4efa - Revision history

OCA at 15:00, 14 March 2024

2024-03-14T15:00:05Z

← Older revision		Revision as of 15:00, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8163Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [https://pdbe.org/4efa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [https://www.ebi.ac.uk/pdbsum/4efa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [https://pdbe.org/4efa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [https://www.ebi.ac.uk/pdbsum/4efa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/VATC_YEAST VATC_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:10781598</ref>		[https://www.uniprot.org/uniprot/VATC_YEAST VATC_YEAST] Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:10781598</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Vacuolar ATPases (V-ATPases) are multisubunit rotary motor proton pumps that function to acidify subcellular organelles in all eukaryotic organisms. V-ATPase is regulated by a unique mechanism that involves reversible dissociation into V(1)-ATPase and V(o) proton channel, a process that involves breaking of protein interactions mediated by subunit C, the cytoplasmic domain of subunit "a" and three "peripheral stalks," each made of a heterodimer of E and G subunits. Here, we present crystal structures of a yeast V-ATPase heterotrimeric complex composed of EG heterodimer and the head domain of subunit C (C(head)). The structures show EG heterodimer folded in a noncanonical coiled coil that is stabilized at its N-terminal ends by binding to C(head). The coiled coil is disrupted by a bulge of partially unfolded secondary structure in subunit G and we speculate that this unique feature in the eukaryotic V-ATPase peripheral stalk may play an important role in enzyme structure and regulation by reversible dissociation.

	Crystal Structure of the Yeast Vacuolar ATPase Heterotrimeric EGC(head) Peripheral Stalk Complex.,Oot RA, Huang LS, Berry EA, Wilkens S Structure. 2012 Sep 18. pii: S0969-2126(12)00321-8. doi:, 10.1016/j.str.2012.08.020. PMID:23000382<ref>PMID:23000382</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==

OCA at 07:08, 28 September 2022

2022-09-28T07:08:44Z

← Older revision		Revision as of 07:08, 28 September 2022
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	==Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation==		==Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation==
	<StructureSection load='4efa' size='340' side='right' caption='[[4efa]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='4efa' size='340' side='right'caption='[[4efa]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dl0\|4dl0]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [https://pdbe.org/4efa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [https://www.ebi.ac.uk/pdbsum/4efa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efa ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAT3, VATC, VMA5, YKL080W, YKL410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), VMA10, YHR039BC, YHR039C-A, YHR039C-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), O6241, VAT5, VMA4, YOR332W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [~~http~~://pdbe.org/4efa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4efa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4efa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/VATC_YEAST VATC_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:10781598</ref> [[http://www.uniprot.org/uniprot/VATE_YEAST VATE_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. [[http://www.uniprot.org/uniprot/VATG_YEAST VATG_YEAST]] Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.		[[https://www.uniprot.org/uniprot/VATC_YEAST VATC_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:10781598</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Baker's yeast~~]]		[[Category: Large Structures]]
	[[Category: ~~Berry, E A~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: ~~Huang, L S~~]]		[[Category: Berry EA]]
	[[Category: ~~Oot, R A~~]]		[[Category: Huang LS]]
	[[Category: ~~Wilkens, S~~]]		[[Category: Oot RA]]
	[[Category: ~~Heterotrimer]]~~		[[Category: Wilkens S]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Peripheral stalk]]~~
	~~[[Category: Vacuolar atpase~~]]

OCA at 08:03, 15 November 2017

2017-11-15T08:03:04Z

← Older revision		Revision as of 08:03, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[ATPase\|ATPase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:19, 5 August 2016

2016-08-05T02:19:20Z

← Older revision		Revision as of 02:19, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation==		==Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation==
	<StructureSection load='4efa' size='340' side='right' caption='[[4efa]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='4efa' size='340' side='right' caption='[[4efa]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dl0\|4dl0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dl0\|4dl0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAT3, VATC, VMA5, YKL080W, YKL410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), VMA10, YHR039BC, YHR039C-A, YHR039C-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), O6241, VAT5, VMA4, YOR332W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAT3, VATC, VMA5, YKL080W, YKL410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), VMA10, YHR039BC, YHR039C-A, YHR039C-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), O6241, VAT5, VMA4, YOR332W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [http://www.ebi.ac.uk/pdbsum/4efa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [http://pdbe.org/4efa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [http://www.ebi.ac.uk/pdbsum/4efa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4efa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4efa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae s288c~~]]		[[Category: Baker's yeast]]
	[[Category: Berry, E A]]		[[Category: Berry, E A]]
	[[Category: Huang, L S]]		[[Category: Huang, L S]]

OCA at 21:58, 24 December 2014

2014-12-24T21:58:39Z

← Older revision		Revision as of 21:58, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [http://www.ebi.ac.uk/pdbsum/4efa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [http://www.ebi.ac.uk/pdbsum/4efa PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/VATC_YEAST VATC_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:10781598</ref> [[http://www.uniprot.org/uniprot/VATE_YEAST VATE_YEAST]] Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. [[http://www.uniprot.org/uniprot/VATG_YEAST VATG_YEAST]] Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:44, 9 December 2014

2014-12-09T17:44:39Z

← Older revision		Revision as of 17:44, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4efa~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation==
			<StructureSection load='4efa' size='340' side='right' caption='[[4efa]], [[Resolution\|resolution]] 2.82Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4efa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFA FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dl0\|4dl0]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAT3, VATC, VMA5, YKL080W, YKL410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), VMA10, YHR039BC, YHR039C-A, YHR039C-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), O6241, VAT5, VMA4, YOR332W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efa RCSB], [http://www.ebi.ac.uk/pdbsum/4efa PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Vacuolar ATPases (V-ATPases) are multisubunit rotary motor proton pumps that function to acidify subcellular organelles in all eukaryotic organisms. V-ATPase is regulated by a unique mechanism that involves reversible dissociation into V(1)-ATPase and V(o) proton channel, a process that involves breaking of protein interactions mediated by subunit C, the cytoplasmic domain of subunit "a" and three "peripheral stalks," each made of a heterodimer of E and G subunits. Here, we present crystal structures of a yeast V-ATPase heterotrimeric complex composed of EG heterodimer and the head domain of subunit C (C(head)). The structures show EG heterodimer folded in a noncanonical coiled coil that is stabilized at its N-terminal ends by binding to C(head). The coiled coil is disrupted by a bulge of partially unfolded secondary structure in subunit G and we speculate that this unique feature in the eukaryotic V-ATPase peripheral stalk may play an important role in enzyme structure and regulation by reversible dissociation.

	~~{{STRUCTURE_4efa\| PDB=4efa \| SCENE= }}~~		Crystal Structure of the Yeast Vacuolar ATPase Heterotrimeric EGC(head) Peripheral Stalk Complex.,Oot RA, Huang LS, Berry EA, Wilkens S Structure. 2012 Sep 18. pii: S0969-2126(12)00321-8. doi:, 10.1016/j.str.2012.08.020. PMID:23000382<ref>PMID:23000382</ref>

	~~===Crystal Structure~~ of the ~~Heterotrimeric EGChead Peripheral Stalk Complex~~ of ~~the Yeast Vacuolar ATPase - second conformation===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23000382}}~~		==See Also==
			*[[ATPase\|ATPase]]
	==~~About this Structure~~==		== References ==
	[[~~4efa~~]] ~~is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Berry, E A.]]		[[Category: Berry, E A]]
	[[Category: Huang, L S.]]		[[Category: Huang, L S]]
	[[Category: Oot, R A.]]		[[Category: Oot, R A]]
	[[Category: Wilkens, S.]]		[[Category: Wilkens, S]]
	[[Category: Heterotrimer]]		[[Category: Heterotrimer]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peripheral stalk]]		[[Category: Peripheral stalk]]
	[[Category: Vacuolar atpase]]		[[Category: Vacuolar atpase]]

OCA at 14:45, 28 November 2012

2012-11-28T14:45:08Z

← Older revision		Revision as of 14:45, 28 November 2012
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	[[Image:4efa.~~jpg~~\|left\|200px]]		[[Image:4efa.png\|left\|200px]]

	{{STRUCTURE_4efa\| PDB=4efa \| SCENE= }}		{{STRUCTURE_4efa\| PDB=4efa \| SCENE= }}
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[4efa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA].		[[4efa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA].
			[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Berry, E A.]]		[[Category: Berry, E A.]]
	[[Category: Huang, L S.]]		[[Category: Huang, L S.]]

OCA at 07:18, 10 October 2012

2012-10-10T07:18:07Z

← Older revision		Revision as of 07:18, 10 October 2012
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	~~'''Unreleased structure'''~~		[[Image:4efa.jpg\|left\|200px]]

	~~The entry~~ 4efa ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4efa\| PDB=4efa \| SCENE= }}

	~~Authors: Oot, R.A., Huang, L.S., Berry, E.A., Wilkens, S.~~		===Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation===

	~~Description~~:		{{ABSTRACT_PUBMED_23000382}}

			==About this Structure==
			[[4efa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFA OCA].
			[[Category: Berry, E A.]]
			[[Category: Huang, L S.]]
			[[Category: Oot, R A.]]
			[[Category: Wilkens, S.]]
			[[Category: Heterotrimer]]
			[[Category: Hydrolase]]
			[[Category: Peripheral stalk]]
			[[Category: Vacuolar atpase]]

OCA at 06:41, 11 April 2012

2012-04-11T06:41:36Z

← Older revision		Revision as of 06:41, 11 April 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4efa is ON HOLD		The entry 4efa is ON HOLD until Paper Publication

	Authors: Oot, R.A., Huang, L.S., Berry, E.A., Wilkens, S.		Authors: Oot, R.A., Huang, L.S., Berry, E.A., Wilkens, S.

	Description:		Description:

OCA: Protected "4efa" [edit=sysop:move=sysop]

2012-04-04T05:51:23Z

Protected "4efa" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:51, 4 April 2012
(No difference)