4eee - Revision history

OCA at 02:49, 21 November 2024

2024-11-21T02:49:46Z

← Older revision		Revision as of 02:49, 21 November 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q9DHU8_YLDV Q9DHU8_YLDV]		[https://www.uniprot.org/uniprot/Q9DHU8_YLDV Q9DHU8_YLDV]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative feedback mechanism. Many poxviruses encode homologous IL18BPs, which contribute to virulence. Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs. The aromatic residues are conserved among the very diverse mammalian and poxviruses IL18BPs with the notable exception of yatapoxvirus IL18BPs, which lack a critical phenylalanine residue. To understand the mechanism by which yatapoxvirus IL18BPs neutralize IL18, we solved the crystal structure of the Yaba-Like Disease Virus (YLDV) IL18BP and IL18 complex at 1.75 A resolution. YLDV-IL18BP forms a disulfide bonded homo-dimer engaging IL18 in a 2ratio2 stoichiometry, in contrast to the 1ratio1 complex of ectromelia virus (ECTV) IL18BP and IL18. Disruption of the dimer interface resulted in a functional monomer, however with a 3-fold decrease in binding affinity. The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction. Through structural and mutagenesis studies, contact residues that are unique to the YLDV-IL18BP:IL18 binding interface were identified, including Q67, P116 of YLDV-IL18BP and Y1, S105 and D110 of IL18. Overall, our studies show that YLDV-IL18BP is unique among the diverse family of mammalian and poxvirus IL-18BPs in that it uses a bivalent binding mode and a unique set of interacting residues for binding IL18. However, despite this extensive divergence, YLDV-IL18BP binds to the same surface of IL18 used by other IL18BPs, suggesting that all IL18BPs use a conserved inhibitory mechanism by blocking a putative receptor-binding site on IL18.

			A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.,Krumm B, Meng X, Wang Z, Xiang Y, Deng J PLoS Pathog. 2012 Aug;8(8):e1002876. Epub 2012 Aug 23. PMID:22927815<ref>PMID:22927815</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4eee" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Interleukin 3D structures\|Interleukin 3D structures]]		*[[Interleukin 3D structures\|Interleukin 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:59, 14 March 2024

2024-03-14T14:59:06Z

← Older revision		Revision as of 14:59, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [https://pdbe.org/4eee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [https://www.ebi.ac.uk/pdbsum/4eee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eee ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [https://pdbe.org/4eee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [https://www.ebi.ac.uk/pdbsum/4eee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eee ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q9DHU8_YLDV Q9DHU8_YLDV]]		[https://www.uniprot.org/uniprot/Q9DHU8_YLDV Q9DHU8_YLDV]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative feedback mechanism. Many poxviruses encode homologous IL18BPs, which contribute to virulence. Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs. The aromatic residues are conserved among the very diverse mammalian and poxviruses IL18BPs with the notable exception of yatapoxvirus IL18BPs, which lack a critical phenylalanine residue. To understand the mechanism by which yatapoxvirus IL18BPs neutralize IL18, we solved the crystal structure of the Yaba-Like Disease Virus (YLDV) IL18BP and IL18 complex at 1.75 A resolution. YLDV-IL18BP forms a disulfide bonded homo-dimer engaging IL18 in a 2ratio2 stoichiometry, in contrast to the 1ratio1 complex of ectromelia virus (ECTV) IL18BP and IL18. Disruption of the dimer interface resulted in a functional monomer, however with a 3-fold decrease in binding affinity. The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction. Through structural and mutagenesis studies, contact residues that are unique to the YLDV-IL18BP:IL18 binding interface were identified, including Q67, P116 of YLDV-IL18BP and Y1, S105 and D110 of IL18. Overall, our studies show that YLDV-IL18BP is unique among the diverse family of mammalian and poxvirus IL-18BPs in that it uses a bivalent binding mode and a unique set of interacting residues for binding IL18. However, despite this extensive divergence, YLDV-IL18BP binds to the same surface of IL18 used by other IL18BPs, suggesting that all IL18BPs use a conserved inhibitory mechanism by blocking a putative receptor-binding site on IL18.

	A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.,Krumm B, Meng X, Wang Z, Xiang Y, Deng J PLoS Pathog. 2012 Aug;8(8):e1002876. Epub 2012 Aug 23. PMID:22927815<ref>PMID:22927815</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4eee" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Interleukin 3D structures\|Interleukin 3D structures]]		*[[Interleukin 3D structures\|Interleukin 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:07, 28 September 2022

2022-09-28T07:07:37Z

← Older revision		Revision as of 07:07, 28 September 2022
Line 1:		Line 1:

	==Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18==		==Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18==
	<StructureSection load='4eee' size='340' side='right' caption='[[4eee]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='4eee' size='340' side='right'caption='[[4eee]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Tanapox_virus_strain_davis Tanapox~~ virus ~~strain davis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EEE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EEE FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ekx\|4ekx]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [https://pdbe.org/4eee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [https://www.ebi.ac.uk/pdbsum/4eee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eee ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">14L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=132475 Tanapox virus strain Davis]), IGIF, IL-18, IL18, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [~~http~~://pdbe.org/4eee PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eee PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eee ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/~~IL18_HUMAN IL18_HUMAN~~]] ~~Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.~~		[[https://www.uniprot.org/uniprot/Q9DHU8_YLDV Q9DHU8_YLDV]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Tanapox virus strain davis~~]]		[[Category: Large Structures]]
	[[Category: ~~Deng, J]]~~		[[Category: Yaba-like disease virus]]
	~~[[Category: Krumm, B E]]~~		[[Category: Deng J]]
	~~[[Category: Xiang, Y]]~~		[[Category: Krumm BE]]
	~~[[Category: Beta trefoil]]~~		[[Category: Xiang Y]]
	~~[[Category: Cytokine signaling]]~~
	~~[[Category: Cytokine~~-~~viral protein complex~~]]
	[[Category: ~~Immunoglobulin fold~~]]
	[[Category: ~~Interleukin-18 binding protein~~]]
	[[Category: ~~Yaba]]~~
	~~[[Category: Yldv~~]]

OCA at 04:11, 5 August 2016

2016-08-05T04:11:48Z

← Older revision		Revision as of 04:11, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18==		==Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18==
	<StructureSection load='4eee' size='340' side='right' caption='[[4eee]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='4eee' size='340' side='right' caption='[[4eee]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EEE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Tanapox_virus_strain_davis Tanapox virus strain davis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EEE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ekx\|4ekx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ekx\|4ekx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">14L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10239 Viruses~~]), IGIF, IL-18, IL18, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">14L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=132475 Tanapox virus strain Davis]), IGIF, IL-18, IL18, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [http://www.ebi.ac.uk/pdbsum/4eee PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [http://pdbe.org/4eee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [http://www.ebi.ac.uk/pdbsum/4eee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eee ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eee" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: ~~Viruses~~]]		[[Category: Tanapox virus strain davis]]
	[[Category: Deng, J]]		[[Category: Deng, J]]
	[[Category: Krumm, B E]]		[[Category: Krumm, B E]]

OCA at 15:43, 25 December 2014

2014-12-25T15:43:49Z

← Older revision		Revision as of 15:43, 25 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4eee~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18==
			<StructureSection load='4eee' size='340' side='right' caption='[[4eee]], [[Resolution\|resolution]] 2.71Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EEE FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ekx\|4ekx]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">14L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses]), IGIF, IL-18, IL18, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eee RCSB], [http://www.ebi.ac.uk/pdbsum/4eee PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative feedback mechanism. Many poxviruses encode homologous IL18BPs, which contribute to virulence. Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs. The aromatic residues are conserved among the very diverse mammalian and poxviruses IL18BPs with the notable exception of yatapoxvirus IL18BPs, which lack a critical phenylalanine residue. To understand the mechanism by which yatapoxvirus IL18BPs neutralize IL18, we solved the crystal structure of the Yaba-Like Disease Virus (YLDV) IL18BP and IL18 complex at 1.75 A resolution. YLDV-IL18BP forms a disulfide bonded homo-dimer engaging IL18 in a 2ratio2 stoichiometry, in contrast to the 1ratio1 complex of ectromelia virus (ECTV) IL18BP and IL18. Disruption of the dimer interface resulted in a functional monomer, however with a 3-fold decrease in binding affinity. The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction. Through structural and mutagenesis studies, contact residues that are unique to the YLDV-IL18BP:IL18 binding interface were identified, including Q67, P116 of YLDV-IL18BP and Y1, S105 and D110 of IL18. Overall, our studies show that YLDV-IL18BP is unique among the diverse family of mammalian and poxvirus IL-18BPs in that it uses a bivalent binding mode and a unique set of interacting residues for binding IL18. However, despite this extensive divergence, YLDV-IL18BP binds to the same surface of IL18 used by other IL18BPs, suggesting that all IL18BPs use a conserved inhibitory mechanism by blocking a putative receptor-binding site on IL18.

	~~{{STRUCTURE_4eee\| PDB=4eee \| SCENE= }}~~		A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.,Krumm B, Meng X, Wang Z, Xiang Y, Deng J PLoS Pathog. 2012 Aug;8(8):e1002876. Epub 2012 Aug 23. PMID:22927815<ref>PMID:22927815</ref>

	~~===Crystal Structure~~ of ~~YLDV 14L IL-18 Binding Protein in Complex with Human IL-18===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_22927815}}~~		==See Also==
			*[[Interleukin\|Interleukin]]
	==~~About this Structure~~==		== References ==
	[[~~4eee~~]] ~~is a 4 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA].		<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Deng, J.]]		[[Category: Deng, J]]
	[[Category: Krumm, B E.]]		[[Category: Krumm, B E]]
	[[Category: Xiang, Y.]]		[[Category: Xiang, Y]]
	[[Category: Beta trefoil]]		[[Category: Beta trefoil]]
	[[Category: Cytokine signaling]]		[[Category: Cytokine signaling]]

OCA at 20:28, 26 September 2012

2012-09-26T20:28:38Z

← Older revision		Revision as of 20:28, 26 September 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4eee.jpg\|left\|200px]]

	~~The entry~~ 4eee ~~is ON HOLD~~		{{STRUCTURE_4eee\| PDB=4eee \| SCENE= }}

	~~Authors: Krumm, B.E., Xiang, Y., Deng, J.~~		===Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18===

	~~Description~~: ~~Crystal Structure of YLDV 14L IL~~-~~18 Binding Protein in Complex with Human IL~~-18		{{ABSTRACT_PUBMED_22927815}}

			==About this Structure==
			[[4eee]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEE OCA].
			[[Category: Homo sapiens]]
			[[Category: Viruses]]
			[[Category: Deng, J.]]
			[[Category: Krumm, B E.]]
			[[Category: Xiang, Y.]]
			[[Category: Beta trefoil]]
			[[Category: Cytokine signaling]]
			[[Category: Cytokine-viral protein complex]]
			[[Category: Immunoglobulin fold]]
			[[Category: Interleukin-18 binding protein]]
			[[Category: Yaba]]
			[[Category: Yldv]]

OCA at 06:46, 19 September 2012

2012-09-19T06:46:52Z

← Older revision		Revision as of 06:46, 19 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eee is ON HOLD ~~until Paper Publication~~		The entry 4eee is ON HOLD

	Authors: Krumm, B.E., Xiang, Y., Deng, J.		Authors: Krumm, B.E., Xiang, Y., Deng, J.

	Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18		Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18

OCA at 04:57, 18 July 2012

2012-07-18T04:57:59Z

← Older revision		Revision as of 04:57, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eee is ON HOLD until ~~sometime in the future~~		The entry 4eee is ON HOLD until Paper Publication

	Authors: Krumm, B.E., Xiang, Y., Deng, J.		Authors: Krumm, B.E., Xiang, Y., Deng, J.

	Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18		Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18

OCA at 07:19, 20 June 2012

2012-06-20T07:19:57Z

← Older revision		Revision as of 07:19, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eee is ON HOLD		The entry 4eee is ON HOLD until sometime in the future

	Authors: Krumm, B.E., Xiang, Y., Deng, J.		Authors: Krumm, B.E., Xiang, Y., Deng, J.

	Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18		Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18

OCA: Protected "4eee" [edit=sysop:move=sysop]

2012-04-04T05:50:22Z

Protected "4eee" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:50, 4 April 2012
(No difference)