4ec0 - Revision history

OCA at 11:03, 1 March 2024

2024-03-01T11:03:03Z

← Older revision		Revision as of 11:03, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [https://pdbe.org/4ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [https://pdbe.org/4ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>		[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The inhibition of hH-PGDS has been proposed as a potential target for the development of anti-allergic and anti-inflammatory drugs. Herein we describe our investigation of the binding pocket of this important enzyme and our observation that two water molecules bind to our inhibitors and the enzyme. A series of compounds were prepared to the probe the importance of the water molecules in determining the binding affinity of the inhibitors to the enzyme. The study provides insight into the binding requirements for the design of potent hH-PGDS inhibitors.

	Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters.,Trujillo JI, Kiefer JR, Huang W, Day JE, Moon J, Jerome GM, Bono CP, Kornmeier CM, Williams ML, Kuhn C, Rennie GR, Wynn TA, Carron CP, Thorarensen A Bioorg Med Chem Lett. 2012 Jun 1;22(11):3795-9. Epub 2012 Apr 13. PMID:22546671<ref>PMID:22546671</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==

OCA at 07:03, 28 September 2022

2022-09-28T07:03:49Z

← Older revision		Revision as of 07:03, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of hH-PGDS with water displacing inhibitor==		==Crystal structure of hH-PGDS with water displacing inhibitor==
	<StructureSection load='4ec0' size='340' side='right' caption='[[4ec0]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4ec0' size='340' side='right'caption='[[4ec0]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ee0\|4ee0]], [[4edy\|4edy]], [[4edz\|4edz]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [https://pdbe.org/4ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec0 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTS, HPGDS, PGDS, PTGDS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [~~http~~://pdbe.org/4ec0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ec0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>		[[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Day, J E~~]]		[[Category: Large Structures]]
	[[Category: ~~Thorarensen, A~~]]		[[Category: Day JE]]
	[[Category: ~~Trujillo, J I~~]]		[[Category: Thorarensen A]]
	[[Category: ~~Inhibitor]]~~		[[Category: Trujillo JI]]
	~~[[Category: Isomerase-isomerase inhibitor complex]]~~
	~~[[Category: Solvent replacement~~]]

OCA at 08:01, 15 November 2017

2017-11-15T08:01:31Z

← Older revision		Revision as of 08:01, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Glutathione S-transferase\|Glutathione S-transferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:46, 4 August 2016

2016-08-04T15:46:18Z

← Older revision		Revision as of 15:46, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of hH-PGDS with water displacing inhibitor==		==Crystal structure of hH-PGDS with water displacing inhibitor==
	<StructureSection load='4ec0' size='340' side='right' caption='[[4ec0]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4ec0' size='340' side='right' caption='[[4ec0]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ee0\|4ee0]], [[4edy\|4edy]], [[4edz\|4edz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ee0\|4ee0]], [[4edy\|4edy]], [[4edz\|4edz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTS, HPGDS, PGDS, PTGDS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTS, HPGDS, PGDS, PTGDS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ec0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [http://pdbe.org/4ec0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ec0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ec0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase\|Glutathione S-transferase]]
	*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Day, J E]]		[[Category: Day, J E]]
	[[Category: Thorarensen, A]]		[[Category: Thorarensen, A]]

OCA at 16:37, 24 December 2014

2014-12-24T16:37:41Z

← Older revision		Revision as of 16:37, 24 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ec0~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of hH-PGDS with water displacing inhibitor==
			<StructureSection load='4ec0' size='340' side='right' caption='[[4ec0]], [[Resolution\|resolution]] 1.85Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ec0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EC0 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PQ:4-[2-(AMINOMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>7PQ</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ee0\|4ee0]], [[4edy\|4edy]], [[4edz\|4edz]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTS, HPGDS, PGDS, PTGDS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ec0 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The inhibition of hH-PGDS has been proposed as a potential target for the development of anti-allergic and anti-inflammatory drugs. Herein we describe our investigation of the binding pocket of this important enzyme and our observation that two water molecules bind to our inhibitors and the enzyme. A series of compounds were prepared to the probe the importance of the water molecules in determining the binding affinity of the inhibitors to the enzyme. The study provides insight into the binding requirements for the design of potent hH-PGDS inhibitors.

	~~{{STRUCTURE_4ec0\| PDB=4ec0 \| SCENE= }}~~		Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters.,Trujillo JI, Kiefer JR, Huang W, Day JE, Moon J, Jerome GM, Bono CP, Kornmeier CM, Williams ML, Kuhn C, Rennie GR, Wynn TA, Carron CP, Thorarensen A Bioorg Med Chem Lett. 2012 Jun 1;22(11):3795-9. Epub 2012 Apr 13. PMID:22546671<ref>PMID:22546671</ref>

	~~===Crystal structure~~ of ~~hH-PGDS with water displacing inhibitor===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22546671}}~~

	~~==About this Structure==~~
	~~[[4ec0]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=4EC0 OCA].~~

	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase\|Glutathione S-transferase]]
			*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
	==~~Reference~~==		== References ==
	<~~ref group="xtra">PMID:022546671<~~/~~ref~~><~~references group="xtra"~~/>		<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Day, J E.]]		[[Category: Day, J E]]
	[[Category: Thorarensen, A.]]		[[Category: Thorarensen, A]]
	[[Category: Trujillo, J I.]]		[[Category: Trujillo, J I]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Isomerase-isomerase inhibitor complex]]		[[Category: Isomerase-isomerase inhibitor complex]]
	[[Category: Solvent replacement]]		[[Category: Solvent replacement]]

OCA at 07:23, 2 January 2013

2013-01-02T07:23:10Z

← Older revision		Revision as of 07:23, 2 January 2013
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	[[Image:4ec0.~~jpg~~\|left\|200px]]		[[Image:4ec0.png\|left\|200px]]

	~~<!--~~
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	{{STRUCTURE_4ec0\| PDB=4ec0 \| SCENE= }}		{{STRUCTURE_4ec0\| PDB=4ec0 \| SCENE= }}

	===Crystal structure of hH-PGDS with water displacing inhibitor===		===Crystal structure of hH-PGDS with water displacing inhibitor===


	~~<!--~~
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	{{ABSTRACT_PUBMED_22546671}}		{{ABSTRACT_PUBMED_22546671}}

	==About this Structure==		==About this Structure==
	[[4ec0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA].		[[4ec0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC0 OCA].

			==See Also==
			*[[Glutathione S-transferase\|Glutathione S-transferase]]

	==Reference==		==Reference==

OCA at 09:13, 16 May 2012

2012-05-16T09:13:06Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ec0.jpg|left|200px]]
-The entry 4ec0 is ON HOLD  until Paper Publication
+<!--
-Authors: Day, J.E., Thorarensen, A., Trujillo, J.I.
+===Crystal structure of hH-PGDS with water displacing inhibitor===
-Description: Crystal structure of hH-PGDS with water displacing inhibitor

OCA at 07:30, 18 April 2012

2012-04-18T07:30:23Z

← Older revision		Revision as of 07:30, 18 April 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ec0 is ON HOLD		The entry 4ec0 is ON HOLD until Paper Publication

	Authors: Day, J.E., Thorarensen, A., Trujillo, J.I.		Authors: Day, J.E., Thorarensen, A., Trujillo, J.I.

	Description: Crystal structure of hH-PGDS with water displacing inhibitor		Description: Crystal structure of hH-PGDS with water displacing inhibitor

OCA: Protected "4ec0" [edit=sysop:move=sysop]

2012-04-04T05:47:57Z

Protected "4ec0" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:47, 4 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ec0 is ON HOLD Authors: Day, J.E., Thorarensen, A., Trujillo, J.I. Description: Crystal structure of hH-PGDS with water displacing inhibitor

2012-04-04T05:47:56Z

New page: '''Unreleased structure''' The entry 4ec0 is ON HOLD Authors: Day, J.E., Thorarensen, A., Trujillo, J.I. Description: Crystal structure of hH-PGDS with water displacing inhibitor

New page

'''Unreleased structure'''

The entry 4ec0 is ON HOLD

Authors: Day, J.E., Thorarensen, A., Trujillo, J.I.

Description: Crystal structure of hH-PGDS with water displacing inhibitor