4ej7 - Revision history

OCA at 07:13, 28 September 2022

2022-09-28T07:13:42Z

← Older revision		Revision as of 07:13, 28 September 2022
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	==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound==		==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound==
	<StructureSection load='4ej7' size='340' side='right' caption='[[4ej7]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4ej7' size='340' side='right'caption='[[4ej7]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ej7]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aciby Aciby~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EJ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ej7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, ~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ej7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej7 OCA], [https://pdbe.org/4ej7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ej7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ej7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej7 ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4feu\|4feu]], [[4gkh\|4gkh]], [[4gki\|4gki]], [[4few\|4few]], [[4fev\|4fev]]~~, ~~[[4fex\|4fex]]~~<~~/td></tr>~~
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">ABAYE3578, APHA1-IAB~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 ACIBY]~~)~~</td></tr>~~
	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kanamycin_kinase Kanamycin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.95 2.7.1.95] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ej7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej7 OCA], [~~http~~://pdbe.org/4ej7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ej7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ej7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej7 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/B0VD92_ACIBY B0VD92_ACIBY]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Aciby~~]]		[[Category: Acinetobacter baumannii AYE]]
	[[Category: ~~Kanamycin kinase~~]]		[[Category: Large Structures]]
	[[Category: Anderson~~, W F~~]]		[[Category: Anderson WF]]
	[[Category: ~~Structural genomic~~]]		[[Category: Di Leo R]]
	[[Category: Egorova, O]]		[[Category: Egorova O]]
	[[Category: Evdokimova, E]]		[[Category: Evdokimova E]]
	~~[[Category: Leo, R Di~~]]		[[Category: Minasov G]]
	[[Category: Minasov, G]]		[[Category: Savchenko A]]
	[[Category: Savchenko, A]]		[[Category: Shakya T]]
	[[Category: Shakya, T]]		[[Category: Stogios PJ]]
	[[Category: Stogios~~, P J~~]]		[[Category: Tan K]]
	[[Category: Tan, K]]		[[Category: Wright GD]]
	[[Category: Wright~~, G D]]~~
	~~[[Category: Alpha/beta protein]]~~
	~~[[Category: Aminoglycoside phosphotransferase]]~~
	~~[[Category: Aminoglycoside]]~~
	~~[[Category: Antibiotic resistance]]~~
	~~[[Category: Csgid]]~~
	~~[[Category: Eukaryotic protein kinase-like fold]]~~
	~~[[Category: Gtp]]~~
	~~[[Category: Intracellular]]~~
	~~[[Category: Kanamycin]]~~
	~~[[Category: National institute of allergy and infectious disease]]~~
	~~[[Category: Niaid]]~~
	~~[[Category: Phosphotransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 20:11, 4 August 2016

2016-08-04T20:11:23Z

← Older revision		Revision as of 20:11, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound==		==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound==
	<StructureSection load='4ej7' size='340' side='right' caption='[[4ej7]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4ej7' size='340' side='right' caption='[[4ej7]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acinetobacter_baumannii_aye Acinetobacter baumannii aye~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EJ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciby Aciby]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EJ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4feu\|4feu]], [[4gkh\|4gkh]], [[4gki\|4gki]], [[4few\|4few]], [[4fev\|4fev]], [[4fex\|4fex]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4feu\|4feu]], [[4gkh\|4gkh]], [[4gki\|4gki]], [[4few\|4few]], [[4fev\|4fev]], [[4fex\|4fex]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABAYE3578, APHA1-IAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 ~~Acinetobacter baumannii AYE~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABAYE3578, APHA1-IAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 ACIBY])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kanamycin_kinase Kanamycin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.95 2.7.1.95] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kanamycin_kinase Kanamycin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.95 2.7.1.95] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ej7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ej7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ej7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ej7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej7 OCA], [http://pdbe.org/4ej7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ej7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ej7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ej7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Acinetobacter baumannii aye~~]]		[[Category: Aciby]]
	[[Category: Kanamycin kinase]]		[[Category: Kanamycin kinase]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]

OCA at 10:48, 21 December 2014

2014-12-21T10:48:45Z

← Older revision		Revision as of 10:48, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4ej7\| PDB=4ej7 \| SCENE= }}~~		==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound==
	===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound===		<StructureSection load='4ej7' size='340' side='right' caption='[[4ej7]], [[Resolution\|resolution]] 2.29Å' scene=''>
	~~{{ABSTRACT_PUBMED_23758273}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EJ7 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4feu\|4feu]], [[4gkh\|4gkh]], [[4gki\|4gki]], [[4few\|4few]], [[4fev\|4fev]], [[4fex\|4fex]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABAYE3578, APHA1-IAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 Acinetobacter baumannii AYE])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kanamycin_kinase Kanamycin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.95 2.7.1.95] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ej7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ej7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ej7 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Activity of the aminoglycoside phosphotransferase APH(3')-Ia leads to resistance to aminoglycoside antibiotics in pathogenic Gram-negative bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescuing compromised antibiotics such as aminoglycosides is targeting the enzymes conferring resistance with small molecules. Previously we demonstrated that eukaryotic protein kinase (ePK) inhibitors could inhibit APH enzymes, due to the structural similarity between these two enzyme families. However, limited structural information of enzyme-inhibitor complexes hindered interpretation of the results. As well, cross-reactivity of compounds between APHs and ePKs represents an obstacle to their use as aminoglycoside adjuvants to rescue aminoglycoside antibiotic activity. Here, we structurally and functionally characterize inhibition of APH(3')-Ia by three diverse chemical scaffolds - anthrapyrazolone, 4-anilinoquinazoline and pyrazolopyrimidine (PP) - and reveal distinctions in the binding mode of anthrapyrazolone and PP compounds to APH(3')-Ia versus ePKs. Using this observation, we identify PP-derivatives that select against ePKs, attenuate APH(3')-Ia activity and rescue aminoglycoside antibiotic activity against a resistant E. coli strain. The structures presented here and these inhibition studies provide an important opportunity for structure-based design of compounds to target aminoglycoside phosphotransferases for inhibition, potentially overcoming this form of antibiotic resistance.

	~~==About this~~ Structure==		Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.,Stogios PJ, Spanogiannopoulos P, Evdokimova E, Egorova O, Shakya T, Todorovic N, Capretta A, Wright GD, Savchenko A Biochem J. 2013 Jun 12. PMID:23758273<ref>PMID:23758273</ref>
	~~[[4ej7]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]~~. ~~This structure supersedes the now removed PDB entry [http~~://~~oca.weizmann.ac.il/oca-bin/send-pdb?obs=1~~&~~id=3r78 3r78]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4EJ7 OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023758273</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Acinetobacter baumannii aye]]		[[Category: Acinetobacter baumannii aye]]
	[[Category: Kanamycin kinase]]		[[Category: Kanamycin kinase]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F]]
	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]		[[Category: Structural genomic]]
	[[Category: Egorova, O.]]		[[Category: Egorova, O]]
	[[Category: Evdokimova, E.]]		[[Category: Evdokimova, E]]
	[[Category: Leo, R Di.]]		[[Category: Leo, R Di]]
	[[Category: Minasov, G.]]		[[Category: Minasov, G]]
	[[Category: Savchenko, A.]]		[[Category: Savchenko, A]]
	[[Category: Shakya, T.]]		[[Category: Shakya, T]]
	[[Category: Stogios, P J.]]		[[Category: Stogios, P J]]
	[[Category: Tan, K.]]		[[Category: Tan, K]]
	[[Category: Wright, G D.]]		[[Category: Wright, G D]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Aminoglycoside phosphotransferase]]		[[Category: Aminoglycoside phosphotransferase]]
	[[Category: Aminoglycoside]]		[[Category: Aminoglycoside]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	~~[[Category: Center for structural genomics of infectious disease]]~~
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Eukaryotic protein kinase-like fold]]		[[Category: Eukaryotic protein kinase-like fold]]

OCA at 19:04, 7 August 2013

2013-08-07T19:04:34Z

← Older revision		Revision as of 19:04, 7 August 2013
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].		[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].

			==See Also==
			*[[Phosphotransferase\|Phosphotransferase]]

	==Reference==		==Reference==

OCA at 07:18, 30 June 2013

2013-06-30T07:18:03Z

← Older revision		Revision as of 07:18, 30 June 2013
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	~~[[Image:4ej7.png\|left\|200px]]~~

	{{STRUCTURE_4ej7\| PDB=4ej7 \| SCENE= }}		{{STRUCTURE_4ej7\| PDB=4ej7 \| SCENE= }}

	===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound===		===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound===
			{{ABSTRACT_PUBMED_23758273}}

	==About this Structure==		==About this Structure==
	[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acinetobacter_baumannii~~ Acinetobacter baumannii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].		[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].

	==~~See Also~~==		==Reference==
	*[[Phosphotransferase\|Phosphotransferase]]		<ref group="xtra">PMID:023758273</ref><references group="xtra"/><references/>
	[[Category: Acinetobacter baumannii]]		[[Category: Acinetobacter baumannii aye]]
	[[Category: Kanamycin kinase]]		[[Category: Kanamycin kinase]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 08:15, 20 October 2012

2012-10-20T08:15:21Z

← Older revision		Revision as of 08:15, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[4ej7]] is a 3 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].		[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].

	==See Also==		==See Also==

OCA at 18:56, 25 July 2012

2012-07-25T18:56:24Z

← Older revision		Revision as of 18:56, 25 July 2012
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	[[Image:4ej7.~~jpg~~\|left\|200px]]		[[Image:4ej7.png\|left\|200px]]

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	{{STRUCTURE_4ej7\| PDB=4ej7 \| SCENE= }}		{{STRUCTURE_4ej7\| PDB=4ej7 \| SCENE= }}

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	==About this Structure==		==About this Structure==
	[[4ej7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].		[[4ej7]] is a 3 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r78 3r78]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ7 OCA].

			==See Also==
			*[[Phosphotransferase\|Phosphotransferase]]
	[[Category: Acinetobacter baumannii]]		[[Category: Acinetobacter baumannii]]
	[[Category: Kanamycin kinase]]		[[Category: Kanamycin kinase]]

OCA: Protected "4ej7" [edit=sysop:move=sysop]

2012-04-18T07:47:58Z

Protected "4ej7" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:47, 18 April 2012
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