4ehh - Revision history

OCA at 06:29, 17 October 2024

2024-10-17T06:29:05Z

← Older revision		Revision as of 06:29, 17 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [https://pdbe.org/4ehh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [https://www.ebi.ac.uk/pdbsum/4ehh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [https://pdbe.org/4ehh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [https://www.ebi.ac.uk/pdbsum/4ehh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>		[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:11, 28 September 2022

2022-09-28T07:11:30Z

← Older revision		Revision as of 07:11, 28 September 2022
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	==Allosteric Modulation of Caspase-3 through Mutagenesis==		==Allosteric Modulation of Caspase-3 through Mutagenesis==
	<StructureSection load='4ehh' size='340' side='right' caption='[[4ehh]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4ehh' size='340' side='right'caption='[[4ehh]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHH FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [https://pdbe.org/4ehh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [https://www.ebi.ac.uk/pdbsum/4ehh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehh ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [~~http~~://pdbe.org/4ehh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ehh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>		[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4ehh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ehh" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Caspase-3~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Human~~]]		[[Category: Large Structures]]
	[[Category: Clark~~, A C~~]]		[[Category: Synthetic construct]]
	[[Category: Mattos, C]]		[[Category: Clark AC]]
	[[Category: Schipper~~, J L~~]]		[[Category: Mattos C]]
	[[Category: Swartz~~, P D~~]]		[[Category: Schipper JL]]
	[[Category: Walters, J]]		[[Category: Swartz PD]]
	~~[[Category: Allosteric inhibition]]~~		[[Category: Walters J]]
	~~[[Category: Apoptosis]]~~
	~~[[Category: Caspase]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Protein ensemble~~]]

OCA at 08:04, 15 November 2017

2017-11-15T08:04:18Z

← Older revision		Revision as of 08:04, 15 November 2017
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	</div>		</div>
	<div class="pdbe-citations 4ehh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ehh" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Caspase\|Caspase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:25, 5 August 2016

2016-08-05T02:25:33Z

← Older revision		Revision as of 02:25, 5 August 2016
Line 1:		Line 1:

	==Allosteric Modulation of Caspase-3 through Mutagenesis==		==Allosteric Modulation of Caspase-3 through Mutagenesis==
	<StructureSection load='4ehh' size='340' side='right' caption='[[4ehh]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4ehh' size='340' side='right' caption='[[4ehh]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHH FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [http://www.ebi.ac.uk/pdbsum/4ehh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [http://pdbe.org/4ehh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [http://www.ebi.ac.uk/pdbsum/4ehh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ehh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Caspase-3]]		[[Category: Caspase-3]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Clark, A C]]		[[Category: Clark, A C]]
	[[Category: Mattos, C]]		[[Category: Mattos, C]]

OCA at 15:05, 25 December 2014

2014-12-25T15:05:44Z

← Older revision		Revision as of 15:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [http://www.ebi.ac.uk/pdbsum/4ehh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [http://www.ebi.ac.uk/pdbsum/4ehh PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Caspase-3]]		[[Category: Caspase-3]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clark, A C.]]		[[Category: Clark, A C]]
	[[Category: Mattos, C.]]		[[Category: Mattos, C]]
	[[Category: Schipper, J L.]]		[[Category: Schipper, J L]]
	[[Category: Swartz, P D.]]		[[Category: Swartz, P D]]
	[[Category: Walters, J.]]		[[Category: Walters, J]]
	[[Category: Allosteric inhibition]]		[[Category: Allosteric inhibition]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 08:32, 5 June 2014

2014-06-05T08:32:37Z

← Older revision		Revision as of 08:32, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ehh~~.~~png~~\|~~left~~\|~~200px~~]]		==Allosteric Modulation of Caspase-3 through Mutagenesis==
			<StructureSection load='4ehh' size='340' side='right' caption='[[4ehh]], [[Resolution\|resolution]] 1.78Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHH FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eha\|4eha]], [[4ehd\|4ehd]], [[4ehf\|4ehf]], [[4ehk\|4ehk]], [[4ehl\|4ehl]], [[4ehn\|4ehn]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehh RCSB], [http://www.ebi.ac.uk/pdbsum/4ehh PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A mutation in the allosteric site of the caspase-3 dimer interface of V266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site. Mutations were coupled to H266 at two sites in the interface, E124A and Y197C. We present data from X-ray crystallography, enzymatic activity and molecular dynamics simulations for seven proteins, consisting of single, double, and triple mutants. The data demonstrate that considering allosteric inhibition of caspase-3 as a shift between discrete "off-state" or "on-state" conformations is insufficient. While H266 is accommodated in the interface, the structural defects are propagated to the active site through a helix on the protein surface. A more comprehensive view of allosteric regulation of caspase-3 requires the representation of an ensemble of inactive states and shows that subtle structural changes lead to the population of the inactive ensemble.

	~~{{STRUCTURE_4ehh\| PDB=4ehh \| SCENE= }}~~		Allosteric Modulation of Caspase-3 through Mutagenesis.,Walters J, Schipper JL, Swartz P, Mattos C, Clark AC Biosci Rep. 2012 May 18. PMID:22607239<ref>PMID:22607239</ref>

	~~===Allosteric Modulation~~ of ~~Caspase-3 through Mutagenesis===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_22607239}}~~		==See Also==
			*[[Caspase\|Caspase]]
	==~~About this Structure~~==		== References ==
	[[~~4ehh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHH OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:022607239<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Caspase-3]]		[[Category: Caspase-3]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 04:37, 18 July 2012

2012-07-18T04:37:13Z

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	[[Image:4ehh.~~jpg~~\|left\|200px]]		[[Image:4ehh.png\|left\|200px]]

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	{{STRUCTURE_4ehh\| PDB=4ehh \| SCENE= }}		{{STRUCTURE_4ehh\| PDB=4ehh \| SCENE= }}

	===Allosteric Modulation of Caspase-3 through Mutagenesis===		===Allosteric Modulation of Caspase-3 through Mutagenesis===


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OCA at 07:44, 6 June 2012

2012-06-06T07:44:06Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ehh.jpg|left|200px]]
-The entry 4ehh is ON HOLD  until Paper Publication
+<!--
-Authors: Walters, J., Schipper, J.L., Swartz. P.D., Mattos, C., Clark, A.C.
+===Allosteric Modulation of Caspase-3 through Mutagenesis===
-Description: Allosteric Modulation of Caspase-3 through Mutagenesis

OCA at 18:55, 2 May 2012

2012-05-02T18:55:20Z

← Older revision		Revision as of 18:55, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ehh is ON HOLD		The entry 4ehh is ON HOLD until Paper Publication

	Authors: Walters, J., Schipper, J.L., Swartz. P.D., Mattos, C., Clark, A.C.		Authors: Walters, J., Schipper, J.L., Swartz. P.D., Mattos, C., Clark, A.C.

	Description: Allosteric Modulation of Caspase-3 through Mutagenesis		Description: Allosteric Modulation of Caspase-3 through Mutagenesis

OCA: Protected "4ehh" [edit=sysop:move=sysop]

2012-04-11T06:43:19Z

Protected "4ehh" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:43, 11 April 2012
(No difference)