4eup - Revision history

OCA at 15:09, 14 March 2024

2024-03-14T15:09:41Z

← Older revision		Revision as of 15:09, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUP FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [https://pdbe.org/4eup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [https://www.ebi.ac.uk/pdbsum/4eup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.88Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [https://pdbe.org/4eup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [https://www.ebi.ac.uk/pdbsum/4eup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
			*[[MHC 3D structures\|MHC 3D structures]]
			*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:17, 7 October 2022

2022-10-07T04:17:27Z

← Older revision		Revision as of 04:17, 7 October 2022
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	==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==		==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==
	<StructureSection load='4eup' size='340' side='right' caption='[[4eup]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4eup' size='340' side='right'caption='[[4eup]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUP FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4euq\|4euq]], [[4eur\|4eur]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [https://pdbe.org/4eup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [https://www.ebi.ac.uk/pdbsum/4eup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [~~http~~://pdbe.org/4eup PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eup PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
	[~~[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http~~://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN]] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref> ~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~		[https://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref>

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Baker, B M~~]]		[[Category: Large Structures]]
	[[Category: ~~Hossain, M~~]]		[[Category: Baker BM]]
	[[Category: ~~Cancer]]~~		[[Category: Hossain M]]
	~~[[Category: Cross-reactivity]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Melanoma]]~~
	~~[[Category: Mhc class i]]~~
	~~[[Category: Nonapeptide~~]]

OCA at 19:42, 4 August 2016

2016-08-04T19:42:15Z

← Older revision		Revision as of 19:42, 4 August 2016
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	==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==		==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==
	<StructureSection load='4eup' size='340' side='right' caption='[[4eup]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4eup' size='340' side='right' caption='[[4eup]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EUP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4euq\|4euq]], [[4eur\|4eur]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4euq\|4euq]], [[4eur\|4eur]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [http://www.ebi.ac.uk/pdbsum/4eup PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [http://pdbe.org/4eup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [http://www.ebi.ac.uk/pdbsum/4eup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Baker, B M]]		[[Category: Baker, B M]]
	[[Category: Hossain, M]]		[[Category: Hossain, M]]

OCA at 11:30, 21 December 2014

2014-12-21T11:30:54Z

← Older revision		Revision as of 11:30, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4eup\| PDB=4eup \| SCENE= }}~~		==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==
	===The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide===		<StructureSection load='4eup' size='340' side='right' caption='[[4eup]], [[Resolution\|resolution]] 2.88Å' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EUP FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4euq\|4euq]], [[4eur\|4eur]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [http://www.ebi.ac.uk/pdbsum/4eup PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>		[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
			== Function ==
	==Function==
	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN]] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN]] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==~~About this Structure~~==		==See Also==
	[[~~4eup~~]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA].		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
			== References ==
	==~~Reference~~==		<references/>
	<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, B M.]]		[[Category: Baker, B M]]
	[[Category: Hossain, M.]]		[[Category: Hossain, M]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Cross-reactivity]]		[[Category: Cross-reactivity]]

OCA at 07:47, 2 May 2013

2013-05-02T07:47:26Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4eup|  PDB=4eup  |  SCENE=  }}
-The entry 4eup is ON HOLD  until Paper Publication
+==Disease==
-Authors: Hossain, M., Baker, B.M.
+==Function==
-Description: The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide
+==About this Structure==

OCA at 07:21, 20 June 2012

2012-06-20T07:21:29Z

← Older revision		Revision as of 07:21, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4eup is ON HOLD		The entry 4eup is ON HOLD until Paper Publication

	Authors: Hossain, M., Baker, B.M.		Authors: Hossain, M., Baker, B.M.

	Description: The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide		Description: The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide

OCA at 08:50, 16 May 2012

2012-05-16T08:50:41Z

← Older revision		Revision as of 08:50, 16 May 2012
Line 5:		Line 5:
	Authors: Hossain, M., Baker, B.M.		Authors: Hossain, M., Baker, B.M.

	Description: ~~THE COMPLEX BETWEEN~~ TCR JKF6 ~~AND HUMAN CLASS~~ I MHC HLA-A2 ~~PRESENTING THE~~ MART-1(27-35)(A27L) ~~PEPTIDE~~		Description: The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide

OCA: Protected "4eup" [edit=sysop:move=sysop]

2012-05-02T19:00:11Z

Protected "4eup" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:00, 2 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4eup is ON HOLD Authors: Hossain, M., Baker, B.M. Description: THE COMPLEX BETWEEN TCR JKF6 AND HUMAN CLASS I MHC HLA-A2 PRESENTING THE MART-1(27-3...

2012-05-02T19:00:10Z

New page: '''Unreleased structure''' The entry 4eup is ON HOLD Authors: Hossain, M., Baker, B.M. Description: THE COMPLEX BETWEEN TCR JKF6 AND HUMAN CLASS I MHC HLA-A2 PRESENTING THE MART-1(27-3...

New page

'''Unreleased structure'''

The entry 4eup is ON HOLD

Authors: Hossain, M., Baker, B.M.

Description: THE COMPLEX BETWEEN TCR JKF6 AND HUMAN CLASS I MHC HLA-A2 PRESENTING THE MART-1(27-35)(A27L) PEPTIDE