4fcb - Revision history

OCA at 11:13, 1 March 2024

2024-03-01T11:13:48Z

← Older revision		Revision as of 11:13, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [https://pdbe.org/4fcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [https://www.ebi.ac.uk/pdbsum/4fcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [https://pdbe.org/4fcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [https://www.ebi.ac.uk/pdbsum/4fcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>		[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show desired drug-like properties. Employing structure-based drug design approaches, we investigated the selectivity of PDE10A inhibitors against other known PDE isoforms, by methodically exploring the various sub-regions of the PDE10A ligand binding pocket. A systematic assessment of the ADME and pharmacokinetic properties of the newly synthesized compounds has led to the design of drug-like candidates with good brain permeability and desirable drug kinetics (t(1/2), bioavailability, clearance). Compound 66 was highly potent for PDE10A (IC(50)=1.4nM), demonstrated high selectivity (>200x) for the other PDEs, and was efficacious in animal models of psychoses; reversal of MK-801 induced hyperactivity (MED=0.1mg/kg) and conditioned avoidance responding (CAR; ID(50)=0.2mg/kg).

	Novel triazines as potent and selective phosphodiesterase 10A inhibitors.,Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Brandon NJ, Hoefgen N Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84. Epub 2012 Jul 31. PMID:22902656<ref>PMID:22902656</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 04:48, 7 October 2022

2022-10-07T04:48:30Z

← Older revision		Revision as of 04:48, 7 October 2022
Line 1:		Line 1:

	==Potent and Selective Phosphodiesterase 10A Inhibitors==		==Potent and Selective Phosphodiesterase 10A Inhibitors==
	<StructureSection load='4fcb' size='340' side='right' caption='[[4fcb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4fcb' size='340' side='right'caption='[[4fcb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcd\|4fcd]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [https://pdbe.org/4fcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [https://www.ebi.ac.uk/pdbsum/4fcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcb ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [~~http~~://pdbe.org/4fcb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fcb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>		[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Parris, K D~~]]		[[Category: Large Structures]]
	[[Category: ~~Binding site]]~~		[[Category: Parris KD]]
	~~[[Category: Cyclic amp]]~~
	~~[[Category: Cyclic gmp]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Ligand]]~~
	~~[[Category: Phosphodiesterase inhibitor~~]]

OCA at 08:15, 15 November 2017

2017-11-15T08:15:44Z

← Older revision		Revision as of 08:15, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:52, 4 August 2016

2016-08-04T08:52:34Z

← Older revision		Revision as of 08:52, 4 August 2016
Line 1:		Line 1:

	==Potent and Selective Phosphodiesterase 10A Inhibitors==		==Potent and Selective Phosphodiesterase 10A Inhibitors==
	<StructureSection load='4fcb' size='340' side='right' caption='[[4fcb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4fcb' size='340' side='right' caption='[[4fcb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcd\|4fcd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcd\|4fcd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [http://www.ebi.ac.uk/pdbsum/4fcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [http://pdbe.org/4fcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [http://www.ebi.ac.uk/pdbsum/4fcb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4fcb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Parris, K D]]		[[Category: Parris, K D]]
	[[Category: Binding site]]		[[Category: Binding site]]

OCA at 07:54, 24 December 2014

2014-12-24T07:54:41Z

← Older revision		Revision as of 07:54, 24 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4fcb~~.~~png~~\|~~left~~\|~~200px~~]]		==Potent and Selective Phosphodiesterase 10A Inhibitors==
			<StructureSection load='4fcb' size='340' side='right' caption='[[4fcb]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4fcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T7:3,4-DIMETHYL-1-PROPYL-7-(QUINOLIN-2-YLMETHOXY)IMIDAZO[1,5-A]QUINOXALINE'>0T7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcd\|4fcd]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fcb RCSB], [http://www.ebi.ac.uk/pdbsum/4fcb PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show desired drug-like properties. Employing structure-based drug design approaches, we investigated the selectivity of PDE10A inhibitors against other known PDE isoforms, by methodically exploring the various sub-regions of the PDE10A ligand binding pocket. A systematic assessment of the ADME and pharmacokinetic properties of the newly synthesized compounds has led to the design of drug-like candidates with good brain permeability and desirable drug kinetics (t(1/2), bioavailability, clearance). Compound 66 was highly potent for PDE10A (IC(50)=1.4nM), demonstrated high selectivity (>200x) for the other PDEs, and was efficacious in animal models of psychoses; reversal of MK-801 induced hyperactivity (MED=0.1mg/kg) and conditioned avoidance responding (CAR; ID(50)=0.2mg/kg).

	~~{{STRUCTURE_4fcb\| PDB=4fcb \| SCENE= }}~~		Novel triazines as potent and selective phosphodiesterase 10A inhibitors.,Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, Navarra R, Graf R, Harrison BL, Robichaud A, Kronbach T, Pangalos MN, Brandon NJ, Hoefgen N Bioorg Med Chem Lett. 2012 Sep 15;22(18):5876-84. Epub 2012 Jul 31. PMID:22902656<ref>PMID:22902656</ref>

	~~===Potent and Selective Phosphodiesterase 10A Inhibitors===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_22902656}}~~		==See Also==
			*[[Phosphodiesterase\|Phosphodiesterase]]
	==~~About this Structure~~==		== References ==
	[[~~4fcb~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Parris, K D.]]		[[Category: Parris, K D]]
	[[Category: Binding site]]		[[Category: Binding site]]
	[[Category: Cyclic amp]]		[[Category: Cyclic amp]]

OCA at 08:11, 2 January 2013

2013-01-02T08:11:45Z

← Older revision		Revision as of 08:11, 2 January 2013
Line 1:		Line 1:
	[[Image:4fcb.~~jpg~~\|left\|200px]]		[[Image:4fcb.png\|left\|200px]]

	{{STRUCTURE_4fcb\| PDB=4fcb \| SCENE= }}		{{STRUCTURE_4fcb\| PDB=4fcb \| SCENE= }}

OCA at 05:22, 5 September 2012

2012-09-05T05:22:04Z

← Older revision		Revision as of 05:22, 5 September 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4fcb.jpg\|left\|200px]]

	~~The entry~~ 4fcb ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4fcb\| PDB=4fcb \| SCENE= }}

	~~Authors: Parris, K.D.~~		===Potent and Selective Phosphodiesterase 10A Inhibitors===

	~~Description~~: ~~Potent and Selective~~ Phosphodiesterase ~~10A Inhibitors~~		{{ABSTRACT_PUBMED_22902656}}

			==About this Structure==
			[[4fcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCB OCA].
			[[Category: Homo sapiens]]
			[[Category: Parris, K D.]]
			[[Category: Binding site]]
			[[Category: Cyclic amp]]
			[[Category: Cyclic gmp]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
			[[Category: Ligand]]
			[[Category: Phosphodiesterase inhibitor]]

OCA at 07:21, 6 June 2012

2012-06-06T07:21:10Z

← Older revision		Revision as of 07:21, 6 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fcb is ON HOLD		The entry 4fcb is ON HOLD until Paper Publication

	Authors: Parris, K. D.		Authors: Parris, K.D.

	Description: Potent and Selective Phosphodiesterase 10A Inhibitors		Description: Potent and Selective Phosphodiesterase 10A Inhibitors

OCA: Protected "4fcb" [edit=sysop:move=sysop]

2012-05-30T05:35:30Z

Protected "4fcb" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:35, 30 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4fcb is ON HOLD Authors: Parris, K. D. Description: Potent and Selective Phosphodiesterase 10A Inhibitors

2012-05-30T05:35:29Z

New page: '''Unreleased structure''' The entry 4fcb is ON HOLD Authors: Parris, K. D. Description: Potent and Selective Phosphodiesterase 10A Inhibitors

New page

'''Unreleased structure'''

The entry 4fcb is ON HOLD

Authors: Parris, K. D.

Description: Potent and Selective Phosphodiesterase 10A Inhibitors