4eot - Revision history

OCA at 15:06, 14 March 2024

2024-03-14T15:06:13Z

← Older revision		Revision as of 15:06, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.855Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [https://pdbe.org/4eot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [https://www.ebi.ac.uk/pdbsum/4eot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [https://pdbe.org/4eot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [https://www.ebi.ac.uk/pdbsum/4eot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN]] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref>		[https://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	MafA is a proto-oncoprotein and is critical for insulin gene expression in pancreatic beta-cells. Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic helix and an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DNA binding properties: binding a 13 bp consensus site consisting of a core AP1 site (TGACTCA) flanked by TGC sequences and binding DNA stably as monomers. To further characterize maf DNA binding, we determined the structure of a MafA-DNA complex. MafA forms base-specific hydrogen bonds with the flanking G(-5)C(-4) and central C(0)/G(0) bases, but not with the core-TGA bases. However, in vitro binding studies utilizing a pulse-chase electrophoretic mobility shift assay protocol revealed that mutating either the core-TGA or flanking-TGC bases dramatically increases the binding off rate. Comparing the known maf structures, we propose that DNA binding specificity results from positioning the basic helix through unique phosphate contacts. The EHR does not contact DNA directly but stabilizes DNA binding by contacting the basic helix. Collectively, these results suggest a novel multistep DNA binding process involving a conformational change from contacting the core-TGA to contacting the flanking-TGC bases.

	A Novel DNA Binding Mechanism for maf Basic Region-Leucine Zipper Factors Inferred from a MafA-DNA Complex Structure and Binding Specificities.,Lu X, Guanga GP, Wan C, Rose RB Biochemistry. 2012 Nov 20. PMID:23148532<ref>PMID:23148532</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4eot" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==

OCA at 07:21, 28 September 2022

2022-09-28T07:21:07Z

← Older revision		Revision as of 07:21, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of the MafA homodimer bound to the consensus MARE==		==Crystal structure of the MafA homodimer bound to the consensus MARE==
	<StructureSection load='4eot' size='340' side='right' caption='[[4eot]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4eot' size='340' side='right'caption='[[4eot]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EOT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [https://pdbe.org/4eot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [https://www.ebi.ac.uk/pdbsum/4eot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [~~http~~://pdbe.org/4eot PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eot PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN]] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref>		[[https://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN]] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
	*[[Transcriptional activator\|Transcriptional activator]]		*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Guanga, G]]		[[Category: Large Structures]]
	[[Category: Lu, X]]		[[Category: Guanga G]]
	[[Category: Rose~~, R B~~]]		[[Category: Lu X]]
	[[Category: Wan, C]]		[[Category: Rose RB]]
	~~[[Category: Dna binding]]~~		[[Category: Wan C]]
	~~[[Category: Leucine zipper]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Transcription factor]]~~
	~~[[Category: Transcription-dna complex~~]]

OCA at 14:02, 4 August 2016

2016-08-04T14:02:32Z

← Older revision		Revision as of 14:02, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the MafA homodimer bound to the consensus MARE==		==Crystal structure of the MafA homodimer bound to the consensus MARE==
	<StructureSection load='4eot' size='340' side='right' caption='[[4eot]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4eot' size='340' side='right' caption='[[4eot]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [http://www.ebi.ac.uk/pdbsum/4eot PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [http://pdbe.org/4eot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [http://www.ebi.ac.uk/pdbsum/4eot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eot ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eot" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Guanga, G]]		[[Category: Guanga, G]]
	[[Category: Lu, X]]		[[Category: Lu, X]]

OCA at 15:23, 24 December 2014

2014-12-24T15:23:57Z

← Older revision		Revision as of 15:23, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [http://www.ebi.ac.uk/pdbsum/4eot PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [http://www.ebi.ac.uk/pdbsum/4eot PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MAFA_HUMAN MAFA_HUMAN]] Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:12011435</ref> <ref>PMID:12368292</ref> <ref>PMID:15665000</ref> <ref>PMID:15993959</ref> <ref>PMID:18042454</ref> <ref>PMID:19143053</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:18, 9 December 2014

2014-12-09T17:18:24Z

← Older revision		Revision as of 17:18, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4eot~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the MafA homodimer bound to the consensus MARE==
			<StructureSection load='4eot' size='340' side='right' caption='[[4eot]], [[Resolution\|resolution]] 2.85Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOT FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eot RCSB], [http://www.ebi.ac.uk/pdbsum/4eot PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			MafA is a proto-oncoprotein and is critical for insulin gene expression in pancreatic beta-cells. Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic helix and an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DNA binding properties: binding a 13 bp consensus site consisting of a core AP1 site (TGACTCA) flanked by TGC sequences and binding DNA stably as monomers. To further characterize maf DNA binding, we determined the structure of a MafA-DNA complex. MafA forms base-specific hydrogen bonds with the flanking G(-5)C(-4) and central C(0)/G(0) bases, but not with the core-TGA bases. However, in vitro binding studies utilizing a pulse-chase electrophoretic mobility shift assay protocol revealed that mutating either the core-TGA or flanking-TGC bases dramatically increases the binding off rate. Comparing the known maf structures, we propose that DNA binding specificity results from positioning the basic helix through unique phosphate contacts. The EHR does not contact DNA directly but stabilizes DNA binding by contacting the basic helix. Collectively, these results suggest a novel multistep DNA binding process involving a conformational change from contacting the core-TGA to contacting the flanking-TGC bases.

	~~{{STRUCTURE_4eot\| PDB=4eot \| SCENE= }}~~		A Novel DNA Binding Mechanism for maf Basic Region-Leucine Zipper Factors Inferred from a MafA-DNA Complex Structure and Binding Specificities.,Lu X, Guanga GP, Wan C, Rose RB Biochemistry. 2012 Nov 20. PMID:23148532<ref>PMID:23148532</ref>

	~~===Crystal structure~~ of the ~~MafA homodimer bound to the consensus MARE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23148532}}~~		==See Also==
			*[[Transcriptional activator\|Transcriptional activator]]
	==~~About this Structure~~==		== References ==
	[[~~4eot~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guanga, G.]]		[[Category: Guanga, G]]
	[[Category: Lu, X.]]		[[Category: Lu, X]]
	[[Category: Rose, R B.]]		[[Category: Rose, R B]]
	[[Category: Wan, C.]]		[[Category: Wan, C]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]

OCA at 07:16, 2 January 2013

2013-01-02T07:16:19Z

← Older revision		Revision as of 07:16, 2 January 2013
Line 1:		Line 1:
	[[Image:4eot.~~jpg~~\|left\|200px]]		[[Image:4eot.png\|left\|200px]]

	{{STRUCTURE_4eot\| PDB=4eot \| SCENE= }}		{{STRUCTURE_4eot\| PDB=4eot \| SCENE= }}

OCA at 14:26, 28 November 2012

2012-11-28T14:26:45Z

← Older revision		Revision as of 14:26, 28 November 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4eot.jpg\|left\|200px]]

	~~The entry~~ 4eot ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4eot\| PDB=4eot \| SCENE= }}

	~~Authors: Lu, X., Guanga, G., Wan, C., Rose, R.B.~~		===Crystal structure of the MafA homodimer bound to the consensus MARE===

	~~Description~~: ~~Crystal structure of the MafA homodimer bound to the consensus MARE~~		{{ABSTRACT_PUBMED_23148532}}

			==About this Structure==
			[[4eot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOT OCA].
			[[Category: Homo sapiens]]
			[[Category: Guanga, G.]]
			[[Category: Lu, X.]]
			[[Category: Rose, R B.]]
			[[Category: Wan, C.]]
			[[Category: Dna binding]]
			[[Category: Leucine zipper]]
			[[Category: Nucleus]]
			[[Category: Transcription factor]]
			[[Category: Transcription-dna complex]]

OCA at 08:48, 9 May 2012

2012-05-09T08:48:27Z

← Older revision		Revision as of 08:48, 9 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eot is ON HOLD		The entry 4eot is ON HOLD until Paper Publication

	Authors: Lu, X., Guanga, G., Wan, C., Rose, R.B.		Authors: Lu, X., Guanga, G., Wan, C., Rose, R.B.

	Description: Crystal structure of the MafA homodimer bound to the consensus MARE		Description: Crystal structure of the MafA homodimer bound to the consensus MARE

OCA at 18:56, 2 May 2012

2012-05-02T18:56:48Z

← Older revision		Revision as of 18:56, 2 May 2012
Line 3:		Line 3:
	The entry 4eot is ON HOLD		The entry 4eot is ON HOLD

	Authors: Lu, X., Guanga, G., Wan, C., Rose, R. B.		Authors: Lu, X., Guanga, G., Wan, C., Rose, R.B.

	Description: Crystal structure of the MafA homodimer bound to the consensus MARE		Description: Crystal structure of the MafA homodimer bound to the consensus MARE

OCA: Protected "4eot" [edit=sysop:move=sysop]

2012-04-25T08:55:49Z

Protected "4eot" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:55, 25 April 2012
(No difference)