4eyr - Revision history

OCA at 11:06, 1 March 2024

2024-03-01T11:06:49Z

← Older revision		Revision as of 11:06, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [https://pdbe.org/4eyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [https://www.ebi.ac.uk/pdbsum/4eyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [https://pdbe.org/4eyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [https://www.ebi.ac.uk/pdbsum/4eyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q000H7_9HIV1 Q000H7_9HIV1]		[https://www.uniprot.org/uniprot/Q000H7_9HIV1 Q000H7_9HIV1]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Ritonavir (RTV) is a first generation HIV-1 protease inhibitor with rapidly emerging drug resistance. Mutations at residues 46, 54, 82 and 84 render the HIV-1 protease drug resistant against RTV. We report the crystal structure of multi-drug resistant (MDR) 769 HIV-1 protease (carrying resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84 and 90) complexed with RTV and the in vitro enzymatic IC(50) of RTV against MDR HIV-1 protease. The structural and functional studies demonstrate significant drug resistance of MDR HIV-1 protease against RTV, arising from reduced hydrogen bonds and Van der Waals interactions between RTV and MDR HIV-1 protease.

	Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.,Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC Biochem Biophys Res Commun. 2013 Jan 8. pii: S0006-291X(13)00021-1. doi:, 10.1016/j.bbrc.2012.12.127. PMID:23313846<ref>PMID:23313846</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4eyr" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]		*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:23, 7 October 2022

2022-10-07T04:23:20Z

← Older revision		Revision as of 04:23, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir==		==Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir==
	<StructureSection load='4eyr' size='340' side='right' caption='[[4eyr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4eyr' size='340' side='right'caption='[[4eyr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tw7\|1tw7]], [[3oq7\|3oq7]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [https://pdbe.org/4eyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [https://www.ebi.ac.uk/pdbsum/4eyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyr ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [~~http~~://pdbe.org/4eyr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eyr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyr ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q000H7_9HIV1 Q000H7_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
	*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]		*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Brunzelle, J S~~]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: ~~Kovari, I A~~]]		[[Category: Large Structures]]
	[[Category: ~~Kovari, L C~~]]		[[Category: Brunzelle JS]]
	[[Category: ~~Liu, Z~~]]		[[Category: Kovari IA]]
	[[Category: ~~Wang, Y~~]]		[[Category: Kovari LC]]
	[[Category: ~~Yedidi, R S~~]]		[[Category: Liu Z]]
	[[Category: ~~Hydrolase-hydrolase inhibitor complex~~]]		[[Category: Wang Y]]
	[[Category: ~~Protease~~]]		[[Category: Yedidi RS]]

OCA at 05:45, 27 June 2018

2018-06-27T05:45:57Z

← Older revision		Revision as of 05:45, 27 June 2018
Line 20:		Line 20:

	==See Also==		==See Also==
	*[[~~Virus~~ protease\|~~Virus~~ protease]]		*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:54, 11 December 2016

2016-12-11T02:54:22Z

← Older revision		Revision as of 02:54, 11 December 2016
Line 1:		Line 1:

	==Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir==		==Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir==
	<StructureSection load='4eyr' size='340' side='right' caption='[[4eyr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4eyr' size='340' side='right' caption='[[4eyr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EYR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tw7\|1tw7]], [[3oq7\|3oq7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tw7\|1tw7]], [[3oq7\|3oq7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 ~~Human immunodeficiency virus 1~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [http://www.ebi.ac.uk/pdbsum/4eyr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [http://pdbe.org/4eyr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [http://www.ebi.ac.uk/pdbsum/4eyr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eyr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human immunodeficiency virus 1]]~~
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
	[[Category: Kovari, I A]]		[[Category: Kovari, I A]]

OCA at 17:03, 9 December 2014

2014-12-09T17:03:46Z

← Older revision		Revision as of 17:03, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4eyr~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir==
			<StructureSection load='4eyr' size='340' side='right' caption='[[4eyr]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EYR FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tw7\|1tw7]], [[3oq7\|3oq7]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eyr RCSB], [http://www.ebi.ac.uk/pdbsum/4eyr PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Ritonavir (RTV) is a first generation HIV-1 protease inhibitor with rapidly emerging drug resistance. Mutations at residues 46, 54, 82 and 84 render the HIV-1 protease drug resistant against RTV. We report the crystal structure of multi-drug resistant (MDR) 769 HIV-1 protease (carrying resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84 and 90) complexed with RTV and the in vitro enzymatic IC(50) of RTV against MDR HIV-1 protease. The structural and functional studies demonstrate significant drug resistance of MDR HIV-1 protease against RTV, arising from reduced hydrogen bonds and Van der Waals interactions between RTV and MDR HIV-1 protease.

	~~{{STRUCTURE_4eyr\| PDB=4eyr \| SCENE= }}~~		Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.,Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC Biochem Biophys Res Commun. 2013 Jan 8. pii: S0006-291X(13)00021-1. doi:, 10.1016/j.bbrc.2012.12.127. PMID:23313846<ref>PMID:23313846</ref>

	~~===Crystal structure~~ of ~~multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23313846}}~~		==See Also==
			*[[Virus protease\|Virus protease]]
	==~~About this Structure~~==		== References ==
	[[~~4eyr~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S]]
	[[Category: Kovari, I A.]]		[[Category: Kovari, I A]]
	[[Category: Kovari, L C.]]		[[Category: Kovari, L C]]
	[[Category: Liu, Z.]]		[[Category: Liu, Z]]
	[[Category: Wang, Y.]]		[[Category: Wang, Y]]
	[[Category: Yedidi, R S.]]		[[Category: Yedidi, R S]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 13:55, 27 February 2013

2013-02-27T13:55:11Z

← Older revision		Revision as of 13:55, 27 February 2013
Line 1:		Line 1:
	[[Image:4eyr.~~jpg~~\|left\|200px]]		[[Image:4eyr.png\|left\|200px]]

	{{STRUCTURE_4eyr\| PDB=4eyr \| SCENE= }}		{{STRUCTURE_4eyr\| PDB=4eyr \| SCENE= }}

OCA at 12:32, 30 January 2013

2013-01-30T12:32:09Z

← Older revision		Revision as of 12:32, 30 January 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4eyr.jpg\|left\|200px]]

	~~The entry~~ 4eyr ~~is ON HOLD~~		{{STRUCTURE_4eyr\| PDB=4eyr \| SCENE= }}

	~~Authors: Liu, Z., Yedidi, R.S., Wang, Y., Brunzelle, J.S., Kovari, I.A., Kovari, L.C.~~		===Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir===

	~~Description~~: ~~Crystal structure of multidrug~~-~~resistant clinical isolate 769 HIV~~-~~1 protease in~~ complex ~~with ritonavir~~		{{ABSTRACT_PUBMED_23313846}}

			==About this Structure==
			[[4eyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYR OCA].
			[[Category: Human immunodeficiency virus 1]]
			[[Category: Brunzelle, J S.]]
			[[Category: Kovari, I A.]]
			[[Category: Kovari, L C.]]
			[[Category: Liu, Z.]]
			[[Category: Wang, Y.]]
			[[Category: Yedidi, R S.]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
			[[Category: Protease]]

OCA: Protected "4eyr" [edit=sysop:move=sysop]

2012-05-09T08:54:08Z

Protected "4eyr" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:54, 9 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4eyr is ON HOLD Authors: Liu, Z., Yedidi, R.S., Wang, Y., Brunzelle, J.S., Kovari, I.A., Kovari, L.C. Description: Crystal structure of multidrug-r...

2012-05-09T08:54:05Z

New page: '''Unreleased structure''' The entry 4eyr is ON HOLD Authors: Liu, Z., Yedidi, R.S., Wang, Y., Brunzelle, J.S., Kovari, I.A., Kovari, L.C. Description: Crystal structure of multidrug-r...

New page

'''Unreleased structure'''

The entry 4eyr is ON HOLD

Authors: Liu, Z., Yedidi, R.S., Wang, Y., Brunzelle, J.S., Kovari, I.A., Kovari, L.C.

Description: Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir