4ecl - Revision history

OCA at 10:47, 6 November 2024

2024-11-06T10:47:55Z

← Older revision		Revision as of 10:47, 6 November 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.017Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [https://pdbe.org/4ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [https://www.ebi.ac.uk/pdbsum/4ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ecl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [https://pdbe.org/4ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [https://www.ebi.ac.uk/pdbsum/4ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ecl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q6WRY3_ENTFL Q6WRY3_ENTFL]]		[https://www.uniprot.org/uniprot/Q6WRY3_ENTFL Q6WRY3_ENTFL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:04, 28 September 2022

2022-09-28T07:04:49Z

← Older revision		Revision as of 07:04, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg==		==Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg==
	<StructureSection load='4ecl' size='340' side='right' caption='[[4ecl]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='4ecl' size='340' side='right'caption='[[4ecl]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ECL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [https://pdbe.org/4ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [https://www.ebi.ac.uk/pdbsum/4ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ecl ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [~~http~~://pdbe.org/4ecl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/Q6WRY3_ENTFL Q6WRY3_ENTFL]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus ~~proteiformis thiercelin and jouhaud 1903~~]]		[[Category: Enterococcus faecalis]]
	[[Category: ~~Anderson, W F~~]]		[[Category: Large Structures]]
	[[Category: ~~Structural genomic~~]]		[[Category: Anderson WF]]
	[[Category: Cosme, J]]		[[Category: Cosme J]]
	[[Category: Courvalin, P]]		[[Category: Courvalin P]]
	[[Category: ~~Egorova, O~~]]		[[Category: Di Leo R]]
	[[Category: ~~Evdokimova, E~~]]		[[Category: Egorova O]]
	[[Category: ~~Krishnamoorthy, M~~]]		[[Category: Evdokimova E]]
	[[Category: ~~Leo, R Di~~]]		[[Category: Krishnamoorthy M]]
	[[Category: Meziane-Cherif, D]]		[[Category: Meziane-Cherif D]]
	[[Category: Minasov, G]]		[[Category: Minasov G]]
	[[Category: Savchenko, A]]		[[Category: Savchenko A]]
	[[Category: Stogios~~, P J~~]]		[[Category: Stogios PJ]]
	[[Category: Wawrzak, Z]]		[[Category: Wawrzak Z]]
	~~[[Category: Acyltransferase family]]~~
	~~[[Category: Alpha/beta barrel]]~~
	~~[[Category: Antibiotic resistance]]~~
	~~[[Category: Cytoplasmic]]~~
	~~[[Category: D-serine]]~~
	~~[[Category: D-serine racemase]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: L-serine]]~~
	~~[[Category: L-serine racemase]]~~
	~~[[Category: Plp]]~~
	~~[[Category: Pyridoxal 5-phosphate]]~~
	~~[[Category: Tim barrel]]~~
	~~[[Category: Vancomycin resistance~~]]

OCA at 07:30, 1 June 2016

2016-06-01T07:30:29Z

← Older revision		Revision as of 07:30, 1 June 2016
Line 1:		Line 1:

	==Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg==		==Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg==
	<StructureSection load='4ecl' size='340' side='right' caption='[[4ecl]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='4ecl' size='340' side='right' caption='[[4ecl]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_faecalis Enterococcus faecalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus ~~faecalis~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [http://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [http://pdbe.org/4ecl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [http://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Vancomycin resistance in Gram-positive bacteria results from the replacement of the D-alanyl-D-alanine target of peptidoglycan precursors with D-alanyl-D-lactate or D-alanyl-D-serine (D-Ala-D-Ser), to which vancomycin has low binding affinity. VanT is one of the proteins required for the production of D-Ala-D-Ser-terminating precursors by converting L-Ser to D-Ser. VanT is composed of two domains, an N-terminal membrane-bound domain, likely involved in L-Ser uptake, and a C-terminal cytoplasmic catalytic domain which is related to bacterial alanine racemases. To gain insight into the molecular function of VanT, the crystal structure of the catalytic domain of VanTG from VanG-type resistant Enterococcus faecalis BM4518 was determined. The structure showed significant similarity to type III pyridoxal 5'-phosphate (PLP)-dependent alanine racemases, which are essential for peptidoglycan synthesis. Comparative structural analysis between VanTG and alanine racemases as well as site-directed mutagenesis identified three specific active site positions centered around Asn696 which are responsible for the L-amino acid specificity. This analysis also suggested that VanT racemases evolved from regular alanine racemases by acquiring additional selectivity toward serine while preserving that for alanine. The 4-fold-lower relative catalytic efficiency of VanTG against L-Ser versus L-Ala implied that this enzyme relies on its membrane-bound domain for L-Ser transport to increase the overall rate of d-Ser production. These findings illustrate how vancomycin pressure selected for molecular adaptation of a housekeeping enzyme to a bifunctional enzyme to allow for peptidoglycan remodeling, a strategy increasingly observed in antibiotic-resistant bacteria. IMPORTANCE: Vancomycin is one of the drugs of last resort against Gram-positive antibiotic-resistant pathogens. However, bacteria have evolved a sophisticated mechanism which remodels the drug target, the D-alanine ending precursors in cell wall synthesis, into precursors terminating with D-lactate or D-serine, to which vancomycin has less affinity. D-Ser is synthesized by VanT serine racemase, which has two unusual characteristics: (i) it is one of the few serine racemases identified in bacteria and (ii) it contains a membrane-bound domain involved in L-Ser uptake. The structure of the catalytic domain of VanTG showed high similarity to alanine racemases, and we identified three specific active site substitutions responsible for L-Ser specificity. The data provide the molecular basis for VanT evolution to a bifunctional enzyme coordinating both transport and racemization. Our findings also illustrate the evolution of the essential alanine racemase into a vancomycin resistance enzyme in response to antibiotic pressure.

			Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases.,Meziane-Cherif D, Stogios PJ, Evdokimova E, Egorova O, Savchenko A, Courvalin P MBio. 2015 Aug 11;6(4):e00806. doi: 10.1128/mBio.00806-15. PMID:26265719<ref>PMID:26265719</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4ecl" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus ~~faecalis~~]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 13:35, 4 January 2015

2015-01-04T13:35:09Z

← Older revision		Revision as of 13:35, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECL FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [http://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [http://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>
	<table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F]]
	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]		[[Category: Structural genomic]]
	[[Category: Cosme, J.]]		[[Category: Cosme, J]]
	[[Category: Courvalin, P.]]		[[Category: Courvalin, P]]
	[[Category: Egorova, O.]]		[[Category: Egorova, O]]
	[[Category: Evdokimova, E.]]		[[Category: Evdokimova, E]]
	[[Category: Krishnamoorthy, M.]]		[[Category: Krishnamoorthy, M]]
	[[Category: Leo, R Di.]]		[[Category: Leo, R Di]]
	[[Category: Meziane-Cherif, D.]]		[[Category: Meziane-Cherif, D]]
	[[Category: Minasov, G.]]		[[Category: Minasov, G]]
	[[Category: Savchenko, A.]]		[[Category: Savchenko, A]]
	[[Category: Stogios, P J.]]		[[Category: Stogios, P J]]
	[[Category: Wawrzak, Z.]]		[[Category: Wawrzak, Z]]
	[[Category: Acyltransferase family]]		[[Category: Acyltransferase family]]
	[[Category: Alpha/beta barrel]]		[[Category: Alpha/beta barrel]]

OCA at 07:16, 5 June 2014

2014-06-05T07:16:37Z

← Older revision		Revision as of 07:16, 5 June 2014
Line 1:		Line 1:
	~~[[Image:4ecl.jpg\|left\|200px]]~~		==Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg==
			<StructureSection load='4ecl' size='340' side='right' caption='[[4ecl]], [[Resolution\|resolution]] 2.02Å' scene=''>
	~~<!--~~		== Structural highlights ==
	~~The line below this paragraph, containing "STRUCTURE_4ecl", creates the "Structure Box" on the page.~~		<table><tr><td colspan='2'>[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ECL FirstGlance]. <br>
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~		<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	~~or leave the SCENE parameter empty for the default display.~~		<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vanTG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
	~~-->~~		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ecl RCSB], [http://www.ebi.ac.uk/pdbsum/4ecl PDBsum]</span></td></tr>
	~~{{STRUCTURE_4ecl\| PDB=4ecl \| SCENE= }}~~		<table>
			__TOC__
	===Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg===		</StructureSection>


	==~~About this Structure~~==
	[[4ecl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECL OCA].
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 08:01, 18 April 2012

2012-04-18T08:01:50Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ecl.jpg|left|200px]]
-The entry 4ecl is ON HOLD
+<!--
-Authors: Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Cosme, J., Di Leo, R., Krishnamoorthy, M., Meziane-Cherif, D., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
+===Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg===
-Description: Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg

OCA: Protected "4ecl" [edit=sysop:move=sysop]

2012-04-04T05:48:29Z

Protected "4ecl" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:48, 4 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ecl is ON HOLD Authors: Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Cosme, J., Di Leo, R., Krishnamoorthy, M., Meziane-Ch...

2012-04-04T05:48:28Z

New page: '''Unreleased structure''' The entry 4ecl is ON HOLD Authors: Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Cosme, J., Di Leo, R., Krishnamoorthy, M., Meziane-Ch...

New page

'''Unreleased structure'''

The entry 4ecl is ON HOLD

Authors: Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Cosme, J., Di Leo, R., Krishnamoorthy, M., Meziane-Cherif, D., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Crystal structure of the cytoplasmic domain of vancomycin resistance serine racemase VanTg