4f2b - Revision history

OCA at 15:14, 14 March 2024

2024-03-14T15:14:18Z

← Older revision		Revision as of 15:14, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.16Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [https://pdbe.org/4f2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [https://www.ebi.ac.uk/pdbsum/4f2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [https://pdbe.org/4f2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [https://www.ebi.ac.uk/pdbsum/4f2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.		[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Staphylococcus aureus phosphatidylinositol-specific phospholipase C (PI-PLC) is a secreted virulence factor for this pathogenic bacterium. A novel crystal structure shows that this PI-PLC can form a dimer via helix B, a structural feature present in all secreted, bacterial PI-PLCs that is important for membrane binding. Despite the small size of this interface, it is critical for optimal enzyme activity. Kinetic evidence, increased enzyme specific activity with increasing enzyme concentration, supports a mechanism where the PI-PLC dimerization is enhanced in membranes containing phosphatidylcholine (PC). Mutagenesis of key residues confirm that the zwitterionic phospholipid acts not by specific binding to the protein, but rather by reducing anionic lipid interactions with a cationic pocket on the surface of the S. aureus enzyme that stabilizes monomeric protein. Despite its structural and sequence similarity to PI-PLCs from other Gram-positive pathogenic bacteria, S. aureus PI-PLC appears to have a unique mechanism where enzyme activity is modulated by competition between binding of soluble anions or anionic lipids to the cationic sensor and transient dimerization on the membrane.

	Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.,Cheng J, Goldstein R, Stec B, Gershenson A, Roberts MF J Biol Chem. 2012 Nov 23;287(48):40317-27. doi: 10.1074/jbc.M112.395277. Epub, 2012 Oct 4. PMID:23038258<ref>PMID:23038258</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4f2b" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Phospholipase C\|Phospholipase C]]		*[[Phospholipase C\|Phospholipase C]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:29, 7 October 2022

2022-10-07T04:29:40Z

← Older revision		Revision as of 04:29, 7 October 2022
Line 1:		Line 1:

	==Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding==		==Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding==
	<StructureSection load='4f2b' size='340' side='right' caption='[[4f2b]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='4f2b' size='340' side='right'caption='[[4f2b]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staae Staae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4F2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]], [[3v18\|3v18]], [[3v1h\|3v1h]], [[4f2t\|4f2t]], [[4f2u\|4f2u]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [https://pdbe.org/4f2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [https://www.ebi.ac.uk/pdbsum/4f2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2b ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [~~http~~://pdbe.org/4f2b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4f2b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.		[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Phosphatidylinositol diacylglycerol-lyase~~]]		[[Category: Large Structures]]
	[[Category: ~~Staae~~]]		[[Category: Staphylococcus aureus subsp. aureus str. Newman]]
	[[Category: Cheng, J]]		[[Category: Cheng J]]
	[[Category: Gershenson, A]]		[[Category: Gershenson A]]
	[[Category: Goldstein, R]]		[[Category: Goldstein R]]
	[[Category: Roberts~~, M F~~]]		[[Category: Roberts MF]]
	[[Category: Stec, B]]		[[Category: Stec B]]
	~~[[Category: Dimer]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Phosphatidylinositol-specific phospholipase c~~]]

OCA at 18:10, 4 August 2016

2016-08-04T18:10:19Z

← Older revision		Revision as of 18:10, 4 August 2016
Line 1:		Line 1:

	==Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding==		==Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding==
	<StructureSection load='4f2b' size='340' side='right' caption='[[4f2b]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='4f2b' size='340' side='right' caption='[[4f2b]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]], [[3v18\|3v18]], [[3v1h\|3v1h]], [[4f2t\|4f2t]], [[4f2u\|4f2u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]], [[3v18\|3v18]], [[3v1h\|3v1h]], [[4f2t\|4f2t]], [[4f2u\|4f2u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 ~~Staphylococcus aureus subsp. aureus str. Newman~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [http://www.ebi.ac.uk/pdbsum/4f2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [http://pdbe.org/4f2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [http://www.ebi.ac.uk/pdbsum/4f2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4f2b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[~~Phosphatidylinositol-specific phospholipase~~ C\|~~Phosphatidylinositol-specific phospholipase~~ C]]		*[[Phospholipase C\|Phospholipase C]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
	[[Category: ~~Staphylococcus aureus subsp. aureus str. newman~~]]		[[Category: Staae]]
	[[Category: Cheng, J]]		[[Category: Cheng, J]]
	[[Category: Gershenson, A]]		[[Category: Gershenson, A]]

OCA at 18:02, 24 December 2014

2014-12-24T18:02:41Z

← Older revision		Revision as of 18:02, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [http://www.ebi.ac.uk/pdbsum/4f2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [http://www.ebi.ac.uk/pdbsum/4f2b PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:42, 9 December 2014

2014-12-09T16:42:24Z

← Older revision		Revision as of 16:42, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4f2b~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding==
			<StructureSection load='4f2b' size='340' side='right' caption='[[4f2b]], [[Resolution\|resolution]] 2.16Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4f2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2B FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]], [[3v18\|3v18]], [[3v1h\|3v1h]], [[4f2t\|4f2t]], [[4f2u\|4f2u]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 Staphylococcus aureus subsp. aureus str. Newman])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f2b RCSB], [http://www.ebi.ac.uk/pdbsum/4f2b PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Staphylococcus aureus phosphatidylinositol-specific phospholipase C (PI-PLC) is a secreted virulence factor for this pathogenic bacterium. A novel crystal structure shows that this PI-PLC can form a dimer via helix B, a structural feature present in all secreted, bacterial PI-PLCs that is important for membrane binding. Despite the small size of this interface, it is critical for optimal enzyme activity. Kinetic evidence, increased enzyme specific activity with increasing enzyme concentration, supports a mechanism where the PI-PLC dimerization is enhanced in membranes containing phosphatidylcholine (PC). Mutagenesis of key residues confirm that the zwitterionic phospholipid acts not by specific binding to the protein, but rather by reducing anionic lipid interactions with a cationic pocket on the surface of the S. aureus enzyme that stabilizes monomeric protein. Despite its structural and sequence similarity to PI-PLCs from other Gram-positive pathogenic bacteria, S. aureus PI-PLC appears to have a unique mechanism where enzyme activity is modulated by competition between binding of soluble anions or anionic lipids to the cationic sensor and transient dimerization on the membrane.

	~~{{STRUCTURE_4f2b\| PDB=4f2b \| SCENE= }}~~		Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.,Cheng J, Goldstein R, Stec B, Gershenson A, Roberts MF J Biol Chem. 2012 Nov 23;287(48):40317-27. doi: 10.1074/jbc.M112.395277. Epub, 2012 Oct 4. PMID:23038258<ref>PMID:23038258</ref>

	~~===Modulation~~ of S.~~Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23038258}}~~		==See Also==
			*[[Phosphatidylinositol-specific phospholipase C\|Phosphatidylinositol-specific phospholipase C]]
	==~~About this Structure~~==		== References ==
	[[~~4f2b~~]] ~~is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA].		<references/>
			__TOC__
			</StructureSection>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
	[[Category: Staphylococcus aureus subsp. aureus str. newman]]		[[Category: Staphylococcus aureus subsp. aureus str. newman]]
	[[Category: Cheng, J.]]		[[Category: Cheng, J]]
	[[Category: Gershenson, A.]]		[[Category: Gershenson, A]]
	[[Category: Goldstein, R.]]		[[Category: Goldstein, R]]
	[[Category: Roberts, M F.]]		[[Category: Roberts, M F]]
	[[Category: Stec, B.]]		[[Category: Stec, B]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Phosphatidylinositol-specific phospholipase c]]		[[Category: Phosphatidylinositol-specific phospholipase c]]

OCA at 21:19, 12 December 2012

2012-12-12T21:19:16Z

← Older revision		Revision as of 21:19, 12 December 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4f2b.jpg\|left\|200px]]

	~~The entry~~ 4f2b ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4f2b\| PDB=4f2b \| SCENE= }}

	~~Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F~~.		===Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding===

	~~Description~~: ~~Modulation of S~~.~~Aureus~~ Phosphatidylinositol-~~Specific Phospholipase C Membrane Binding~~		{{ABSTRACT_PUBMED_23038258}}

			==About this Structure==
			[[4f2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2B OCA].
			[[Category: Phosphatidylinositol diacylglycerol-lyase]]
			[[Category: Staphylococcus aureus subsp. aureus str. newman]]
			[[Category: Cheng, J.]]
			[[Category: Gershenson, A.]]
			[[Category: Goldstein, R.]]
			[[Category: Roberts, M F.]]
			[[Category: Stec, B.]]
			[[Category: Dimer]]
			[[Category: Lyase]]
			[[Category: Phosphatidylinositol-specific phospholipase c]]

OCA at 04:46, 12 September 2012

2012-09-12T04:46:29Z

← Older revision		Revision as of 04:46, 12 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4f2b is ON HOLD		The entry 4f2b is ON HOLD until Paper Publication

	Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.		Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.

	Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding		Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding

OCA at 07:45, 11 July 2012

2012-07-11T07:45:52Z

← Older revision		Revision as of 07:45, 11 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4f2b is ON HOLD ~~until sometime in the future~~		The entry 4f2b is ON HOLD

	Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.		Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.

	Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding		Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding

OCA at 07:22, 20 June 2012

2012-06-20T07:22:29Z

← Older revision		Revision as of 07:22, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4f2b is ON HOLD		The entry 4f2b is ON HOLD until sometime in the future

	Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.		Authors: Cheng, J., Goldstein, R., Stec, B., Gershenson, A., Roberts, M.F.

	Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding		Description: Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding

OCA: Protected "4f2b" [edit=sysop:move=sysop]

2012-05-16T08:54:13Z

Protected "4f2b" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:54, 16 May 2012
(No difference)