4e40 - Revision history

OCA at 08:19, 9 October 2024

2024-10-09T08:19:03Z

← Older revision		Revision as of 08:19, 9 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_congolense_IL3000 Trypanosoma congolense IL3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E40 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_congolense_IL3000 Trypanosoma congolense IL3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E40 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [https://pdbe.org/4e40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [https://www.ebi.ac.uk/pdbsum/4e40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e40 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [https://pdbe.org/4e40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [https://www.ebi.ac.uk/pdbsum/4e40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e40 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/G0UVW6_TRYCI G0UVW6_TRYCI]]		[https://www.uniprot.org/uniprot/G0UVW6_TRYCI G0UVW6_TRYCI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:48, 28 September 2022

2022-09-28T06:48:39Z

← Older revision		Revision as of 06:48, 28 September 2022
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	==The haptoglobin-hemoglobin receptor of Trypanosoma congolense==		==The haptoglobin-hemoglobin receptor of Trypanosoma congolense==
	<StructureSection load='4e40' size='340' side='right' caption='[[4e40]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4e40' size='340' side='right'caption='[[4e40]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Tryci Tryci~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E40 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_congolense_IL3000 Trypanosoma congolense IL3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E40 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCIL3000_10_2930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 TRYCI])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [https://pdbe.org/4e40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [https://www.ebi.ac.uk/pdbsum/4e40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e40 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [~~http~~://pdbe.org/4e40 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e40 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e40 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/G0UVW6_TRYCI G0UVW6_TRYCI]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Tryci~~]]		[[Category: Large Structures]]
	[[Category: Brown, A]]		[[Category: Trypanosoma congolense IL3000]]
	[[Category: Carrington, M]]		[[Category: Brown A]]
	[[Category: Higgins~~, M K~~]]		[[Category: Carrington M]]
	[[Category: Reed, J]]		[[Category: Higgins MK]]
	[[Category: Tkachenko, O]]		[[Category: Reed J]]
	~~[[Category: Cell surface]]~~		[[Category: Tkachenko O]]
	~~[[Category: Haptoglobin-hemoglobin receptor]]~~
	~~[[Category: Helical bundle]]~~
	~~[[Category: Receptor]]~~
	~~[[Category: Transport protein~~]]

OCA at 02:56, 11 December 2016

2016-12-11T02:56:13Z

← Older revision		Revision as of 02:56, 11 December 2016
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	==The haptoglobin-hemoglobin receptor of Trypanosoma congolense==		==The haptoglobin-hemoglobin receptor of Trypanosoma congolense==
	<StructureSection load='4e40' size='340' side='right' caption='[[4e40]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4e40' size='340' side='right' caption='[[4e40]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_congolense_il3000 Trypanosoma congolense il3000~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E40 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryci Tryci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E40 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCIL3000_10_2930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 ~~Trypanosoma congolense IL3000~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCIL3000_10_2930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 TRYCI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [http://www.ebi.ac.uk/pdbsum/4e40 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [http://pdbe.org/4e40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [http://www.ebi.ac.uk/pdbsum/4e40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e40 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4e40" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Trypanosoma congolense il3000~~]]		[[Category: Tryci]]
	[[Category: Brown, A]]		[[Category: Brown, A]]
	[[Category: Carrington, M]]		[[Category: Carrington, M]]

OCA at 16:22, 9 December 2014

2014-12-09T16:22:35Z

← Older revision		Revision as of 16:22, 9 December 2014
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	[[~~Image~~:4e40.~~png\|left\|200px~~]]		==The haptoglobin-hemoglobin receptor of Trypanosoma congolense==
			<StructureSection load='4e40' size='340' side='right' caption='[[4e40]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4e40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_congolense_il3000 Trypanosoma congolense il3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E40 FirstGlance]. <br>
			</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCIL3000_10_2930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 Trypanosoma congolense IL3000])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e40 RCSB], [http://www.ebi.ac.uk/pdbsum/4e40 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin-hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 from serum, contributing to innate immunity. Here, the crystal structure of HpHbR from Trypanosoma congolense has been solved, revealing an elongated three alpha-helical bundle with a small membrane distal head. To understand the receptor in the context of the VSG layer, the dimensions of Trypanosoma brucei HpHbR and VSG have been determined by small-angle X-ray scattering, revealing the receptor to be more elongated than VSG. It is, therefore, likely that the receptor protrudes above the VSG layer and unlikely that the VSG coat can prevent immunoglobulin binding to the receptor. The HpHb-binding site has been mapped by single-residue mutagenesis and surface plasmon resonance. This site is located where it is readily accessible above the VSG layer. A single HbHpR polymorphism unique to human infective T. brucei gambiense has been shown to be sufficient to reduce binding of both HpHb and TLF1, modulating ligand affinity in a delicate balancing act that allows nutrient acquisition but avoids TLF1 uptake.

	~~{{STRUCTURE_4e40\| PDB=4e40 \| SCENE= }}~~		Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.,Higgins MK, Tkachenko O, Brown A, Reed J, Raper J, Carrington M Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1905-10. doi:, 10.1073/pnas.1214943110. Epub 2013 Jan 14. PMID:23319650<ref>PMID:23319650</ref>

	~~===The haptoglobin-hemoglobin receptor~~ of ~~Trypanosoma congolense===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_23319650}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[4e40]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Trypanosoma_congolense_il3000 Trypanosoma congolense il3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA].~~		</StructureSection>
	[[Category: Trypanosoma congolense il3000]]		[[Category: Trypanosoma congolense il3000]]
	[[Category: Brown, A.]]		[[Category: Brown, A]]
	[[Category: Carrington, M.]]		[[Category: Carrington, M]]
	[[Category: Higgins, M K.]]		[[Category: Higgins, M K]]
	[[Category: Reed, J.]]		[[Category: Reed, J]]
	[[Category: Tkachenko, O.]]		[[Category: Tkachenko, O]]
	[[Category: Cell surface]]		[[Category: Cell surface]]
	[[Category: Haptoglobin-hemoglobin receptor]]		[[Category: Haptoglobin-hemoglobin receptor]]

OCA at 09:47, 13 February 2013

2013-02-13T09:47:15Z

← Older revision		Revision as of 09:47, 13 February 2013
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	[[Image:4e40.~~jpg~~\|left\|200px]]		[[Image:4e40.png\|left\|200px]]

	{{STRUCTURE_4e40\| PDB=4e40 \| SCENE= }}		{{STRUCTURE_4e40\| PDB=4e40 \| SCENE= }}
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	===The haptoglobin-hemoglobin receptor of Trypanosoma congolense===		===The haptoglobin-hemoglobin receptor of Trypanosoma congolense===

			{{ABSTRACT_PUBMED_23319650}}

	==About this Structure==		==About this Structure==

OCA at 09:10, 16 January 2013

2013-01-16T09:10:05Z

← Older revision		Revision as of 09:10, 16 January 2013
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	~~'''Unreleased structure'''~~		[[Image:4e40.jpg\|left\|200px]]

	~~The entry~~ 4e40 ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4e40\| PDB=4e40 \| SCENE= }}

	~~Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M.~~		===The haptoglobin-hemoglobin receptor of Trypanosoma congolense===

	~~Description~~: ~~The haptoglobin~~-hemoglobin receptor ~~of Trypanosoma congolense~~
			==About this Structure==
			[[4e40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_congolense_il3000 Trypanosoma congolense il3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E40 OCA].
			[[Category: Trypanosoma congolense il3000]]
			[[Category: Brown, A.]]
			[[Category: Carrington, M.]]
			[[Category: Higgins, M K.]]
			[[Category: Reed, J.]]
			[[Category: Tkachenko, O.]]
			[[Category: Cell surface]]
			[[Category: Haptoglobin-hemoglobin receptor]]
			[[Category: Helical bundle]]
			[[Category: Receptor]]
			[[Category: Transport protein]]

OCA at 06:38, 11 April 2012

2012-04-11T06:38:42Z

← Older revision		Revision as of 06:38, 11 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4e40 is ON HOLD		The entry 4e40 is ON HOLD until Paper Publication

	Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M.		Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M.

	Description: The haptoglobin-hemoglobin receptor of Trypanosoma congolense		Description: The haptoglobin-hemoglobin receptor of Trypanosoma congolense

OCA: Protected "4e40" [edit=sysop:move=sysop]

2012-03-21T07:16:22Z

Protected "4e40" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:16, 21 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4e40 is ON HOLD Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M. Description: The haptoglobin-hemoglobin receptor of Tryp...

2012-03-21T07:16:21Z

New page: '''Unreleased structure''' The entry 4e40 is ON HOLD Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M. Description: The haptoglobin-hemoglobin receptor of Tryp...

New page

'''Unreleased structure'''

The entry 4e40 is ON HOLD

Authors: Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M.

Description: The haptoglobin-hemoglobin receptor of Trypanosoma congolense