4eby - Revision history

OCA at 10:47, 6 November 2024

2024-11-06T10:47:50Z

← Older revision		Revision as of 10:47, 6 November 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [https://pdbe.org/4eby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [https://www.ebi.ac.uk/pdbsum/4eby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [https://pdbe.org/4eby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [https://www.ebi.ac.uk/pdbsum/4eby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>		[https://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:03, 28 September 2022

2022-09-28T07:03:31Z

← Older revision		Revision as of 07:03, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the ectodomain of a receptor like kinase==		==Crystal structure of the ectodomain of a receptor like kinase==
	<StructureSection load='4eby' size='340' side='right' caption='[[4eby]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4eby' size='340' side='right'caption='[[4eby]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [https://pdbe.org/4eby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [https://www.ebi.ac.uk/pdbsum/4eby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [~~http~~://pdbe.org/4eby PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eby PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>		[[https://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath~~]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chai, J]]		[[Category: Large Structures]]
	[[Category: Han, Z]]		[[Category: Chai J]]
	[[Category: Liu, T]]		[[Category: Han Z]]
	[[Category: She, J]]		[[Category: Liu T]]
	[[Category: Wang, J]]		[[Category: She J]]
	~~[[Category: Chitin elicitor receptor kinase 1]]~~		[[Category: Wang J]]
	~~[[Category: Chitin oligomer]]~~
	~~[[Category: Lysine motif]]~~
	~~[[Category: Lysm]]~~
	~~[[Category: Pathogen-associated molecular pattern]]~~
	~~[[Category: Pattern recognition receptor]]~~
	~~[[Category: Transferase~~]]

OCA at 05:02, 5 August 2016

2016-08-05T05:02:16Z

← Older revision		Revision as of 05:02, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of the ectodomain of a receptor like kinase==		==Crystal structure of the ectodomain of a receptor like kinase==
	<StructureSection load='4eby' size='340' side='right' caption='[[4eby]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4eby' size='340' side='right' caption='[[4eby]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://pdbe.org/4eby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~A8R7E6_ARATH A8R7E6_ARATH~~]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>		[[http://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eby" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Han, Z]]		[[Category: Han, Z]]

OCA at 23:12, 24 December 2014

2014-12-24T23:12:06Z

← Older revision		Revision as of 23:12, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/A8R7E6_ARATH A8R7E6_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chai, J.]]		[[Category: Chai, J]]
	[[Category: Han, Z.]]		[[Category: Han, Z]]
	[[Category: Liu, T.]]		[[Category: Liu, T]]
	[[Category: She, J]]		[[Category: She, J]]
	[[Category: Wang, J.]]		[[Category: Wang, J]]
	[[Category: Chitin elicitor receptor kinase 1]]		[[Category: Chitin elicitor receptor kinase 1]]
	[[Category: Chitin oligomer]]		[[Category: Chitin oligomer]]

OCA at 08:25, 5 June 2014

2014-06-05T08:25:56Z

← Older revision		Revision as of 08:25, 5 June 2014
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	[[~~Image~~:~~4eby~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Crystal structure of the ectodomain of a receptor like kinase==
			<StructureSection load='4eby' size='340' side='right' caption='[[4eby]], [[Resolution\|resolution]] 1.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ebz\|4ebz]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Pattern recognition receptors confer plant resistance to pathogen infection by recognizing the conserved pathogen-associated molecular patterns. The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain (AtCERK1-ECD) to activate immune responses. The crystal structure that we solved of an AtCERK1-ECD complexed with a chitin pentamer reveals that their interaction is primarily mediated by a LysM and three chitin residues. By acting as a bivalent ligand, a chitin octamer induces AtCERK1-ECD dimerization that is inhibited by shorter chitin oligomers. A mutation attenuating chitin-induced AtCERK1-ECD dimerization or formation of nonproductive AtCERK1 dimer by overexpression of AtCERK1-ECD compromises AtCERK1-mediated signaling in plant cells. Together, our data support the notion that chitin-induced AtCERK1 dimerization is critical for its activation.

	~~{{STRUCTURE_4eby\| PDB=4eby \| SCENE= }}~~		Chitin-induced dimerization activates a plant immune receptor.,Liu T, Liu Z, Song C, Hu Y, Han Z, She J, Fan F, Wang J, Jin C, Chang J, Zhou JM, Chai J Science. 2012 Jun 1;336(6085):1160-4. PMID:22654057<ref>PMID:22654057</ref>

	~~===Crystal structure~~ of the ~~ectodomain of a receptor like kinase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22654057}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4eby]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022654057<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chai, J.]]		[[Category: Chai, J.]]

OCA at 05:46, 27 June 2012

2012-06-27T05:46:20Z

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-'''Unreleased structure'''
+[[Image:4eby.jpg|left|200px]]
-The entry 4eby is ON HOLD  until Paper Publication
+{{STRUCTURE_4eby|  PDB=4eby  |  SCENE=  }}
-Authors: Chai, J., Liu, T., Han, Z., She, J, Wang, J.
+===Crystal structure of the ectodomain of a receptor like kinase===
-Description: Crystal structure of the ectodomain of a receptor like kinase
+{{ABSTRACT_PUBMED_22654057}}

OCA at 08:47, 16 May 2012

2012-05-16T08:47:05Z

← Older revision		Revision as of 08:47, 16 May 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eby is ON HOLD		The entry 4eby is ON HOLD until Paper Publication

	Authors: Chai, J., Liu, T., Han, Z., She, J, Wang, J.		Authors: Chai, J., Liu, T., Han, Z., She, J, Wang, J.

	Description: Crystal structure of the ectodomain of a receptor like kinase		Description: Crystal structure of the ectodomain of a receptor like kinase

OCA at 06:40, 11 April 2012

2012-04-11T06:40:34Z

← Older revision		Revision as of 06:40, 11 April 2012
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	The entry 4eby is ON HOLD		The entry 4eby is ON HOLD

	Authors: Chai ~~jijie~~ , Liu ~~tingting~~, Han ~~zhifu~~, She ji, Wang ~~jiawei~~		Authors: Chai, J., Liu, T., Han, Z., She, J, Wang, J.

	Description: Crystal structure of the ectodomain of a receptor like kinase		Description: Crystal structure of the ectodomain of a receptor like kinase

OCA: Protected "4eby" [edit=sysop:move=sysop]

2012-04-04T05:47:53Z

Protected "4eby" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:47, 4 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4eby is ON HOLD Authors: Chai jijie , Liu tingting, Han zhifu, She ji, Wang jiawei Description: Crystal structure of the ectodomain of a receptor l...

2012-04-04T05:47:52Z

New page: '''Unreleased structure''' The entry 4eby is ON HOLD Authors: Chai jijie , Liu tingting, Han zhifu, She ji, Wang jiawei Description: Crystal structure of the ectodomain of a receptor l...

New page

'''Unreleased structure'''

The entry 4eby is ON HOLD

Authors: Chai jijie , Liu tingting, Han zhifu, She ji, Wang jiawei

Description: Crystal structure of the ectodomain of a receptor like kinase