4ea2 - Revision history

OCA at 11:02, 1 March 2024

2024-03-01T11:02:46Z

← Older revision		Revision as of 11:02, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [https://pdbe.org/4ea2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ea2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [https://pdbe.org/4ea2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ea2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]]		[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	We report X-ray crystallographic structures of three inhibitors bound to dehydrosqualene synthase from Staphylococcus aureus: 1 (BPH-651), 2 (WC-9), and 3 (SQ-109). Compound 2 binds to the S2 site with its -SCN group surrounded by four hydrogen bond donors. With 1, we report two structures: in both, the quinuclidine headgroup binds in the allylic (S1) site with the side chain in S2, but in the presence of PPi and Mg(2+), the quinuclidine's cationic center interacts with PPi and three Mg(2+), mimicking a transition state involved in diphosphate ionization. With 3, there are again two structures. In one, the geranyl side chain binds to either S1 or S2 and the adamantane headgroup binds to S1. In the second, the side chain binds to S2 while the headgroup binds to S1. These results provide structural clues for the mechanism and inhibition of the head-to-head prenyl transferases and should aid future drug design.

	Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets.,Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E J Med Chem. 2012 May 10;55(9):4367-72. Epub 2012 May 1. PMID:22486710<ref>PMID:22486710</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ea2" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Squalene synthase\|Squalene synthase]]		*[[Squalene synthase\|Squalene synthase]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:59, 28 September 2022

2022-09-28T06:59:32Z

← Older revision		Revision as of 06:59, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109==		==Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109==
	<StructureSection load='4ea2' size='340' side='right' caption='[[4ea2]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4ea2' size='340' side='right'caption='[[4ea2]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e9z\|4e9z]], [[4ea0\|4ea0]], [[4ea1\|4ea1]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [https://pdbe.org/4ea2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ea2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea2 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4,4'-diapophytoene_synthase 4,4'-diapophytoene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.96 2.5.1.96] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [~~http~~://pdbe.org/4ea2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ea2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ea2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ea2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~4,4'-diapophytoene synthase~~]]		[[Category: Large Structures]]
	[[Category: Li, K]]		[[Category: Staphylococcus aureus]]
	[[Category: Lin, F Y]]		[[Category: Li K]]
	[[Category: Liu, Y L]]		[[Category: Lin F-Y]]
	[[Category: Oldfield, E]]		[[Category: Liu Y-L]]
	~~[[Category: Prenyl transferase]]~~		[[Category: Oldfield E]]
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 09:16, 5 August 2016

2016-08-05T09:16:33Z

← Older revision		Revision as of 09:16, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109==		==Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109==
	<StructureSection load='4ea2' size='340' side='right' caption='[[4ea2]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4ea2' size='340' side='right' caption='[[4ea2]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e9z\|4e9z]], [[4ea0\|4ea0]], [[4ea1\|4ea1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e9z\|4e9z]], [[4ea0\|4ea0]], [[4ea1\|4ea1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4,4'-diapophytoene_synthase 4,4'-diapophytoene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.96 2.5.1.96] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4,4'-diapophytoene_synthase 4,4'-diapophytoene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.96 2.5.1.96] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ea2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [http://pdbe.org/4ea2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ea2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ea2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ea2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: 4,4'-diapophytoene synthase]]		[[Category: 4,4'-diapophytoene synthase]]
	~~[[Category: Staphylococcus aureus]]~~
	[[Category: Li, K]]		[[Category: Li, K]]
	[[Category: Lin, F Y]]		[[Category: Lin, F Y]]

OCA at 17:35, 25 December 2014

2014-12-25T17:35:23Z

← Older revision		Revision as of 17:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EA2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e9z\|4e9z]], [[4ea0\|4ea0]], [[4ea1\|4ea1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e9z\|4e9z]], [[4ea0\|4ea0]], [[4ea1\|4ea1]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4,4'-diapophytoene_synthase 4,4'-diapophytoene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.96 2.5.1.96] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4,4'-diapophytoene_synthase 4,4'-diapophytoene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.96 2.5.1.96] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ea2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ea2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ea2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ea2 PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets.,Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E J Med Chem. 2012 May 10;55(9):4367-72. Epub 2012 May 1. PMID:22486710<ref>PMID:22486710</ref>		Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets.,Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E J Med Chem. 2012 May 10;55(9):4367-72. Epub 2012 May 1. PMID:22486710<ref>PMID:22486710</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 23:		Line 23:
	[[Category: 4,4'-diapophytoene synthase]]		[[Category: 4,4'-diapophytoene synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Li, K.]]		[[Category: Li, K]]
	[[Category: Lin, F Y.]]		[[Category: Lin, F Y]]
	[[Category: Liu, Y L.]]		[[Category: Liu, Y L]]
	[[Category: Oldfield, E.]]		[[Category: Oldfield, E]]
	[[Category: Prenyl transferase]]		[[Category: Prenyl transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:16, 5 June 2014

2014-06-05T07:16:11Z

@@ Line 1: / Line 1: @@
-[[Image:4ea2.png|left|200px]]
+==Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109==
-<!--
+Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets.,Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E J Med Chem. 2012 May 10;55(9):4367-72. Epub 2012 May 1. PMID:22486710<ref>PMID:22486710</ref>
-===Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22486710}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22486710 is the PubMed ID number.
+</StructureSection>
 [[Category: 4,4'-diapophytoene synthase]]
 [[Category: Staphylococcus aureus]]

OCA at 08:23, 16 May 2012

2012-05-16T08:23:37Z

← Older revision		Revision as of 08:23, 16 May 2012
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	[[Image:4ea2.~~jpg~~\|left\|200px]]		[[Image:4ea2.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109===		===Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22486710}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22486710 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22486710}}

	==About this Structure==		==About this Structure==
	[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA].		[[4ea2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EA2 OCA].

			==Reference==
			<ref group="xtra">PMID:022486710</ref><references group="xtra"/>
	[[Category: 4,4'-diapophytoene synthase]]		[[Category: 4,4'-diapophytoene synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA at 09:28, 25 April 2012

2012-04-25T09:28:49Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ea2.jpg|left|200px]]
-The entry 4ea2 is ON HOLD
+<!--
-Authors: Lin, F.-Y., Li, K., Liu, Y.-L., Oldfield, E.
+===Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109===
-Description: Crystal structure of dehydrosqualene synthase complexed with sq-109

OCA: Protected "4ea2" [edit=sysop:move=sysop]

2012-03-28T07:26:14Z

Protected "4ea2" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:26, 28 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ea2 is ON HOLD Authors: Lin, F.-Y., Li, K., Liu, Y.-L., Oldfield, E. Description: Crystal structure of dehydrosqualene synthase complexed with sq-...

2012-03-28T07:26:14Z

New page: '''Unreleased structure''' The entry 4ea2 is ON HOLD Authors: Lin, F.-Y., Li, K., Liu, Y.-L., Oldfield, E. Description: Crystal structure of dehydrosqualene synthase complexed with sq-...

New page

'''Unreleased structure'''

The entry 4ea2 is ON HOLD

Authors: Lin, F.-Y., Li, K., Liu, Y.-L., Oldfield, E.

Description: Crystal structure of dehydrosqualene synthase complexed with sq-109