4fe2 - Revision history

OCA at 15:22, 14 March 2024

2024-03-14T15:22:53Z

← Older revision		Revision as of 15:22, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FE2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.288Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [https://pdbe.org/4fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fe2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [https://pdbe.org/4fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fe2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PUR7_STRPN PUR7_STRPN]		[https://www.uniprot.org/uniprot/PUR7_STRPN PUR7_STRPN]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Streptococcus pneumoniae is a multidrug-resistant pathogen that is a target of considerable interest for antibacterial drug development. One strategy for drug discovery is to inhibit an essential metabolic enzyme. The seventh step of the de novo purine-biosynthesis pathway converts carboxyaminoimidazoleribonucleotide (CAIR) and L-aspartic acid (Asp) to 4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide (SAICAR) in the presence of adenosine 5'-triphosphate (ATP) using the enzyme PurC. PurC has been shown to be conditionally essential for bacterial replication. Two crystal structures of this essential enzyme from Streptococcus pneumoniae (spPurC) in the presence of adenosine 5'-diphosphate (ADP), Mg(2+), aminoimidazoleribonucleotide (AIR) and/or Asp have been obtained. This is the first structural study of spPurC, as well as the first of PurC from any species with Asp in the active site. Based on these findings, two model structures are proposed for the active site with all of the essential ligands (ATP, Mg(2+), Asp and CAIR) present, and a relay mechanism for the formation of the product SAICAR is suggested.

	Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp.,Wolf NM, Abad-Zapatero C, Johnson ME, Fung LW Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):841-50. doi:, 10.1107/S139900471303366X. Epub 2014 Feb 22. PMID:24598753<ref>PMID:24598753</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4fe2" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[SAICAR synthetase\|SAICAR synthetase]]		*[[SAICAR synthetase\|SAICAR synthetase]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:51, 7 October 2022

2022-10-07T04:51:13Z

← Older revision		Revision as of 04:51, 7 October 2022
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	==X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+==		==X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+==
	<StructureSection load='4fe2' size='340' side='right' caption='[[4fe2]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4fe2' size='340' side='right'caption='[[4fe2]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fe2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FE2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purC, SP_0044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [https://pdbe.org/4fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/4fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fe2 ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [~~http~~://pdbe.org/4fe2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fe2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fe2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/PUR7_STRPN PUR7_STRPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4fe2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4fe2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[SAICAR synthetase\|SAICAR synthetase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Phosphoribosylaminoimidazolesuccinocarboxamide synthase~~]]		[[Category: Large Structures]]
	[[Category: Abad-Zapatero, C]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Fung~~, L M.~~W]]		[[Category: Abad-Zapatero C]]
	[[Category: Johnson~~, M E~~]]		[[Category: Fung LM-W]]
	[[Category: Wolf, N]]		[[Category: Johnson ME]]
	~~[[Category: Alpha/beta protein]]~~		[[Category: Wolf N]]
	~~[[Category: Asp]]~~
	~~[[Category: Cair]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Saicar synthetase~~]]

OCA at 08:58, 11 August 2016

2016-08-11T08:58:10Z

← Older revision		Revision as of 08:58, 11 August 2016
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	==X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+==		==X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+==
	<StructureSection load='4fe2' size='340' side='right' caption='[[4fe2]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4fe2' size='340' side='right' caption='[[4fe2]], [[Resolution\|resolution]] 2.29Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purC, SP_0044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purC, SP_0044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fe2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [http://pdbe.org/4fe2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fe2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fe2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4fe2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:14, 4 January 2015

2015-01-04T12:14:41Z

← Older revision		Revision as of 12:14, 4 January 2015
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	~~{{STRUCTURE_4fe2\| PDB=4fe2 \| SCENE= }}~~		==X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+==
	===X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+===		<StructureSection load='4fe2' size='340' side='right' caption='[[4fe2]], [[Resolution\|resolution]] 2.29Å' scene=''>
	~~{{ABSTRACT_PUBMED_24598753}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FE2 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purC, SP_0044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/4fe2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Streptococcus pneumoniae is a multidrug-resistant pathogen that is a target of considerable interest for antibacterial drug development. One strategy for drug discovery is to inhibit an essential metabolic enzyme. The seventh step of the de novo purine-biosynthesis pathway converts carboxyaminoimidazoleribonucleotide (CAIR) and L-aspartic acid (Asp) to 4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide (SAICAR) in the presence of adenosine 5'-triphosphate (ATP) using the enzyme PurC. PurC has been shown to be conditionally essential for bacterial replication. Two crystal structures of this essential enzyme from Streptococcus pneumoniae (spPurC) in the presence of adenosine 5'-diphosphate (ADP), Mg(2+), aminoimidazoleribonucleotide (AIR) and/or Asp have been obtained. This is the first structural study of spPurC, as well as the first of PurC from any species with Asp in the active site. Based on these findings, two model structures are proposed for the active site with all of the essential ligands (ATP, Mg(2+), Asp and CAIR) present, and a relay mechanism for the formation of the product SAICAR is suggested.

	~~==About this Structure==~~		Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp.,Wolf NM, Abad-Zapatero C, Johnson ME, Fung LW Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):841-50. doi:, 10.1107/S139900471303366X. Epub 2014 Feb 22. PMID:24598753<ref>PMID:24598753</ref>
	~~[[4fe2]] is a~~ 2 ~~chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"diplococcus_pneumoniae"_~~(~~klein_1884~~)~~_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4FE2 OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024598753</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]		[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
	[[Category: Abad-Zapatero, C.]]		[[Category: Abad-Zapatero, C]]
	[[Category: Fung, L M.W.]]		[[Category: Fung, L M.W]]
	[[Category: Johnson, M E.]]		[[Category: Johnson, M E]]
	[[Category: Wolf, N.]]		[[Category: Wolf, N]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Asp]]		[[Category: Asp]]

OCA at 07:03, 2 April 2014

2014-04-02T07:03:04Z

← Older revision		Revision as of 07:03, 2 April 2014
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	{{STRUCTURE_4fe2\| PDB=4fe2 \| SCENE= }}		{{STRUCTURE_4fe2\| PDB=4fe2 \| SCENE= }}
	===X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+===		===X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+===
			{{ABSTRACT_PUBMED_24598753}}

	==About this Structure==		==About this Structure==
	[[4fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA].		[[4fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA].

			==Reference==
			<ref group="xtra">PMID:024598753</ref><references group="xtra"/><references/>
	[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]		[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
	~~[[Category: Streptococcus pneumoniae]]~~
	[[Category: Abad-Zapatero, C.]]		[[Category: Abad-Zapatero, C.]]
	[[Category: Fung, L M.W.]]		[[Category: Fung, L M.W.]]

OCA at 16:18, 19 June 2013

2013-06-19T16:18:46Z

← Older revision		Revision as of 16:18, 19 June 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_4fe2\| PDB=4fe2 \| SCENE= }}
			===X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+===

	~~The entry~~ 4fe2 is ~~ON HOLD until Paper Publication~~		==About this Structure==
			[[4fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FE2 OCA].
	~~Authors~~: ~~Wolf, N.,~~ Abad-Zapatero, C., Johnson, M.E., ~~Fung, L.M.-W~~.		[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
			[[Category: Streptococcus pneumoniae]]
	~~Description~~: ~~X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP,~~ Asp ~~and Mg2+~~		[[Category: Abad-Zapatero, C.]]
			[[Category: Fung, L M.W.]]
			[[Category: Johnson, M E.]]
			[[Category: Wolf, N.]]
			[[Category: Alpha/beta protein]]
			[[Category: Asp]]
			[[Category: Cair]]
			[[Category: Ligase]]
			[[Category: Saicar synthetase]]

OCA at 07:24, 20 June 2012

2012-06-20T07:24:31Z

← Older revision		Revision as of 07:24, 20 June 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fe2 is ON HOLD		The entry 4fe2 is ON HOLD until Paper Publication

	Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L.M.-W.		Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L.M.-W.

	Description: X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+		Description: X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+

OCA at 05:50, 13 June 2012

2012-06-13T05:50:24Z

← Older revision		Revision as of 05:50, 13 June 2012
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	The entry 4fe2 is ON HOLD		The entry 4fe2 is ON HOLD

	Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L. M.-W.		Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L.M.-W.

	Description: X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+		Description: X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+

OCA: Protected "4fe2" [edit=sysop:move=sysop]

2012-06-06T07:22:43Z

Protected "4fe2" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:22, 6 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4fe2 is ON HOLD Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L. M.-W. Description: X-Ray Structure of SAICAR Synthetase (PurC) from S...

2012-06-06T07:22:42Z

New page: '''Unreleased structure''' The entry 4fe2 is ON HOLD Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L. M.-W. Description: X-Ray Structure of SAICAR Synthetase (PurC) from S...

New page

'''Unreleased structure'''

The entry 4fe2 is ON HOLD

Authors: Wolf, N., Abad-Zapatero, C., Johnson, M.E., Fung, L. M.-W.

Description: X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+