4e71 - Revision history

OCA at 14:54, 14 March 2024

2024-03-14T14:54:01Z

← Older revision		Revision as of 14:54, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E71 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E71 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [https://pdbe.org/4e71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [https://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [https://pdbe.org/4e71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [https://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).		[https://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

	==See Also==		==See Also==
	*[[Plexin\|Plexin]]		*[[Plexin 3D structures\|Plexin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:54, 28 September 2022

2022-09-28T06:54:35Z

← Older revision		Revision as of 06:54, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the RHO GTPASE binding domain of Plexin B2==		==Crystal structure of the RHO GTPASE binding domain of Plexin B2==
	<StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4e71' size='340' side='right'caption='[[4e71]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E71 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E71 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [https://pdbe.org/4e71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [https://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [~~http~~://pdbe.org/4e71 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).		[[https://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

			==See Also==
			*[[Plexin\|Plexin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Large Structures]]
	[[Category: Bountra, C]]		[[Category: Arrowsmith CH]]
	[[Category: Edwards~~, A M~~]]		[[Category: Bountra C]]
	[[Category: Guan, X]]		[[Category: Edwards AM]]
	[[Category: Park, H]]		[[Category: Guan X]]
	~~[[Category: Structural genomic~~]]		[[Category: Park H]]
	[[Category: Tempel, W]]		[[Category: Tempel W]]
	[[Category: Tong, Y]]		[[Category: Tong Y]]
	[[Category: Wang, H]]		[[Category: Wang H]]
	[[Category: Weigelt, J]]		[[Category: Weigelt J]]
	~~[[Category: Plexin]]~~
	~~[[Category: Rbd]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Signaling]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Transmembrane~~]]

OCA at 08:00, 15 November 2017

2017-11-15T08:00:14Z

← Older revision		Revision as of 08:00, 15 November 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).		[[http://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

	~~==See Also==~~
	*[[Plexin\|Plexin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:38, 11 December 2016

2016-12-11T02:38:48Z

← Older revision		Revision as of 02:38, 11 December 2016
Line 1:		Line 1:

	==Crystal structure of the RHO GTPASE binding domain of Plexin B2==		==Crystal structure of the RHO GTPASE binding domain of Plexin B2==
	<StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E71 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E71 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [http://www.ebi.ac.uk/pdbsum/4e71 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [http://pdbe.org/4e71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [http://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).

	==See Also==		==See Also==
Line 12:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 15:35, 9 December 2014

2014-12-09T15:35:13Z

← Older revision		Revision as of 15:35, 9 December 2014
Line 1:		Line 1:
	~~[[Image:4e71.png\|left\|200px]]~~		==Crystal structure of the RHO GTPASE binding domain of Plexin B2==
			<StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution\|resolution]] 2.26Å' scene=''>
	~~{{STRUCTURE_4e71\| PDB=4e71 \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E71 FirstGlance]. <br>
	===Crystal structure of the RHO GTPASE binding domain of Plexin B2===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [http://www.ebi.ac.uk/pdbsum/4e71 PDBsum]</span></td></tr>
	==~~About this Structure~~==		</table>
	[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].

	==See Also==		==See Also==
	*[[Plexin\|Plexin]]		*[[Plexin\|Plexin]]
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Guan, X.]]		[[Category: Guan, X]]
	[[Category: Park, H.]]		[[Category: Park, H]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Tempel, W.]]		[[Category: Tempel, W]]
	[[Category: Tong, Y.]]		[[Category: Tong, Y]]
	[[Category: Wang, H.]]		[[Category: Wang, H]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Plexin]]		[[Category: Plexin]]
	[[Category: Rbd]]		[[Category: Rbd]]
Line 27:		Line 28:
	[[Category: Signaling]]		[[Category: Signaling]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 10:49, 20 October 2012

2012-10-20T10:49:49Z

← Older revision		Revision as of 10:49, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[4e71]] is a 1 chain structure ~~of [[Plexin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].		[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].

	==See Also==		==See Also==

OCA at 03:23, 26 July 2012

2012-07-26T03:23:39Z

← Older revision		Revision as of 03:23, 26 July 2012
Line 1:		Line 1:
	[[Image:4e71.~~jpg~~\|left\|200px]]		[[Image:4e71.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_4e71", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_4e71\| PDB=4e71 \| SCENE= }}		{{STRUCTURE_4e71\| PDB=4e71 \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
	[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].		[[4e71]] is a 1 chain structure of [[Plexin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA].

			==See Also==
			*[[Plexin\|Plexin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "4e71" [edit=sysop:move=sysop]

2012-03-28T07:55:56Z

Protected "4e71" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:55, 28 March 2012
(No difference)