4eig - Revision history

OCA at 10:48, 6 November 2024

2024-11-06T10:48:23Z

← Older revision		Revision as of 10:48, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIG FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [https://pdbe.org/4eig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [https://www.ebi.ac.uk/pdbsum/4eig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eig ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [https://pdbe.org/4eig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [https://www.ebi.ac.uk/pdbsum/4eig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eig ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:12, 28 September 2022

2022-09-28T07:12:45Z

← Older revision		Revision as of 07:12, 28 September 2022
Line 1:		Line 1:

	==CA1698 camel antibody fragment in complex with DHFR==		==CA1698 camel antibody fragment in complex with DHFR==
	<StructureSection load='4eig' size='340' side='right' caption='[[4eig]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4eig' size='340' side='right'caption='[[4eig]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIG FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eiz\|4eiz]], [[4ej1\|4ej1]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [https://pdbe.org/4eig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [https://www.ebi.ac.uk/pdbsum/4eig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eig ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [~~http~~://pdbe.org/4eig PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eig PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eig ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
	*[[3D structures of antibody\|3D structures of antibody]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
			*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Camelus glama~~]]		[[Category: Escherichia coli K-12]]
	[[Category: ~~Dihydrofolate reductase~~]]		[[Category: Lama glama]]
	[[Category: ~~Ecoli~~]]		[[Category: Large Structures]]
	[[Category: Oyen, D]]		[[Category: Oyen D]]
	[[Category: Srinivasan, V]]		[[Category: Srinivasan V]]
	~~[[Category: Nadp binding]]~~
	~~[[Category: Oxidoreductase-immune system complex~~]]

OCA at 08:04, 15 November 2017

2017-11-15T08:04:51Z

← Older revision		Revision as of 08:04, 15 November 2017
Line 22:		Line 22:

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	*[[3D structures of antibody\|3D structures of antibody]]		*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==

OCA at 09:36, 5 August 2016

2016-08-05T09:36:48Z

← Older revision		Revision as of 09:36, 5 August 2016
Line 1:		Line 1:

	==CA1698 camel antibody fragment in complex with DHFR==		==CA1698 camel antibody fragment in complex with DHFR==
	<StructureSection load='4eig' size='340' side='right' caption='[[4eig]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4eig' size='340' side='right' caption='[[4eig]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~] and [http://en.wikipedia.org/wiki/~~Lama_glama Lama glama~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eiz\|4eiz]], [[4ej1\|4ej1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eiz\|4eiz]], [[4ej1\|4ej1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [http://www.ebi.ac.uk/pdbsum/4eig PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [http://pdbe.org/4eig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [http://www.ebi.ac.uk/pdbsum/4eig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eig ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eig" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
			*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Camelus glama]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: ~~Escherichia coli k-12]]~~		[[Category: Ecoli]]
	~~[[Category: Lama glama~~]]
	[[Category: Oyen, D]]		[[Category: Oyen, D]]
	[[Category: Srinivasan, V]]		[[Category: Srinivasan, V]]
	[[Category: Nadp binding]]		[[Category: Nadp binding]]
	[[Category: Oxidoreductase-immune system complex]]		[[Category: Oxidoreductase-immune system complex]]

OCA at 17:43, 25 December 2014

2014-12-25T17:43:20Z

← Older revision		Revision as of 17:43, 25 December 2014
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	~~{{STRUCTURE_4eig~~\| ~~PDB~~=4eig \| ~~SCENE~~= }}		==CA1698 camel antibody fragment in complex with DHFR==
	===~~CA1698 camel antibody fragment~~ in ~~complex with DHFR~~===		<StructureSection load='4eig' size='340' side='right' caption='[[4eig]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_23911607}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIG FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eiz\|4eiz]], [[4ej1\|4ej1]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eig RCSB], [http://www.ebi.ac.uk/pdbsum/4eig PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Although allosteric effector antibodies are used widely as modulators of receptors and enzymes, experimental analysis of their mechanism remains highly challenging. Here, we investigate the molecular mechanisms of allosteric and non-allosteric effector antibodies in an experimentally tractable system, consisting of single-domain antibodies (nanobodies) that target the model enzyme dihydrofolate reductase (DHFR) from Escherichia coli. A panel of thirty-five nanobodies was isolated using several strategies to increase nanobody diversity. The nanobodies exhibit a variety of effector properties, including partial inhibition, strong inhibition and stimulation of DHFR activity. Despite these diverse effector properties, chemical shift perturbation NMR epitope mapping identified only two epitope regions: epitope alpha is a new allosteric site that is over 10A from the active site, while epitope beta is located in the region of the Met20 loop. The structural basis for DHFR allosteric inhibition or activation upon nanobody binding to the alpha epitope was examined by solving the crystal structures of DHFR in complex with Nb113 (an allosteric inhibitor) and Nb179 (an allosteric activator). The structures suggest roles for conformational constraint and altered protein dynamics, but not epitope distortion, in the observed allosteric effects. The crystal structure of a beta epitope region binder (ca1698) in complex with DHFR is also reported. Although CDR3 of ca1698 occupies the substrate binding site, ca1698 displays linear mixed inhibition kinetics instead of simple competitive inhibition kinetics. Two mechanisms are proposed to account for this apparent anomaly. Evidence for structural convergence of ca1698 and Nb216 during affinity maturation is also presented.

	~~==Function==~~		Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.,Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN Biochim Biophys Acta. 2013 Jul 31. pii: S1570-9639(13)00282-3. doi:, 10.1016/j.bbapap.2013.07.010. PMID:23911607<ref>PMID:23911607</ref>
	~~[[http~~:/~~/www~~.~~uniprot~~.~~org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism~~. ~~Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4eig]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en~~.~~wikipedia~~.~~org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=4EIG OCA].~~		</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023911607</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Oyen, D.]]		[[Category: Oyen, D]]
	[[Category: Srinivasan, V.]]		[[Category: Srinivasan, V]]
	[[Category: Nadp binding]]		[[Category: Nadp binding]]
	[[Category: Oxidoreductase-immune system complex]]		[[Category: Oxidoreductase-immune system complex]]

OCA at 09:03, 4 September 2013

2013-09-04T09:03:14Z

← Older revision		Revision as of 09:03, 4 September 2013
Line 10:		Line 10:

	==See Also==		==See Also==
			*[[Antibody\|Antibody]]
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]

OCA at 06:31, 14 August 2013

2013-08-14T06:31:47Z

← Older revision		Revision as of 06:31, 14 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4eig\| PDB=4eig \| SCENE= }}		{{STRUCTURE_4eig\| PDB=4eig \| SCENE= }}
	===CA1698 camel antibody fragment in complex with DHFR===		===CA1698 camel antibody fragment in complex with DHFR===
			{{ABSTRACT_PUBMED_23911607}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA].		[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA].

			==See Also==
			*[[Dihydrofolate reductase\|Dihydrofolate reductase]]

			==Reference==
			<ref group="xtra">PMID:023911607</ref><references group="xtra"/><references/>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]

OCA at 11:27, 24 April 2013

2013-04-24T11:27:21Z

← Older revision		Revision as of 11:27, 24 April 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4eig\| PDB=4eig \| SCENE= }}
			===CA1698 camel antibody fragment in complex with DHFR===

	~~The entry 4eig is ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

	~~Authors~~: Oyen, D., Srinivasan, V.		==About this Structure==
			[[4eig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIG OCA].
	~~Description~~: ~~CA1698 camel antibody fragment in~~ complex ~~with DHFR~~		[[Category: Dihydrofolate reductase]]
			[[Category: Escherichia coli k-12]]
			[[Category: Lama glama]]
			[[Category: Oyen, D.]]
			[[Category: Srinivasan, V.]]
			[[Category: Nadp binding]]
			[[Category: Oxidoreductase-immune system complex]]

OCA at 05:26, 30 May 2012

2012-05-30T05:26:37Z

← Older revision		Revision as of 05:26, 30 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eig is ON HOLD		The entry 4eig is ON HOLD until Paper Publication

	Authors: Oyen, D., Srinivasan, V.		Authors: Oyen, D., Srinivasan, V.

	Description: CA1698 camel antibody fragment in complex with DHFR		Description: CA1698 camel antibody fragment in complex with DHFR

OCA at 07:31, 18 April 2012

2012-04-18T07:31:59Z

← Older revision		Revision as of 07:31, 18 April 2012
Line 5:		Line 5:
	Authors: Oyen, D., Srinivasan, V.		Authors: Oyen, D., Srinivasan, V.

	Description: ~~ca1698~~ camel antibody fragment in complex with DHFR		Description: CA1698 camel antibody fragment in complex with DHFR