4ebb - Revision history

OCA at 06:28, 17 October 2024

2024-10-17T06:28:41Z

← Older revision		Revision as of 06:28, 17 October 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [https://pdbe.org/4ebb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [https://www.ebi.ac.uk/pdbsum/4ebb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [https://pdbe.org/4ebb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [https://www.ebi.ac.uk/pdbsum/4ebb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>		[https://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:02, 28 September 2022

2022-09-28T07:02:18Z

← Older revision		Revision as of 07:02, 28 September 2022
Line 1:		Line 1:

	==Structure of DPP2==		==Structure of DPP2==
	<StructureSection load='4ebb' size='340' side='right' caption='[[4ebb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4ebb' size='340' side='right'caption='[[4ebb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [https://pdbe.org/4ebb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [https://www.ebi.ac.uk/pdbsum/4ebb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebb ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>~~
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [~~http~~://pdbe.org/4ebb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ebb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>		[[https://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dipeptidyl-peptidase II~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Human~~]]		[[Category: Large Structures]]
	[[Category: Hassell~~, A H~~]]		[[Category: Hassell AH]]
	[[Category: Johanson~~, K O~~]]		[[Category: Johanson KO]]
	[[Category: Kennedy-Wilson~~, K M~~]]		[[Category: Kennedy-Wilson KM]]
	[[Category: McDevitt~~, P J~~]]		[[Category: McDevitt PJ]]
	[[Category: Shewchuk~~, L M~~]]		[[Category: Shewchuk LM]]
	[[Category: Sweitzer~~, S M~~]]		[[Category: Sweitzer SM]]
	[[Category: Sweitzer~~, T D]]~~		[[Category: Sweitzer TD]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Peptidase~~]]

OCA at 20:18, 5 August 2016

2016-08-05T20:18:22Z

← Older revision		Revision as of 20:18, 5 August 2016
Line 1:		Line 1:

	==Structure of DPP2==		==Structure of DPP2==
	<StructureSection load='4ebb' size='340' side='right' caption='[[4ebb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4ebb' size='340' side='right' caption='[[4ebb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [http://www.ebi.ac.uk/pdbsum/4ebb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [http://pdbe.org/4ebb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [http://www.ebi.ac.uk/pdbsum/4ebb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ebb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Dipeptidyl-peptidase II]]		[[Category: Dipeptidyl-peptidase II]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Hassell, A H]]		[[Category: Hassell, A H]]
	[[Category: Johanson, K O]]		[[Category: Johanson, K O]]

OCA at 21:35, 25 December 2014

2014-12-25T21:35:07Z

← Older revision		Revision as of 21:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [http://www.ebi.ac.uk/pdbsum/4ebb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [http://www.ebi.ac.uk/pdbsum/4ebb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 29:
	[[Category: Dipeptidyl-peptidase II]]		[[Category: Dipeptidyl-peptidase II]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hassell, A H.]]		[[Category: Hassell, A H]]
	[[Category: Johanson, K O.]]		[[Category: Johanson, K O]]
	[[Category: Kennedy-Wilson, K M.]]		[[Category: Kennedy-Wilson, K M]]
	[[Category: McDevitt, P J.]]		[[Category: McDevitt, P J]]
	[[Category: Shewchuk, L M.]]		[[Category: Shewchuk, L M]]
	[[Category: Sweitzer, S M.]]		[[Category: Sweitzer, S M]]
	[[Category: Sweitzer, T D.]]		[[Category: Sweitzer, T D]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peptidase]]		[[Category: Peptidase]]

OCA at 06:47, 25 June 2014

2014-06-25T06:47:27Z

← Older revision		Revision as of 06:47, 25 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ebb~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Structure of DPP2==
			<StructureSection load='4ebb' size='340' side='right' caption='[[4ebb]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jyh\|3jyh]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP7, DPP2, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ebb RCSB], [http://www.ebi.ac.uk/pdbsum/4ebb PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues (DASH). Members of the DASH family have overlapping substrate specificities, and, even though they share low sequence identity, therapeutic or clinical cross-reactivity is a concern. Here, we report the structure of human DPP7 and its complex with a selective inhibitor Dab-Pip (L-2,4-diaminobutyryl-piperidinamide) and compare it with that of DPP4. Both enzymes share a common catalytic domain (alpha/beta-hydrolase). The catalytic pocket is located in the interior of DPP7, deep inside the cleft between the two domains. Substrates might access the active site via a narrow tunnel. The DPP7 catalytic triad is completely conserved and comprises Ser162, Asp418 and His443 (corresponding to Ser630, Asp708 and His740 in DPP4), while other residues lining the catalytic pockets differ considerably. The "specificity domains" are structurally also completely different exhibiting a beta-propeller fold in DPP4 compared to a rare, completely helical fold in DPP7. Comparing the structures of DPP7 and DPP4 allows the design of specific inhibitors and thus the development of less cross-reactive drugs. Furthermore, the reported DPP7 structures shed some light onto the evolutionary relationship of prolyl-specific peptidases through the analysis of the architectural organization of their domains.

	~~{{STRUCTURE_4ebb\| PDB=4ebb \| SCENE= }}~~		Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases.,Bezerra GA, Dobrovetsky E, Dong A, Seitova A, Crombett L, Shewchuk LM, Hassell AM, Sweitzer SM, Sweitzer TD, McDevitt PJ, Johanson KO, Kennedy-Wilson KM, Cossar D, Bochkarev A, Gruber K, Dhe-Paganon S PLoS One. 2012;7(8):e43019. Epub 2012 Aug 29. PMID:22952628<ref>PMID:22952628</ref>

	~~===Structure~~ of ~~DPP2===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_22952628}}~~		==See Also==
			*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
	==~~About this Structure~~==		== References ==
	[[~~4ebb~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Dipeptidyl-peptidase II]]		[[Category: Dipeptidyl-peptidase II]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:11, 19 September 2012

2012-09-19T07:11:59Z

← Older revision		Revision as of 07:11, 19 September 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4ebb.jpg\|left\|200px]]

	~~The entry~~ 4ebb ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4ebb\| PDB=4ebb \| SCENE= }}

	~~Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.~~		===Structure of DPP2===

	~~Description~~: ~~Structure of DPP2~~		{{ABSTRACT_PUBMED_22952628}}

			==About this Structure==
			[[4ebb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBB OCA].
			[[Category: Dipeptidyl-peptidase II]]
			[[Category: Homo sapiens]]
			[[Category: Hassell, A H.]]
			[[Category: Johanson, K O.]]
			[[Category: Kennedy-Wilson, K M.]]
			[[Category: McDevitt, P J.]]
			[[Category: Shewchuk, L M.]]
			[[Category: Sweitzer, S M.]]
			[[Category: Sweitzer, T D.]]
			[[Category: Hydrolase]]
			[[Category: Peptidase]]

OCA at 04:57, 18 July 2012

2012-07-18T04:57:46Z

← Older revision		Revision as of 04:57, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ebb is ON HOLD		The entry 4ebb is ON HOLD until Paper Publication

	Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.		Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.

	Description: Structure of DPP2		Description: Structure of DPP2

OCA at 07:11, 4 July 2012

2012-07-04T07:11:53Z

← Older revision		Revision as of 07:11, 4 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ebb is ON HOLD ~~until Paper Publication~~		The entry 4ebb is ON HOLD

	Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.		Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.

	Description: Structure of DPP2		Description: Structure of DPP2

OCA at 18:53, 2 May 2012

2012-05-02T18:53:58Z

← Older revision		Revision as of 18:53, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ebb is ON HOLD		The entry 4ebb is ON HOLD until Paper Publication

	Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.		Authors: Shewchuk, L.M., Hassell, A.H., Sweitzer, S.M., Sweitzer, T.D., McDevitt, P.J., Kennedy-Wilson, K.M., Johanson, K.O.

	Description: Structure of DPP2		Description: Structure of DPP2

OCA: Protected "4ebb" [edit=sysop:move=sysop]

2012-04-04T05:47:19Z

Protected "4ebb" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:47, 4 April 2012
(No difference)