4eo4 - Revision history

OCA at 11:04, 1 March 2024

2024-03-01T11:04:27Z

← Older revision		Revision as of 11:04, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.87Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [https://pdbe.org/4eo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [https://www.ebi.ac.uk/pdbsum/4eo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eo4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [https://pdbe.org/4eo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [https://www.ebi.ac.uk/pdbsum/4eo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eo4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SYTM_YEAST SYTM_YEAST]]		[https://www.uniprot.org/uniprot/SYTM_YEAST SYTM_YEAST]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Accurate translation of mRNA into protein is a fundamental biological process critical for maintaining normal cellular functions. To ensure translational fidelity, aminoacyl-tRNA synthetases (aaRSs) employ pre-transfer and post-transfer editing activities to hydrolyze misactivated and mischarged amino acids, respectively. Whereas post-transfer editing, which requires either a specialized domain in aaRS or a trans-protein factor, is well described, the mechanism of pre-transfer editing is less understood. Here, we show that yeast mitochondrial threonyl-tRNA synthetase (MST1), which lacks an editing domain, utilizes pre-transfer editing to discriminate against serine. MST1 misactivates serine and edits seryl adenylate (Ser-AMP) in a tRNA-independent manner. MST1 hydrolyzes 80% of misactivated Ser-AMP at a rate 4-fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-AMP into the solution. To understand the mechanism of pre-transfer editing, we solved the crystal structure of MST1 complexed with an analog of Ser-AMP. The binding of the Ser-AMP analog to MST1 induces conformational changes in the aminoacylation active site, and it positions a potential hydrolytic water molecule more favorably for nucleophilic attack. In addition, inhibition results reveal that the Ser-AMP analog binds the active site 100-fold less tightly than the Thr-AMP analog. In conclusion, we propose that the plasticity of the aminoacylation site in MST1 allows binding of Ser-AMP and the appropriate positioning of the hydrolytic water molecule.

	The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.,Ling J, Peterson KM, Simonovic I, Soll D, Simonovic M J Biol Chem. 2012 Aug 17;287(34):28518-25. doi: 10.1074/jbc.M112.372920. Epub, 2012 Jul 6. PMID:22773845<ref>PMID:22773845</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4eo4" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]		*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:20, 28 September 2022

2022-09-28T07:20:21Z

← Older revision		Revision as of 07:20, 28 September 2022
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	==Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate==		==Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate==
	<StructureSection load='4eo4' size='340' side='right' caption='[[4eo4]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4eo4' size='340' side='right'caption='[[4eo4]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ugq\|3ugq]], [[3ugt\|3ugt]], [[3uh0\|3uh0]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [https://pdbe.org/4eo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [https://www.ebi.ac.uk/pdbsum/4eo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eo4 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, YKL194C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [~~http~~://pdbe.org/4eo4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eo4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eo4 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[https://www.uniprot.org/uniprot/SYTM_YEAST SYTM_YEAST]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4eo4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4eo4" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Baker's yeast~~]]		[[Category: Large Structures]]
	[[Category: ~~Threonine--tRNA ligase~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: Ling, J]]		[[Category: Ling J]]
	[[Category: Peterson~~, K M~~]]		[[Category: Peterson KM]]
	[[Category: Simonovic, I]]		[[Category: Simonovic I]]
	[[Category: Simonovic, M]]		[[Category: Simonovic M]]
	[[Category: Soll, D]]		[[Category: Soll D]]
	~~[[Category: Aminoacyl-trna synthetase class ii]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Mitochondria]]~~
	~~[[Category: Threonine trna]]~~
	~~[[Category: Threonyl-trna synthetase~~]]

OCA at 19:35, 11 August 2016

2016-08-11T19:35:00Z

← Older revision		Revision as of 19:35, 11 August 2016
Line 1:		Line 1:

	==Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate==		==Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate==
	<StructureSection load='4eo4' size='340' side='right' caption='[[4eo4]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4eo4' size='340' side='right' caption='[[4eo4]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ugq\|3ugq]], [[3ugt\|3ugt]], [[3uh0\|3uh0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ugq\|3ugq]], [[3ugt\|3ugt]], [[3uh0\|3uh0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, YKL194C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, YKL194C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [http://www.ebi.ac.uk/pdbsum/4eo4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [http://pdbe.org/4eo4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [http://www.ebi.ac.uk/pdbsum/4eo4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eo4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eo4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae s288c~~]]		[[Category: Baker's yeast]]
	[[Category: Threonine--tRNA ligase]]		[[Category: Threonine--tRNA ligase]]
	[[Category: Ling, J]]		[[Category: Ling, J]]

OCA at 12:16, 4 January 2015

2015-01-04T12:16:59Z

← Older revision		Revision as of 12:16, 4 January 2015
Line 1:		Line 1:
	[[~~Image~~:~~4eo4~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate==
			<StructureSection load='4eo4' size='340' side='right' caption='[[4eo4]], [[Resolution\|resolution]] 2.87Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EO4 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ugq\|3ugq]], [[3ugt\|3ugt]], [[3uh0\|3uh0]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, YKL194C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eo4 RCSB], [http://www.ebi.ac.uk/pdbsum/4eo4 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Accurate translation of mRNA into protein is a fundamental biological process critical for maintaining normal cellular functions. To ensure translational fidelity, aminoacyl-tRNA synthetases (aaRSs) employ pre-transfer and post-transfer editing activities to hydrolyze misactivated and mischarged amino acids, respectively. Whereas post-transfer editing, which requires either a specialized domain in aaRS or a trans-protein factor, is well described, the mechanism of pre-transfer editing is less understood. Here, we show that yeast mitochondrial threonyl-tRNA synthetase (MST1), which lacks an editing domain, utilizes pre-transfer editing to discriminate against serine. MST1 misactivates serine and edits seryl adenylate (Ser-AMP) in a tRNA-independent manner. MST1 hydrolyzes 80% of misactivated Ser-AMP at a rate 4-fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-AMP into the solution. To understand the mechanism of pre-transfer editing, we solved the crystal structure of MST1 complexed with an analog of Ser-AMP. The binding of the Ser-AMP analog to MST1 induces conformational changes in the aminoacylation active site, and it positions a potential hydrolytic water molecule more favorably for nucleophilic attack. In addition, inhibition results reveal that the Ser-AMP analog binds the active site 100-fold less tightly than the Thr-AMP analog. In conclusion, we propose that the plasticity of the aminoacylation site in MST1 allows binding of Ser-AMP and the appropriate positioning of the hydrolytic water molecule.

	~~{{STRUCTURE_4eo4\| PDB=4eo4 \| SCENE= }}~~		The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.,Ling J, Peterson KM, Simonovic I, Soll D, Simonovic M J Biol Chem. 2012 Aug 17;287(34):28518-25. doi: 10.1074/jbc.M112.372920. Epub, 2012 Jul 6. PMID:22773845<ref>PMID:22773845</ref>

	~~===Crystal structure~~ of the ~~yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22773845}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[4eo4]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA].~~		</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Threonine--tRNA ligase]]		[[Category: Threonine--tRNA ligase]]
	[[Category: Ling, J.]]		[[Category: Ling, J]]
	[[Category: Peterson, K M.]]		[[Category: Peterson, K M]]
	[[Category: Simonovic, I.]]		[[Category: Simonovic, I]]
	[[Category: Simonovic, M.]]		[[Category: Simonovic, M]]
	[[Category: Soll, D.]]		[[Category: Soll, D]]
	[[Category: Aminoacyl-trna synthetase class ii]]		[[Category: Aminoacyl-trna synthetase class ii]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 07:05, 2 January 2013

2013-01-02T07:05:42Z

← Older revision		Revision as of 07:05, 2 January 2013
Line 1:		Line 1:
	[[Image:4eo4.~~jpg~~\|left\|200px]]		[[Image:4eo4.png\|left\|200px]]

	{{STRUCTURE_4eo4\| PDB=4eo4 \| SCENE= }}		{{STRUCTURE_4eo4\| PDB=4eo4 \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate===		===Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate===

			{{ABSTRACT_PUBMED_22773845}}

	==About this Structure==		==About this Structure==
	[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae~~ Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA].		[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA].
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Threonine--tRNA ligase]]		[[Category: Threonine--tRNA ligase]]
	[[Category: Ling, J.]]		[[Category: Ling, J.]]

OCA at 08:24, 11 July 2012

2012-07-11T08:24:44Z

← Older revision		Revision as of 08:24, 11 July 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4eo4.jpg\|left\|200px]]

	~~The entry~~ 4eo4 ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4eo4\| PDB=4eo4 \| SCENE= }}

	~~Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.~~		===Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate===

	~~Description~~: ~~Crystal structure of the yeast mitochondrial threonyl~~-tRNA synthetase ~~(MST1) in complex with seryl sulfamoyl adenylate~~
			==About this Structure==
			[[4eo4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO4 OCA].
			[[Category: Saccharomyces cerevisiae]]
			[[Category: Threonine--tRNA ligase]]
			[[Category: Ling, J.]]
			[[Category: Peterson, K M.]]
			[[Category: Simonovic, I.]]
			[[Category: Simonovic, M.]]
			[[Category: Soll, D.]]
			[[Category: Aminoacyl-trna synthetase class ii]]
			[[Category: Ligase]]
			[[Category: Mitochondria]]
			[[Category: Threonine trna]]
			[[Category: Threonyl-trna synthetase]]

OCA at 08:49, 16 May 2012

2012-05-16T08:49:05Z

← Older revision		Revision as of 08:49, 16 May 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eo4 is ON HOLD		The entry 4eo4 is ON HOLD until Paper Publication

	Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.		Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.

	Description: Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate		Description: Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate

OCA: Protected "4eo4" [edit=sysop:move=sysop]

2012-04-25T08:55:11Z

Protected "4eo4" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:55, 25 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4eo4 is ON HOLD Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M. Description: Crystal structure of the yeast mitochondrial...

2012-04-25T08:55:10Z

New page: '''Unreleased structure''' The entry 4eo4 is ON HOLD Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M. Description: Crystal structure of the yeast mitochondrial...

New page

'''Unreleased structure'''

The entry 4eo4 is ON HOLD

Authors: Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.

Description: Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate