4fcc - Revision history

OCA at 11:13, 1 March 2024

2024-03-01T11:13:49Z

← Older revision		Revision as of 11:13, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [https://pdbe.org/4fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [https://www.ebi.ac.uk/pdbsum/4fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcc ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [https://pdbe.org/4fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [https://www.ebi.ac.uk/pdbsum/4fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8XDW9_ECO57 Q8XDW9_ECO57]		[https://www.uniprot.org/uniprot/Q8XDW9_ECO57 Q8XDW9_ECO57]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of approximately 30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we have characterized the species-specific scaffold nucleoporin Nup37 and ELY5/ELYS. Both proteins integrate directly via Nup120/160 into the universally conserved heptameric Y-complex, the critical unit for the assembly and functionality of the NPC. We present the crystal structure of Schizosaccharomyces pombe Nup37 in complex with Nup120, a 174-kDa subassembly that forms one of the two short arms of the Y-complex. Nup37 binds near the bend of the L-shaped Nup120 protein, potentially stabilizing the relative orientation of its two domains. By means of reconstitution assays, we pinpoint residues crucial for this interaction. In vivo and in vitro results show that ELY5 binds near an interface of the Nup120-Nup37 complex. Complementary biochemical and cell biological data refine and consolidate the interactions of Nup120 within the current Y-model. Finally, we propose an orientation of the Y-complex relative to the pore membrane, consistent with the lattice model.

	Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.,Bilokapic S, Schwartz TU Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15241-6. Epub 2012 Sep 5. PMID:22955883<ref>PMID:22955883</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4fcc" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Glutamate dehydrogenase 3D structures\|Glutamate dehydrogenase 3D structures]]		*[[Glutamate dehydrogenase 3D structures\|Glutamate dehydrogenase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:48, 7 October 2022

2022-10-07T04:48:31Z

← Older revision		Revision as of 04:48, 7 October 2022
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	~~{{Large structure}}~~
	==Glutamate dehydrogenase from E. coli==		==Glutamate dehydrogenase from E. coli==
	<StructureSection load='4fcc' size='340' side='right' caption='[[4fcc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4fcc' size='340' side='right'caption='[[4fcc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Eco57 Eco57~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCC FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fhl\|4fhl]], [[4fhm\|4fhm]], [[4fhn\|4fhn]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [https://pdbe.org/4fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [https://www.ebi.ac.uk/pdbsum/4fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcc ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gdhA, ECs2467, Z2793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [~~http~~://pdbe.org/4fcc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fcc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcc ProSAT]</span></td></tr>
	</table>		</table>
	~~{{Large structure}}~~		== Function ==
			[https://www.uniprot.org/uniprot/Q8XDW9_ECO57 Q8XDW9_ECO57]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:

	==See Also==		==See Also==
	*[[Glutamate dehydrogenase\|Glutamate dehydrogenase]]		*[[Glutamate dehydrogenase 3D structures\|Glutamate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Eco57]]~~		[[Category: Escherichia coli O157:H7]]
	~~[[Category~~: ~~Bilokapic, S~~]]		[[Category: Large Structures]]
	[[Category: ~~Schwartz, T U~~]]		[[Category: Bilokapic S]]
	[[Category: ~~Metabolic role~~]]		[[Category: Schwartz TU]]
	[[Category: ~~Nad]]~~
	~~[[Category: Nadp]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Protein complex]]~~
	~~[[Category: Rossmann fold~~]]

OCA at 16:35, 5 August 2016

2016-08-05T16:35:14Z

← Older revision		Revision as of 16:35, 5 August 2016
Line 1:		Line 1:
			{{Large structure}}
	==Glutamate dehydrogenase from E. coli==		==Glutamate dehydrogenase from E. coli==
	<StructureSection load='4fcc' size='340' side='right' caption='[[4fcc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4fcc' size='340' side='right' caption='[[4fcc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_o157:h7 Escherichia coli o157:h7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fhl\|4fhl]], [[4fhm\|4fhm]], [[4fhn\|4fhn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fhl\|4fhl]], [[4fhm\|4fhm]], [[4fhn\|4fhn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gdhA, ECs2467, Z2793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ~~Escherichia coli O157:H7~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gdhA, ECs2467, Z2793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [http://www.ebi.ac.uk/pdbsum/4fcc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [http://pdbe.org/4fcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [http://www.ebi.ac.uk/pdbsum/4fcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcc ProSAT]</span></td></tr>
	</table>		</table>
			{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4fcc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli o157:h7~~]]		[[Category: Eco57]]
	[[Category: Bilokapic, S]]		[[Category: Bilokapic, S]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]

OCA at 08:41, 18 December 2014

2014-12-18T08:41:07Z

← Older revision		Revision as of 08:41, 18 December 2014
Line 1:		Line 1:
	~~{{Large structure}}~~		==Glutamate dehydrogenase from E. coli==
	~~{{STRUCTURE_4fcc~~\| ~~PDB~~=4fcc \| ~~SCENE~~= }}		<StructureSection load='4fcc' size='340' side='right' caption='[[4fcc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	===~~Glutamate dehydrogenase from E~~. coli===		== Structural highlights ==
	~~{{ABSTRACT_PUBMED_22955883}}~~		<table><tr><td colspan='2'>[[4fcc]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FCC FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fhl\|4fhl]], [[4fhm\|4fhm]], [[4fhn\|4fhn]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gdhA, ECs2467, Z2793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 Escherichia coli O157:H7])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fcc RCSB], [http://www.ebi.ac.uk/pdbsum/4fcc PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of approximately 30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we have characterized the species-specific scaffold nucleoporin Nup37 and ELY5/ELYS. Both proteins integrate directly via Nup120/160 into the universally conserved heptameric Y-complex, the critical unit for the assembly and functionality of the NPC. We present the crystal structure of Schizosaccharomyces pombe Nup37 in complex with Nup120, a 174-kDa subassembly that forms one of the two short arms of the Y-complex. Nup37 binds near the bend of the L-shaped Nup120 protein, potentially stabilizing the relative orientation of its two domains. By means of reconstitution assays, we pinpoint residues crucial for this interaction. In vivo and in vitro results show that ELY5 binds near an interface of the Nup120-Nup37 complex. Complementary biochemical and cell biological data refine and consolidate the interactions of Nup120 within the current Y-model. Finally, we propose an orientation of the Y-complex relative to the pore membrane, consistent with the lattice model.

	~~==About this Structure==~~		Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.,Bilokapic S, Schwartz TU Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15241-6. Epub 2012 Sep 5. PMID:22955883<ref>PMID:22955883</ref>
	~~[[4fcc]] is a 12 chain structure with sequence from [http:/~~/en.~~wikipedia~~.~~org/wiki/Escherichia_coli_o157~~:~~h7 Escherichia coli o157~~:~~h7]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4FCC OCA~~].
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
			*[[Glutamate dehydrogenase\|Glutamate dehydrogenase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Escherichia coli o157:h7]]		[[Category: Escherichia coli o157:h7]]
	[[Category: Bilokapic, S.]]		[[Category: Bilokapic, S]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U]]
	[[Category: Metabolic role]]		[[Category: Metabolic role]]
	[[Category: Nad]]		[[Category: Nad]]

OCA at 08:32, 11 March 2013

2013-03-11T08:32:36Z

← Older revision		Revision as of 08:32, 11 March 2013
Line 1:		Line 1:
	~~[[Image:4fcc.png\|left\|200px]]~~		{{Large structure}}

	{{STRUCTURE_4fcc\| PDB=4fcc \| SCENE= }}		{{STRUCTURE_4fcc\| PDB=4fcc \| SCENE= }}

	===Glutamate dehydrogenase from E. coli===		===Glutamate dehydrogenase from E. coli===

	{{ABSTRACT_PUBMED_22955883}}		{{ABSTRACT_PUBMED_22955883}}

OCA at 06:36, 3 October 2012

2012-10-03T06:36:00Z

← Older revision		Revision as of 06:36, 3 October 2012
Line 1:		Line 1:
	[[Image:4fcc.~~jpg~~\|left\|200px]]		[[Image:4fcc.png\|left\|200px]]

	{{STRUCTURE_4fcc\| PDB=4fcc \| SCENE= }}		{{STRUCTURE_4fcc\| PDB=4fcc \| SCENE= }}

	===Glutamate dehydrogenase from E.~~COLI~~===		===Glutamate dehydrogenase from E. coli===

	{{ABSTRACT_PUBMED_22955883}}		{{ABSTRACT_PUBMED_22955883}}

OCA at 20:29, 26 September 2012

2012-09-26T20:29:26Z

← Older revision		Revision as of 20:29, 26 September 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4fcc.jpg\|left\|200px]]

	~~The entry~~ 4fcc ~~is ON HOLD~~		{{STRUCTURE_4fcc\| PDB=4fcc \| SCENE= }}

	~~Authors: Bilokapic, S~~.		===Glutamate dehydrogenase from E.COLI===

	~~Description~~: ~~Structure Analysis of~~ Protein ~~Complex~~		{{ABSTRACT_PUBMED_22955883}}

			==About this Structure==
			[[4fcc]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCC OCA].
			[[Category: Escherichia coli o157:h7]]
			[[Category: Bilokapic, S.]]
			[[Category: Schwartz, T U.]]
			[[Category: Metabolic role]]
			[[Category: Nad]]
			[[Category: Nadp]]
			[[Category: Oxidoreductase]]
			[[Category: Protein complex]]
			[[Category: Rossmann fold]]

OCA: Protected "4fcc" [edit=sysop:move=sysop]

2012-05-30T05:35:31Z

Protected "4fcc" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:35, 30 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4fcc is ON HOLD Authors: Bilokapic, S. Description: Structure Analysis of Protein Complex

2012-05-30T05:35:30Z

New page: '''Unreleased structure''' The entry 4fcc is ON HOLD Authors: Bilokapic, S. Description: Structure Analysis of Protein Complex

New page

'''Unreleased structure'''

The entry 4fcc is ON HOLD

Authors: Bilokapic, S.

Description: Structure Analysis of Protein Complex