4fa8 - Revision history

OCA at 02:52, 21 November 2024

2024-11-21T02:52:28Z

← Older revision		Revision as of 02:52, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [https://pdbe.org/4fa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fa8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [https://pdbe.org/4fa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fa8 ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~BARF1_EBVG BARF1_EBVG~~] Plays ~~diverse functions~~ in ~~immunomodulation~~ and ~~oncogenicity~~, ~~maybe by acting as a functional receptor~~ for ~~human CSF1~~. ~~May inhibit interferon secretion from mononuclear cells~~. ~~Exhibits oncogenic activity~~ in ~~vitro (By similarity)~~.		[https://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:44, 7 October 2022

2022-10-07T04:44:28Z

← Older revision		Revision as of 04:44, 7 October 2022
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	==Multi-pronged modulation of cytokine signaling==		==Multi-pronged modulation of cytokine signaling==
	<StructureSection load='4fa8' size='340' side='right' caption='[[4fa8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4fa8' size='340' side='right'caption='[[4fa8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ebvg Ebvg~~] and [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 EBVG]), CSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [https://pdbe.org/4fa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fa8 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [~~http~~://pdbe.org/4fa8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fa8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fa8 ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref>		[https://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4fa8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fa8" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Colony-stimulating factor 3D structures\|Colony-stimulating factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ebvg~~]]		[[Category: Homo sapiens]]
	[[Category: Human]]		[[Category: Human gammaherpesvirus 4]]
	[[Category: ~~He, X~~]]		[[Category: Large Structures]]
	[[Category: ~~Shim, A H~~]]		[[Category: He X]]
	[[Category: ~~4-helix bundle fold]]~~		[[Category: Shim AH]]
	~~[[Category: Immunoglobulin-like domain]]~~
	~~[[Category: Viral protein-cytokine complex~~]]

OCA at 02:09, 5 August 2016

2016-08-05T02:09:57Z

← Older revision		Revision as of 02:09, 5 August 2016
Line 1:		Line 1:

	==Multi-pronged modulation of cytokine signaling==		==Multi-pronged modulation of cytokine signaling==
	<StructureSection load='4fa8' size='340' side='right' caption='[[4fa8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4fa8' size='340' side='right' caption='[[4fa8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Human_herpesvirus_4~~ Human ~~herpesvirus 4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 ~~Human herpesvirus 4~~]), CSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 EBVG]), CSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fa8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [http://pdbe.org/4fa8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fa8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fa8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4fa8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Ebvg]]
	[[Category: Human ~~herpesvirus 4~~]]		[[Category: Human]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Shim, A H]]		[[Category: Shim, A H]]

OCA at 11:34, 21 December 2014

2014-12-21T11:34:50Z

← Older revision		Revision as of 11:34, 21 December 2014
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	~~{{STRUCTURE_4fa8~~\| ~~PDB~~=4fa8 \| ~~SCENE~~= }}		==Multi-pronged modulation of cytokine signaling==
	===~~Multi~~-pronged ~~modulation~~ of ~~cytokine~~ signaling~~===~~		<StructureSection load='4fa8' size='340' side='right' caption='[[4fa8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	~~{{ABSTRACT_PUBMED_22826234}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4fa8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FA8 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4]), CSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fa8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fa8 RCSB], [http://www.ebi.ac.uk/pdbsum/4fa8 PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref> <ref>PMID:19934330</ref> <ref>PMID:20829061</ref> <ref>PMID:20504948</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The ubiquitous EBV causes infectious mononucleosis and is associated with several types of cancers. The EBV genome encodes an early gene product, BARF1, which contributes to pathogenesis, potentially through growth-altering and immune-modulating activities, but the mechanisms for such activities are poorly understood. We have determined the crystal structure of BARF1 in complex with human macrophage-colony stimulating factor (M-CSF), a hematopoietic cytokine with pleiotropic functions in development and immune response. BARF1 and M-CSF form a high-affinity, stable, ring-like complex in both solution and the crystal, with a BARF1 hexameric ring surrounded by three M-CSF dimers in triangular array. The binding of BARF1 to M-CSF dramatically reduces but does not completely abolish M-CSF binding and signaling through its cognate receptor FMS. A three-pronged down-regulation mechanism is proposed to explain the biological effect of BARF1 on M-CSF:FMS signaling. These prongs entail control of the circulating and effective local M-CSF concentration, perturbation of the receptor-binding surface of M-CSF, and imposition of an unfavorable global orientation of the M-CSF dimer. Each prong may reduce M-CSF:FMS signaling to a limited extent but in combination may alter M-CSF:FMS signaling dramatically. The downregulating mechanism of BARF1 underlines a viral modulation strategy, and provides a basis for understanding EBV pathogenesis.

	~~==Disease==~~		Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.,Shim AH, Chang RA, Chen X, Longnecker R, He X Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12962-7. Epub 2012 Jul 23. PMID:22826234<ref>PMID:22826234</ref>
	~~[[http://www~~.~~uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation~~, ~~invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast~~, ~~ovarian~~, ~~prostate~~, ~~and endometrial cancers~~.~~<ref>PMID~~:16337366</ref><ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.~~<ref>~~PMID:~~16337366</ref>~~<ref>PMID:~~19934330~~</ref>

	~~==Function==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[http:~~/~~/www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity~~, ~~maybe by acting as~~ a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of ~~hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes~~ the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. ~~Required for normal male and female fertility~~. ~~Promotes reorganization of the actin cytoskeleton, regulates formation~~ of ~~membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance~~.<~~ref~~>~~PMID:16337366</ref><ref>PMID:19934330~~</~~ref><ref~~>~~PMID:20829061</ref><ref>PMID:20504948</ref>~~		</div>
			== References ==
	~~==About this Structure==~~		<references/>
	[[4fa8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA].		__TOC__
			</StructureSection>
	==~~Reference~~==
	~~<ref group="xtra">PMID:022826234</ref>~~<references ~~group="xtra"~~/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]
	[[Category: He, X.]]		[[Category: He, X]]
	[[Category: Shim, A H.]]		[[Category: Shim, A H]]
	[[Category: 4-helix bundle fold]]		[[Category: 4-helix bundle fold]]
	[[Category: Immunoglobulin-like domain]]		[[Category: Immunoglobulin-like domain]]
	[[Category: Viral protein-cytokine complex]]		[[Category: Viral protein-cytokine complex]]

OCA at 07:06, 25 March 2013

2013-03-25T07:06:35Z

← Older revision		Revision as of 07:06, 25 March 2013
Line 1:		Line 1:
	~~[[Image:4fa8.jpg\|left\|200px]]~~

	{{STRUCTURE_4fa8\| PDB=4fa8 \| SCENE= }}		{{STRUCTURE_4fa8\| PDB=4fa8 \| SCENE= }}
			===Multi-pronged modulation of cytokine signaling===
			{{ABSTRACT_PUBMED_22826234}}

	===~~Multi-pronged modulation of cytokine signaling~~===		==Disease==
			[[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref><ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref><ref>PMID:19934330</ref>

	~~{{ABSTRACT_PUBMED_22826234}}~~		==Function==
			[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref><ref>PMID:19934330</ref><ref>PMID:20829061</ref><ref>PMID:20504948</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:022826234</ref><references group="xtra"/>		<ref group="xtra">PMID:022826234</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]

OCA at 05:14, 29 August 2012

2012-08-29T05:14:49Z

← Older revision		Revision as of 05:14, 29 August 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4fa8.jpg\|left\|200px]]

	~~The entry~~ 4fa8 ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4fa8\| PDB=4fa8 \| SCENE= }}

	~~Authors: He, X., Shim, A.H.~~		===Multi-pronged modulation of cytokine signaling===

	~~Description~~: ~~Multi~~-~~pronged modulation of~~ cytokine ~~signaling~~		{{ABSTRACT_PUBMED_22826234}}

			==About this Structure==
			[[4fa8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FA8 OCA].

			==Reference==
			<ref group="xtra">PMID:022826234</ref><references group="xtra"/>
			[[Category: Homo sapiens]]
			[[Category: Human herpesvirus 4]]
			[[Category: He, X.]]
			[[Category: Shim, A H.]]
			[[Category: 4-helix bundle fold]]
			[[Category: Immunoglobulin-like domain]]
			[[Category: Viral protein-cytokine complex]]

OCA at 07:46, 11 July 2012

2012-07-11T07:46:22Z

← Older revision		Revision as of 07:46, 11 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fa8 is ON HOLD		The entry 4fa8 is ON HOLD until Paper Publication

	Authors: He, X., Shim, A.H.		Authors: He, X., Shim, A.H.

	Description: Multi-pronged modulation of cytokine signaling		Description: Multi-pronged modulation of cytokine signaling

OCA at 05:22, 27 June 2012

2012-06-27T05:22:37Z

← Older revision		Revision as of 05:22, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fa8 is ON HOLD ~~until sometime in the future~~		The entry 4fa8 is ON HOLD

	Authors: He, X, Shim, A.H.		Authors: He, X., Shim, A.H.

	Description: Multi-pronged modulation of cytokine signaling		Description: Multi-pronged modulation of cytokine signaling

OCA at 07:23, 20 June 2012

2012-06-20T07:23:28Z

← Older revision		Revision as of 07:23, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fa8 is ON HOLD		The entry 4fa8 is ON HOLD until sometime in the future

	Authors: He, X, Shim, A.H.		Authors: He, X, Shim, A.H.

	Description: Multi-pronged modulation of cytokine signaling		Description: Multi-pronged modulation of cytokine signaling

OCA: Protected "4fa8" [edit=sysop:move=sysop]

2012-05-30T05:33:34Z

Protected "4fa8" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:33, 30 May 2012
(No difference)