4eza - Revision history

OCA at 11:07, 1 March 2024

2024-03-01T11:07:00Z

← Older revision		Revision as of 11:07, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [https://pdbe.org/4eza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [https://www.ebi.ac.uk/pdbsum/4eza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [https://pdbe.org/4eza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [https://www.ebi.ac.uk/pdbsum/4eza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.		[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. We describe here the lipid preferences and crystal structure of a new class of PI binding module exemplified by select IQGAPs (IQ motif containing GTPase activating proteins) known to co-ordinate cellular signalling events and cytoskeletal dynamics. This module is defined by a C-terminal 105-107 amino acid region of which that from IQGAP1 and 2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)). The binding affinity for PtdInsP(3), together with other, secondary target-recognition characteristics, are comparable to those of the pleckstrin homology (PH) domain of cytohesin-3 (general receptor for phosphoinositides 1), an established PtdInsP(3) effector protein. Importantly, the IQGAP1 C-terminal domain and the cytohesin-3 PH domain, each tagged with enhanced green fluorescent protein, both re-localized from the cytosol to the cell periphery following the activation of PI 3-kinase in Swiss 3T3 fibroblasts, consistent with their common, selective recognition of endogenous 3-PI(s). The crystal structure of the C-terminal IQGAP2 PI binding module reveals unexpected topological similarity to an integral fold of C2 domains, including a putative basic binding pocket. We propose that this module integrates select IQGAP proteins with PI 3-kinase signalling and constitutes a novel, atypical phosphoinositide (aPI) binding domain that may represent the first of a larger group, each perhaps structurally unique but collectively dissimilar from the known PI recognition modules.

	IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.,Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH J Biol Chem. 2012 Apr 5. PMID:22493426<ref>PMID:22493426</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4eza" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:24, 7 October 2022

2022-10-07T04:24:02Z

← Older revision		Revision as of 04:24, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==		==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==
	<StructureSection load='4eza' size='340' side='right' caption='[[4eza]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4eza' size='340' side='right'caption='[[4eza]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [https://pdbe.org/4eza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [https://www.ebi.ac.uk/pdbsum/4eza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [~~http~~://pdbe.org/4eza PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eza PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN]] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.		[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Aalten, D M.F Van~~]]		[[Category: Large Structures]]
	[[Category: Agacan, M]]		[[Category: Agacan M]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Arrowsmith CH]]
	[[Category: Batty~~, I H~~]]		[[Category: Batty IH]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev A]]
	[[Category: Bountra, C]]		[[Category: Bountra C]]
	[[Category: Crombet, L]]		[[Category: Crombet L]]
	[[Category: Dixon~~, M J~~]]		[[Category: Dixon MJ]]
	[[Category: Downes~~, C P~~]]		[[Category: Downes CP]]
	[[Category: Edwards~~, A M~~]]		[[Category: Edwards AM]]
	[[Category: Gray, A]]		[[Category: Gray A]]
	[[Category: Leslie~~, N R~~]]		[[Category: Leslie NR]]
	[[Category: Nedyalkova, L]]		[[Category: Nedyalkova L]]
	[[Category: Park, H]]		[[Category: Park H]]
	~~[[Category: Structural genomic~~]]		[[Category: Schenning M]]
	[[Category: Schenning, M]]		[[Category: Tempel W]]
	[[Category: Tempel, W]]		[[Category: Tong Y]]
	[[Category: Tong, Y]]		[[Category: Van Aalten DMF]]
	[[Category: ~~Weigelt, J~~]]		[[Category: Weigelt J]]
	[[Category: ~~Zhong, N~~]]		[[Category: Zhong N]]
	[[Category: ~~Gap]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Signaling protein~~]]

OCA at 11:39, 4 August 2016

2016-08-04T11:39:33Z

← Older revision		Revision as of 11:39, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==		==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==
	<StructureSection load='4eza' size='340' side='right' caption='[[4eza]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4eza' size='340' side='right' caption='[[4eza]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [http://www.ebi.ac.uk/pdbsum/4eza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [http://pdbe.org/4eza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [http://www.ebi.ac.uk/pdbsum/4eza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4eza" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Aalten, D M.F Van]]		[[Category: Aalten, D M.F Van]]
	[[Category: Agacan, M]]		[[Category: Agacan, M]]

OCA at 14:01, 24 December 2014

2014-12-24T14:01:24Z

← Older revision		Revision as of 14:01, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [http://www.ebi.ac.uk/pdbsum/4eza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [http://www.ebi.ac.uk/pdbsum/4eza PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN]] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aalten, D M.F Van.]]		[[Category: Aalten, D M.F Van]]
	[[Category: Agacan, M.]]		[[Category: Agacan, M]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Batty, I H.]]		[[Category: Batty, I H]]
	[[Category: Bochkarev, A.]]		[[Category: Bochkarev, A]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Crombet, L.]]		[[Category: Crombet, L]]
	[[Category: Dixon, M J.]]		[[Category: Dixon, M J]]
	[[Category: Downes, C P.]]		[[Category: Downes, C P]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Gray, A.]]		[[Category: Gray, A]]
	[[Category: Leslie, N R.]]		[[Category: Leslie, N R]]
	[[Category: Nedyalkova, L.]]		[[Category: Nedyalkova, L]]
	[[Category: Park, H.]]		[[Category: Park, H]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Schenning, M.]]		[[Category: Schenning, M]]
	[[Category: Tempel, W.]]		[[Category: Tempel, W]]
	[[Category: Tong, Y.]]		[[Category: Tong, Y]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Zhong, N.]]		[[Category: Zhong, N]]
	[[Category: Gap]]		[[Category: Gap]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	~~[[Category: Structural genomics consortium]]~~

OCA at 08:11, 5 June 2014

2014-06-05T08:11:41Z

← Older revision		Revision as of 08:11, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:4eza.~~png\|left\|200px~~]]		==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==
			<StructureSection load='4eza' size='340' side='right' caption='[[4eza]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [http://www.ebi.ac.uk/pdbsum/4eza PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. We describe here the lipid preferences and crystal structure of a new class of PI binding module exemplified by select IQGAPs (IQ motif containing GTPase activating proteins) known to co-ordinate cellular signalling events and cytoskeletal dynamics. This module is defined by a C-terminal 105-107 amino acid region of which that from IQGAP1 and 2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)). The binding affinity for PtdInsP(3), together with other, secondary target-recognition characteristics, are comparable to those of the pleckstrin homology (PH) domain of cytohesin-3 (general receptor for phosphoinositides 1), an established PtdInsP(3) effector protein. Importantly, the IQGAP1 C-terminal domain and the cytohesin-3 PH domain, each tagged with enhanced green fluorescent protein, both re-localized from the cytosol to the cell periphery following the activation of PI 3-kinase in Swiss 3T3 fibroblasts, consistent with their common, selective recognition of endogenous 3-PI(s). The crystal structure of the C-terminal IQGAP2 PI binding module reveals unexpected topological similarity to an integral fold of C2 domains, including a putative basic binding pocket. We propose that this module integrates select IQGAP proteins with PI 3-kinase signalling and constitutes a novel, atypical phosphoinositide (aPI) binding domain that may represent the first of a larger group, each perhaps structurally unique but collectively dissimilar from the known PI recognition modules.

	~~{{STRUCTURE_4eza\| PDB=4eza \| SCENE= }}~~		IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.,Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH J Biol Chem. 2012 Apr 5. PMID:22493426<ref>PMID:22493426</ref>

	~~===Crystal structure~~ of the ~~atypical phosphoinositide (aPI) binding domain of IQGAP2===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22493426}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4eza]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022493426<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aalten, D M.F Van.]]		[[Category: Aalten, D M.F Van.]]

OCA at 04:37, 18 July 2012

2012-07-18T04:37:41Z

← Older revision		Revision as of 04:37, 18 July 2012
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	[[Image:4eza.~~jpg~~\|left\|200px]]		[[Image:4eza.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_4eza", creates the "Structure Box" on the page.~~
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	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_4eza\| PDB=4eza \| SCENE= }}		{{STRUCTURE_4eza\| PDB=4eza \| SCENE= }}

	===Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2===		===Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22493426}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_22493426}}		{{ABSTRACT_PUBMED_22493426}}

OCA at 09:14, 16 May 2012

2012-05-16T09:14:24Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4eza.jpg|left|200px]]
-The entry 4eza is ON HOLD
+<!--
-Authors: Van Aalten, D.M., Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
+===Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2===
-Description: Crystal structure of the GAP-related domain of IQGAP2

OCA: Protected "4eza" [edit=sysop:move=sysop]

2012-05-09T08:55:09Z

Protected "4eza" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:55, 9 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4eza is ON HOLD Authors: Van Aalten, D.M., Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C...

2012-05-09T08:55:08Z

New page: '''Unreleased structure''' The entry 4eza is ON HOLD Authors: Van Aalten, D.M., Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C...

New page

'''Unreleased structure'''

The entry 4eza is ON HOLD

Authors: Van Aalten, D.M., Nedyalkova, L., Tempel, W., Tong, Y., Zhong, N., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)

Description: Crystal structure of the GAP-related domain of IQGAP2