4ece - Revision history

OCA at 11:03, 1 March 2024

2024-03-01T11:03:03Z

← Older revision		Revision as of 11:03, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [https://pdbe.org/4ece PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [https://www.ebi.ac.uk/pdbsum/4ece PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [https://pdbe.org/4ece PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [https://www.ebi.ac.uk/pdbsum/4ece PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>		[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders. Dynamic motion of catalytic site loops has been implicated in catalysis, but experimental evidence was lacking. We replaced catalytic site groups His257 or His64 with 6-fluoro-tryptophan (6FW) as site-specific NMR probes. Conformational adjustments in the 6FW-His257-helical and His64-6FW-loop regions were characterized in PNP phosphate-bound enzyme and in complexes with catalytic site ligands, including transition state analogs. Chemical shift and line-shape changes associated with these complexes revealed dynamic coexistence of several conformational states in these regions in phosphate-bound enzyme and altered or single conformations in other complexes. These conformations were also characterized by X-ray crystallography. Specific (19)F-Trp labels and X-ray crystallography provide multidimensional characterization of conformational states for free, catalytic, and inhibited complexes of human PNP.

	Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.,Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL Chem Biol. 2013 Feb 21;20(2):212-22. doi: 10.1016/j.chembiol.2013.01.009. PMID:23438750<ref>PMID:23438750</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ece" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==

OCA at 07:04, 28 September 2022

2022-09-28T07:04:25Z

← Older revision		Revision as of 07:04, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==		==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==
	<StructureSection load='4ece' size='340' side='right' caption='[[4ece]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4ece' size='340' side='right'caption='[[4ece]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ECE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ear\|4ear]], [[4eb8\|4eb8]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [https://pdbe.org/4ece PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [https://www.ebi.ac.uk/pdbsum/4ece PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP, X00737.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [~~http~~://pdbe.org/4ece PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ece PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[~~http~~://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>		[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:

	==See Also==		==See Also==
	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]		*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Purine-nucleoside phosphorylase~~]]		[[Category: Large Structures]]
	[[Category: Almo~~, S C~~]]		[[Category: Almo SC]]
	[[Category: Haapalainen~~, A M~~]]		[[Category: Haapalainen AM]]
	[[Category: Ho~~, M C~~]]		[[Category: Ho MC]]
	[[Category: Schramm~~, V L~~]]		[[Category: Schramm VL]]
	[[Category: Suarez~~, J J]]~~		[[Category: Suarez JJ]]
	~~[[Category: Cytosol]]~~
	~~[[Category: Drug binding]]~~
	~~[[Category: Guanine]]~~
	~~[[Category: Intracellular]]~~
	~~[[Category: Nucleoside binding]]~~
	~~[[Category: Phosphate ion binding]]~~
	~~[[Category: Pnp]]~~
	~~[[Category: Purine base binding]]~~
	~~[[Category: Purine nucleoside phosphorylase]]~~
	~~[[Category: Purine-nucleoside phosphorylase activity]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Transferring glycosyl group~~]]

OCA at 16:20, 4 August 2016

2016-08-04T16:20:41Z

← Older revision		Revision as of 16:20, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==		==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==
	<StructureSection load='4ece' size='340' side='right' caption='[[4ece]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4ece' size='340' side='right' caption='[[4ece]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ear\|4ear]], [[4eb8\|4eb8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ear\|4ear]], [[4eb8\|4eb8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP, X00737.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP, X00737.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [http://www.ebi.ac.uk/pdbsum/4ece PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [http://pdbe.org/4ece PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [http://www.ebi.ac.uk/pdbsum/4ece PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ece ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ece" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 08:37, 18 December 2014

2014-12-18T08:37:09Z

← Older revision		Revision as of 08:37, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4ece\| PDB=4ece \| SCENE= }}~~		==Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine==
	===Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine===		<StructureSection load='4ece' size='340' side='right' caption='[[4ece]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{ABSTRACT_PUBMED_23438750}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4ece]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECE FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ear\|4ear]], [[4eb8\|4eb8]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP, X00737.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ece FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ece OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ece RCSB], [http://www.ebi.ac.uk/pdbsum/4ece PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders. Dynamic motion of catalytic site loops has been implicated in catalysis, but experimental evidence was lacking. We replaced catalytic site groups His257 or His64 with 6-fluoro-tryptophan (6FW) as site-specific NMR probes. Conformational adjustments in the 6FW-His257-helical and His64-6FW-loop regions were characterized in PNP phosphate-bound enzyme and in complexes with catalytic site ligands, including transition state analogs. Chemical shift and line-shape changes associated with these complexes revealed dynamic coexistence of several conformational states in these regions in phosphate-bound enzyme and altered or single conformations in other complexes. These conformations were also characterized by X-ray crystallography. Specific (19)F-Trp labels and X-ray crystallography provide multidimensional characterization of conformational states for free, catalytic, and inhibited complexes of human PNP.

	~~==About this Structure==~~		Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.,Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL Chem Biol. 2013 Feb 21;20(2):212-22. doi: 10.1016/j.chembiol.2013.01.009. PMID:23438750<ref>PMID:23438750</ref>
	~~[[4ece]] is a 6 chain structure with sequence from [http~~:/~~/en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4ECE OCA~~].
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
			*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C]]
	[[Category: Haapalainen, A M.]]		[[Category: Haapalainen, A M]]
	[[Category: Ho, M C.]]		[[Category: Ho, M C]]
	[[Category: Schramm, V L.]]		[[Category: Schramm, V L]]
	[[Category: Suarez, J J.]]		[[Category: Suarez, J J]]
	[[Category: Cytosol]]		[[Category: Cytosol]]
	[[Category: Drug binding]]		[[Category: Drug binding]]

OCA at 09:13, 13 March 2013

2013-03-13T09:13:48Z

← Older revision		Revision as of 09:13, 13 March 2013
Line 1:		Line 1:
	~~[[Image:4ece.png\|left\|200px]]~~

	{{STRUCTURE_4ece\| PDB=4ece \| SCENE= }}		{{STRUCTURE_4ece\| PDB=4ece \| SCENE= }}

	===Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine===		===Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine===
			{{ABSTRACT_PUBMED_23438750}}

	==About this Structure==		==About this Structure==

OCA at 12:47, 6 March 2013

2013-03-06T12:47:53Z

← Older revision		Revision as of 12:47, 6 March 2013
Line 1:		Line 1:
	[[Image:4ece.~~jpg~~\|left\|200px]]		[[Image:4ece.png\|left\|200px]]

	{{STRUCTURE_4ece\| PDB=4ece \| SCENE= }}		{{STRUCTURE_4ece\| PDB=4ece \| SCENE= }}

OCA at 13:05, 6 February 2013

2013-02-06T13:05:07Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ece.jpg|left|200px]]
-The entry 4ece is ON HOLD  until Paper Publication
+{{STRUCTURE_4ece|  PDB=4ece  |  SCENE=  }}
-Authors: Haapalainen, A.M., Ho, M.C., Suarez, J.J., Almo, S.C., Schramm, V.L.
+===Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine===
-Description: Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine

OCA: Protected "4ece" [edit=sysop:move=sysop]

2012-04-04T05:48:17Z

Protected "4ece" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:48, 4 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ece is ON HOLD until Paper Publication Authors: Haapalainen, A.M., Ho, M.C., Suarez, J.J., Almo, S.C., Schramm, V.L. Description: Crystal structur...

2012-04-04T05:48:16Z

New page: '''Unreleased structure''' The entry 4ece is ON HOLD until Paper Publication Authors: Haapalainen, A.M., Ho, M.C., Suarez, J.J., Almo, S.C., Schramm, V.L. Description: Crystal structur...

New page

'''Unreleased structure'''

The entry 4ece is ON HOLD until Paper Publication

Authors: Haapalainen, A.M., Ho, M.C., Suarez, J.J., Almo, S.C., Schramm, V.L.

Description: Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine