caption='[[4e3c]], [[Resolution\|resolution]] 3.98Å' scene=''>		<StructureSection load='4e3c' size='340' side='right' caption='[[4e3c]], [[Resolution\|resolution]] 3.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E3C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E3C FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://pdbe.org/4e3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: I-kappa-B kinase]]		[[Category: I-kappa-B kinase]]
	[[Category: Ghosh, G]]		[[Category: Ghosh, G]]

OCA at 18:34, 24 December 2014

2014-12-24T18:34:23Z

← Older revision		Revision as of 18:34, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:50, 21 December 2014

2014-12-21T10:50:38Z

← Older revision		Revision as of 10:50, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4e3c\| PDB=4e3c \| SCENE= }}~~		==X-ray crystal structure of human IKK2 in an active conformation==
	===X-ray crystal structure of human IKK2 in an active conformation===		<StructureSection load='4e3c' size='340' side='right' caption='[[4e3c]], [[Resolution\|resolution]] 3.98Å' scene=''>
			== Structural highlights ==
	==~~Function~~==		<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E3C FirstGlance]. <br>
	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~IKKB_HUMAN IKKB_HUMAN~~]~~] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which~~ is ~~activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses~~. ~~Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues~~. ~~These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome~~. ~~In turn, free NF~~-~~kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis~~. ~~In addition to~~ the ~~NF-kappa-B inhibitors, phosphorylates several other~~ components ~~of the signaling pathway including NEMO~~/~~IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE~~. ~~IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs~~. ~~Also phosphorylates other substrates including NCOA3, BCL10 and IRS1~~. ~~Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV~~-~~induced NF-kappa-B activation~~.<~~ref~~>~~PMID:11297557~~</~~ref~~> <~~ref~~>~~PMID~~:~~17213322~~</~~ref~~> <~~ref~~>~~PMID~~:~~20434986~~</~~ref~~> <~~ref~~>~~PMID~~:~~20410276~~</~~ref~~> <~~ref~~>~~PMID~~:~~20797629~~</~~ref~~> <~~ref~~>~~PMID:21138416~~</~~ref~~>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
	==~~About this Structure~~==		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum]</span></td></tr>
	~~[[4e3c]] is a 6 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4E3C~~ OCA].		</table>
			__TOC__
	~~==Reference=~~=		</StructureSection>
	<~~references group="xtra"~~/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: I-kappa-B kinase]]		[[Category: I-kappa-B kinase]]
	[[Category: Ghosh, G.]]		[[Category: Ghosh, G]]
	[[Category: Hauenstein, A V.]]		[[Category: Hauenstein, A V]]
	[[Category: Huang, D B.]]		[[Category: Huang, D B]]
	[[Category: Huxford, T.]]		[[Category: Huxford, T]]
	[[Category: Polley, S.]]		[[Category: Polley, S]]
	[[Category: Auto-phosphorylation]]		[[Category: Auto-phosphorylation]]
	[[Category: Kanase]]		[[Category: Kanase]]
	[[Category: Nemo binding]]		[[Category: Nemo binding]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:20, 20 June 2013

2013-06-20T07:20:28Z

← Older revision		Revision as of 07:20, 20 June 2013
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4e3c\| PDB=4e3c \| SCENE= }}
			===X-ray crystal structure of human IKK2 in an active conformation===

	~~The entry 4e3c~~ is ~~ON HOLD~~ ~~until May 17 2014~~		==Function==
			[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>

	~~Authors~~: ~~Polley, S~~.~~, Huang, D~~.B.~~, Hauenstein, A~~.V.~~, Ghosh, G~~.~~, Huxford, T~~.		==About this Structure==
			[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA].

	~~Description~~: X-~~ray crystal structure of human IKK2 in an active conformation~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Homo sapiens]]
			[[Category: I-kappa-B kinase]]
			[[Category: Ghosh, G.]]
			[[Category: Hauenstein, A V.]]
			[[Category: Huang, D B.]]
			[[Category: Huxford, T.]]
			[[Category: Polley, S.]]
			[[Category: Auto-phosphorylation]]
			[[Category: Kanase]]
			[[Category: Nemo binding]]
			[[Category: Transferase]]

OCA at 06:42, 16 May 2013

2013-05-16T06:42:53Z

← Older revision		Revision as of 06:42, 16 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e3c is ON HOLD until May 09 2014		The entry 4e3c is ON HOLD until May 17 2014

	Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.		Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.

	Description: X-ray crystal structure of human IKK2 in an active conformation		Description: X-ray crystal structure of human IKK2 in an active conformation

OCA at 19:43, 17 April 2013

2013-04-17T19:43:46Z

← Older revision		Revision as of 19:43, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e3c is ON HOLD until ~~Apr~~ 09 2014		The entry 4e3c is ON HOLD until May 09 2014

	Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.		Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.

	Description: X-ray crystal structure of human IKK2 in an active conformation		Description: X-ray crystal structure of human IKK2 in an active conformation

OCA at 09:43, 13 March 2013

2013-03-13T09:43:58Z

← Older revision		Revision as of 09:43, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e3c is ON HOLD until ~~Mar~~ 09 2014		The entry 4e3c is ON HOLD until Apr 09 2014

	Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.		Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.

	Description: X-ray crystal structure of human IKK2 in an active conformation		Description: X-ray crystal structure of human IKK2 in an active conformation

OCA at 05:35, 23 May 2012

2012-05-23T05:35:26Z

← Older revision		Revision as of 05:35, 23 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e3c is ON HOLD		The entry 4e3c is ON HOLD until Mar 09 2014

	Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.		Authors: Polley, S., Huang, D.B., Hauenstein, A.V., Ghosh, G., Huxford, T.

	Description: X-ray crystal structure of human IKK2 in an active conformation		Description: X-ray crystal structure of human IKK2 in an active conformation