4e61 - Revision history

OCA at 11:02, 1 March 2024

2024-03-01T11:02:07Z

← Older revision		Revision as of 11:02, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [https://pdbe.org/4e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [https://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [https://pdbe.org/4e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [https://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST]] Binds microtubules.		[https://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST] Binds microtubules.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Mitosis begins with the tethering of chromosomes to the mitotic spindle and their orientation perpendicular to the axis of cell division. In budding yeast, mitotic spindle orientation and the subsequent chromosome segregation are two independent processes. Early spindle orientation is driven by the actin-bound myosin Myo2p, which interacts with the adapter Kar9p. The latter also binds to microtubule-associated Bim1p, thereby connecting both types of cytoskeleton. This study focuses on the interaction between Kar9p and Bim1p and its regulation. We solved the crystal structure of the previously reported Kar9p-binding motif of Bim1p and identified a second, novel Kar9p-interaction domain. We further show that two independent posttranslational modification events regulate their interaction. Whereas Kar9p sumoylation is required for efficient complex formation with Bim1p, Aurora B/Ipl1p-dependent phosphorylation of Bim1p down-regulates their interaction. The observed effects of these modifications allow us to propose a novel regulatory framework for the assembly and disassembly of the early spindle-orientation complex.

	~~Posttranslational modifications regulate assembly of the early spindle-orientation complex in yeast.,Huls D, Storchova Z, Niessing D J Biol Chem. 2012 Mar 29. PMID:22461628<ref>PMID:22461628</ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4e61" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:52, 28 September 2022

2022-09-28T06:52:52Z

← Older revision		Revision as of 06:52, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the EB1-like motif of Bim1p==		==Crystal structure of the EB1-like motif of Bim1p==
	<StructureSection load='4e61' size='340' side='right' caption='[[4e61]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4e61' size='340' side='right'caption='[[4e61]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIM1, YER016W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [https://pdbe.org/4e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [https://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [~~http~~://pdbe.org/4e61 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST]] Binds microtubules.		[[https://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST]] Binds microtubules.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 18824~~]]		[[Category: Large Structures]]
	[[Category: ~~Huels, D~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: ~~Niessing,~~ D]]		[[Category: Huels D]]
	[[Category: ~~Storchova, Z~~]]		[[Category: Niessing D]]
	[[Category: ~~Cell cycle]]~~		[[Category: Storchova Z]]
	~~[[Category: Coiled-coil]]~~
	~~[[Category: Eb1-like motif]]~~
	~~[[Category: Kar9p]]~~
	~~[[Category: Microtubule]]~~
	~~[[Category: Mitosis]]~~
	~~[[Category: Mitotic spindle]]~~
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Spindle orientation~~]]

OCA at 12:40, 4 August 2016

2016-08-04T12:40:23Z

← Older revision		Revision as of 12:40, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the EB1-like motif of Bim1p==		==Crystal structure of the EB1-like motif of Bim1p==
	<StructureSection load='4e61' size='340' side='right' caption='[[4e61]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4e61' size='340' side='right' caption='[[4e61]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIM1, YER016W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIM1, YER016W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [http://www.ebi.ac.uk/pdbsum/4e61 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [http://pdbe.org/4e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [http://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4e61" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Huels, D]]		[[Category: Huels, D]]
	[[Category: Niessing, D]]		[[Category: Niessing, D]]

OCA at 09:23, 25 December 2014

2014-12-25T09:23:47Z

← Older revision		Revision as of 09:23, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIM1, YER016W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIM1, YER016W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [http://www.ebi.ac.uk/pdbsum/4e61 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [http://www.ebi.ac.uk/pdbsum/4e61 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST]] Binds microtubules.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Huels, D.]]		[[Category: Huels, D]]
	[[Category: Niessing, D.]]		[[Category: Niessing, D]]
	[[Category: Storchova, Z.]]		[[Category: Storchova, Z]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]

OCA at 07:50, 5 June 2014

2014-06-05T07:50:54Z

@@ Line 1: / Line 1: @@
-[[Image:4e61.png|left|200px]]
+==Crystal structure of the EB1-like motif of Bim1p==
-<!--
+Posttranslational modifications regulate assembly of the early spindle-orientation complex in yeast.,Huls D, Storchova Z, Niessing D J Biol Chem. 2012 Mar 29. PMID:22461628<ref>PMID:22461628</ref>
-===Crystal structure of the EB1-like motif of Bim1p===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22461628}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22461628 is the PubMed ID number.
+</StructureSection>
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Huels, D.]]

OCA at 05:04, 13 June 2012

2012-06-13T05:04:09Z

← Older revision		Revision as of 05:04, 13 June 2012
Line 1:		Line 1:
	[[Image:4e61.~~jpg~~\|left\|200px]]		[[Image:4e61.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:
	==About this Structure==		==About this Structure==
	[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA].		[[4e61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA].

			==See Also==
			*[[Major Histocompatibility Complex Class I\|Major Histocompatibility Complex Class I]]

	==Reference==		==Reference==

OCA at 06:56, 11 April 2012

2012-04-11T06:56:56Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4e61.jpg|left|200px]]
-The entry 4e61 is ON HOLD
+<!--
-Authors: Huels, D., Storchova, Z., Niessing, D.
+===Crystal structure of the EB1-like motif of Bim1p===
-Description: Crystal structure of the EB1-like motif of Bim1p

OCA: Protected "4e61" [edit=sysop:move=sysop]

2012-03-21T07:18:31Z

Protected "4e61" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:18, 21 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4e61 is ON HOLD Authors: Huels, D., Storchova, Z., Niessing, D. Description: Crystal structure of the EB1-like motif of Bim1p

2012-03-21T07:18:30Z

New page: '''Unreleased structure''' The entry 4e61 is ON HOLD Authors: Huels, D., Storchova, Z., Niessing, D. Description: Crystal structure of the EB1-like motif of Bim1p

New page

'''Unreleased structure'''

The entry 4e61 is ON HOLD

Authors: Huels, D., Storchova, Z., Niessing, D.

Description: Crystal structure of the EB1-like motif of Bim1p