4feb - Revision history

OCA at 11:15, 1 March 2024

2024-03-01T11:15:33Z

← Older revision		Revision as of 11:15, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [https://pdbe.org/4feb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [https://www.ebi.ac.uk/pdbsum/4feb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [https://pdbe.org/4feb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [https://www.ebi.ac.uk/pdbsum/4feb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] May play a role in microtubule-mediated transport or vesicle function.[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).		[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] May play a role in microtubule-mediated transport or vesicle function.[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Huntington disease is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine (polyQ) expansion (> 35Q) in the first exon (EX1) of huntingtin protein (Htt). mHtt protein is thought to adopt one or more toxic conformation(s) that are involved in pathogenic interactions in cells . However, the structure of mHtt is not known. Here, we present a near atomic resolution structure of mHtt36Q-EX1. To facilitate crystallization, three histidine residues (3H) were introduced within the Htt36Q stretch resulting in the sequence of Q 7HQHQHQ 27. The Htt36Q3H region adopts alpha-helix, loop, beta-hairpin conformations. Furthermore, we observed interactions between the backbone of the Htt36Q3H beta-strand with the aromatic residues mimicking putative-toxic interactions with other proteins. Our findings support previous predictions that the expanded mHtt-polyQ region adopts a beta-sheet structure. Detailed structural information about mHtt improves our understanding of the pathogenic mechanisms in HD and other polyQ expansion disorders and may form the basis for rational design of small molecules that target toxic conformations of disease-causing proteins.

	Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.,Kim M Prion. 2013 Jan 31;7(3). PMID:23370273<ref>PMID:23370273</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Huntingtin\|Huntingtin]]		*[[Huntingtin\|Huntingtin]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:42, 16 November 2022

2022-11-16T20:42:32Z

← Older revision		Revision as of 20:42, 16 November 2022
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	<StructureSection load='4feb' size='340' side='right'caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4feb' size='340' side='right'caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [https://pdbe.org/4feb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [https://www.ebi.ac.uk/pdbsum/4feb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [~~http~~://pdbe.org/4feb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4feb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] Juvenile Huntington disease;Huntington disease. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).		[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] May play a role in microtubule-mediated transport or vesicle function.[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Escherichia coli O157:H7]]
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kim, M]]		[[Category: Kim M]]
	~~[[Category: Alpha helix]]~~
	~~[[Category: Beta strand hairpin]]~~
	~~[[Category: Beta-strand hairpin]]~~
	~~[[Category: Disease protein]]~~
	~~[[Category: Loop]]~~
	~~[[Category: Signaling protein~~]]

OCA at 09:52, 5 February 2020

2020-02-05T09:52:41Z

← Older revision		Revision as of 09:52, 5 February 2020
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	==Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)==		==Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)==
	<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4feb' size='340' side='right'caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEB FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Huntingtin\|Huntingtin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Kim, M]]		[[Category: Kim, M]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]

OCA at 11:11, 16 November 2017

2017-11-16T11:11:54Z

← Older revision		Revision as of 11:11, 16 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Huntingtin\|Huntingtin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:40, 3 August 2017

2017-08-03T09:40:39Z

← Older revision		Revision as of 09:40, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, HD, HTT, IT15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://pdbe.org/4feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://pdbe.org/4feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~MALE_ECOLI MALE_ECOLI~~]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Huntingtin\|Huntingtin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Kim, M]]		[[Category: Kim, M]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]

OCA at 06:14, 5 August 2016

2016-08-05T06:14:24Z

← Older revision		Revision as of 06:14, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)==		==Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)==
	<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, HD, HTT, IT15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, HD, HTT, IT15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://pdbe.org/4feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4feb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4feb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:26, 25 December 2014

2014-12-25T16:26:11Z

← Older revision		Revision as of 16:26, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:38, 21 December 2014

2014-12-21T11:38:28Z

← Older revision		Revision as of 11:38, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4feb\| PDB=4feb \| SCENE= }}~~		==Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)==
	===Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)===		<StructureSection load='4feb' size='340' side='right' caption='[[4feb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_23370273}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4feb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FEB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3io4\|3io4]], [[3io6\|3io6]], [[3iot\|3iot]], [[3iou\|3iou]], [[3ior\|3ior]], [[3iov\|3iov]], [[4fe8\|4fe8]], [[4fec\|4fec]], [[4fed\|4fed]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, HD, HTT, IT15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4feb RCSB], [http://www.ebi.ac.uk/pdbsum/4feb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Huntington disease is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine (polyQ) expansion (> 35Q) in the first exon (EX1) of huntingtin protein (Htt). mHtt protein is thought to adopt one or more toxic conformation(s) that are involved in pathogenic interactions in cells . However, the structure of mHtt is not known. Here, we present a near atomic resolution structure of mHtt36Q-EX1. To facilitate crystallization, three histidine residues (3H) were introduced within the Htt36Q stretch resulting in the sequence of Q 7HQHQHQ 27. The Htt36Q3H region adopts alpha-helix, loop, beta-hairpin conformations. Furthermore, we observed interactions between the backbone of the Htt36Q3H beta-strand with the aromatic residues mimicking putative-toxic interactions with other proteins. Our findings support previous predictions that the expanded mHtt-polyQ region adopts a beta-sheet structure. Detailed structural information about mHtt improves our understanding of the pathogenic mechanisms in HD and other polyQ expansion disorders and may form the basis for rational design of small molecules that target toxic conformations of disease-causing proteins.

	~~==Function==~~		Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.,Kim M Prion. 2013 Jan 31;7(3). PMID:23370273<ref>PMID:23370273</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot~~/~~MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4feb]] is~~ a ~~3 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4FEB OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023370273</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
	[[Category: Kim, M.]]		</StructureSection>
			[[Category: Human]]
			[[Category: Kim, M]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Beta strand hairpin]]		[[Category: Beta strand hairpin]]

OCA at 11:57, 3 July 2013

2013-07-03T11:57:59Z

← Older revision		Revision as of 11:57, 3 July 2013
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	===Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)===		===Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)===
	{{ABSTRACT_PUBMED_23370273}}		{{ABSTRACT_PUBMED_23370273}}

			==Function==
			[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.

	==About this Structure==		==About this Structure==
	[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA].		[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA].

			==Reference==
			<ref group="xtra">PMID:023370273</ref><references group="xtra"/><references/>
	[[Category: Kim, M.]]		[[Category: Kim, M.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]

OCA at 10:19, 13 March 2013

2013-03-13T10:19:48Z

← Older revision		Revision as of 10:19, 13 March 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4feb\| PDB=4feb \| SCENE= }}
			===Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)===
			{{ABSTRACT_PUBMED_23370273}}

	~~The entry~~ 4feb is ~~ON HOLD~~		==About this Structure==
			[[4feb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEB OCA].
	~~Authors~~: Kim. M.		[[Category: Kim, M.]]
			[[Category: Alpha helix]]
	~~Description~~: ~~Crystal Structure of Htt36Q3H~~-~~EX1-X1-C2(Beta)~~		[[Category: Beta strand hairpin]]
			[[Category: Beta-strand hairpin]]
			[[Category: Disease protein]]
			[[Category: Loop]]
			[[Category: Signaling protein]]