4ffb - Revision history

OCA at 15:23, 14 March 2024

2024-03-14T15:23:42Z

← Older revision		Revision as of 15:23, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.882Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [https://pdbe.org/4ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [https://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [https://pdbe.org/4ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [https://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.		[https://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that use alphabeta-tubulin-interacting tumor overexpressed gene (TOG) domains to catalyze fast microtubule growth. Catalysis requires that these polymerases discriminate between unpolymerized and polymerized forms of alphabeta-tubulin, but the mechanism by which they do so has remained unclear. Here, we report the structure of the TOG1 domain from Stu2p bound to yeast alphabeta-tubulin. TOG1 binds alphabeta-tubulin in a way that excludes equivalent binding of a second TOG domain. Furthermore, TOG1 preferentially binds a curved conformation of alphabeta-tubulin that cannot be incorporated into microtubules, contacting alpha- and beta-tubulin surfaces that do not participate in microtubule assembly. Conformation-selective interactions with alphabeta-tubulin explain how TOG-containing polymerases discriminate between unpolymerized and polymerized forms of alphabeta-tubulin and how they selectively recognize the growing end of the microtubule.

	A TOG:alphabeta-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.,Ayaz P, Ye X, Huddleston P, Brautigam CA, Rice LM Science. 2012 Aug 17;337(6096):857-60. PMID:22904013<ref>PMID:22904013</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ffb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]		*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:53, 7 October 2022

2022-10-07T04:53:34Z

← Older revision		Revision as of 04:53, 7 October 2022
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	==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==		==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==
	<StructureSection load='4ffb' size='340' side='right' caption='[[4ffb]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4ffb' size='340' side='right'caption='[[4ffb]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUB1, YML085C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TUB2, YFL037W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), L2108, STU2, YLR045C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [https://pdbe.org/4ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [https://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [~~http~~://pdbe.org/4ffb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STU2_YEAST STU2_YEAST]] May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. [[http://www.uniprot.org/uniprot/TBB_YEAST TBB_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.		[https://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
	*[[Tubulin\|Tubulin]]		*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Baker's yeast~~]]		[[Category: Large Structures]]
	[[Category: ~~Tubulin GTPase~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: Ayaz, P]]		[[Category: Ayaz P]]
	[[Category: Brautigam~~, C A~~]]		[[Category: Brautigam CA]]
	[[Category: Huddleston, P]]		[[Category: Huddleston P]]
	[[Category: Rice~~, L M~~]]		[[Category: Rice LM]]
	[[Category: Ye, X]]		[[Category: Ye X]]
	~~[[Category: Cytoskeleton]]~~
	~~[[Category: Heat repeat]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Microtubule]]~~
	~~[[Category: Tog domain]]~~
	~~[[Category: Tubulin]]~~
	~~[[Category: Tubulin fold~~]]

OCA at 10:02, 5 August 2016

2016-08-05T10:02:21Z

← Older revision		Revision as of 10:02, 5 August 2016
Line 1:		Line 1:

	==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==		==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==
	<StructureSection load='4ffb' size='340' side='right' caption='[[4ffb]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4ffb' size='340' side='right' caption='[[4ffb]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUB1, YML085C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), TUB2, YFL037W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), L2108, STU2, YLR045C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUB1, YML085C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TUB2, YFL037W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), L2108, STU2, YLR045C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [http://www.ebi.ac.uk/pdbsum/4ffb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [http://pdbe.org/4ffb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [http://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ffb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae s288c~~]]		[[Category: Baker's yeast]]
	[[Category: Tubulin GTPase]]		[[Category: Tubulin GTPase]]
	[[Category: Ayaz, P]]		[[Category: Ayaz, P]]

OCA at 17:53, 25 December 2014

2014-12-25T17:53:43Z

← Older revision		Revision as of 17:53, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4ffb\| PDB=4ffb \| SCENE= }}~~		==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==
	===A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase===		<StructureSection load='4ffb' size='340' side='right' caption='[[4ffb]], [[Resolution\|resolution]] 2.88Å' scene=''>
	~~{{ABSTRACT_PUBMED_22904013}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUB1, YML085C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), TUB2, YFL037W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), L2108, STU2, YLR045C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [http://www.ebi.ac.uk/pdbsum/4ffb PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STU2_YEAST STU2_YEAST]] May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. [[http://www.uniprot.org/uniprot/TBB_YEAST TBB_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that use alphabeta-tubulin-interacting tumor overexpressed gene (TOG) domains to catalyze fast microtubule growth. Catalysis requires that these polymerases discriminate between unpolymerized and polymerized forms of alphabeta-tubulin, but the mechanism by which they do so has remained unclear. Here, we report the structure of the TOG1 domain from Stu2p bound to yeast alphabeta-tubulin. TOG1 binds alphabeta-tubulin in a way that excludes equivalent binding of a second TOG domain. Furthermore, TOG1 preferentially binds a curved conformation of alphabeta-tubulin that cannot be incorporated into microtubules, contacting alpha- and beta-tubulin surfaces that do not participate in microtubule assembly. Conformation-selective interactions with alphabeta-tubulin explain how TOG-containing polymerases discriminate between unpolymerized and polymerized forms of alphabeta-tubulin and how they selectively recognize the growing end of the microtubule.

	~~==Function==~~		A TOG:alphabeta-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.,Ayaz P, Ye X, Huddleston P, Brautigam CA, Rice LM Science. 2012 Aug 17;337(6096):857-60. PMID:22904013<ref>PMID:22904013</ref>
	~~[[http~~:~~//www~~.~~uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP~~, ~~one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STU2_YEAST STU2_YEAST]] May play a role in the attachment~~, ~~organization~~, ~~and/or dynamics of microtubule ends at the spindle pole body~~. ~~[[http~~:~~//www~~.~~uniprot.org~~/uniprot/TBB_YEAST TBB_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4ffb]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA].~~		</div>

	==See Also==		==See Also==
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:022904013</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Tubulin GTPase]]		[[Category: Tubulin GTPase]]
	[[Category: Ayaz, P.]]		[[Category: Ayaz, P]]
	[[Category: Brautigam, C A.]]		[[Category: Brautigam, C A]]
	[[Category: Huddleston, P.]]		[[Category: Huddleston, P]]
	[[Category: Rice, L M.]]		[[Category: Rice, L M]]
	[[Category: Ye, X.]]		[[Category: Ye, X]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]

OCA at 05:16, 28 August 2013

2013-08-28T05:16:41Z

← Older revision		Revision as of 05:16, 28 August 2013
Line 1:		Line 1:
	~~[[Image:4ffb.jpg\|left\|200px]]~~

	{{STRUCTURE_4ffb\| PDB=4ffb \| SCENE= }}		{{STRUCTURE_4ffb\| PDB=4ffb \| SCENE= }}

	===A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase===		===A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase===
			{{ABSTRACT_PUBMED_22904013}}

			==Function==
			[[http://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STU2_YEAST STU2_YEAST]] May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. [[http://www.uniprot.org/uniprot/TBB_YEAST TBB_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

	==About this Structure==		==About this Structure==
	[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae~~ Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA].		[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA].
	[[Category: Saccharomyces cerevisiae]]
			==See Also==
			*[[Tubulin\|Tubulin]]

			==Reference==
			<ref group="xtra">PMID:022904013</ref><references group="xtra"/><references/>
			[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Tubulin GTPase]]		[[Category: Tubulin GTPase]]
	[[Category: Ayaz, P.]]		[[Category: Ayaz, P.]]

OCA at 05:52, 15 August 2012

2012-08-15T05:52:39Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ffb.jpg|left|200px]]
-The entry 4ffb is ON HOLD  until Paper Publication
+{{STRUCTURE_4ffb|  PDB=4ffb  |  SCENE=  }}
-Authors: Ayaz, P., Ye, X., Huddleston, P., Brautigam, C.A., Rice, L.M.
+===A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase===
-Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase

OCA at 05:23, 27 June 2012

2012-06-27T05:23:51Z

← Older revision		Revision as of 05:23, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ffb is ON HOLD		The entry 4ffb is ON HOLD until Paper Publication

	Authors: Ayaz, P., Ye, X., Huddleston, P., Brautigam, C.A., Rice, L.M.		Authors: Ayaz, P., Ye, X., Huddleston, P., Brautigam, C.A., Rice, L.M.

	Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase		Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase

OCA at 07:24, 20 June 2012

2012-06-20T07:24:55Z

← Older revision		Revision as of 07:24, 20 June 2012
Line 3:		Line 3:
	The entry 4ffb is ON HOLD		The entry 4ffb is ON HOLD

	Authors: Ayaz, P, Ye, X, Huddleston, P, Brautigam, C.A., Rice, L.M.		Authors: Ayaz, P., Ye, X., Huddleston, P., Brautigam, C.A., Rice, L.M.

	Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase		Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase

OCA: Protected "4ffb" [edit=sysop:move=sysop]

2012-06-06T07:23:57Z

Protected "4ffb" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:23, 6 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ffb is ON HOLD Authors: Ayaz, P, Ye, X, Huddleston, P, Brautigam, C.A., Rice, L.M. Description: A TOG:alpha/beta-tubulin Complex Structure Reveals...

2012-06-06T07:23:56Z

New page: '''Unreleased structure''' The entry 4ffb is ON HOLD Authors: Ayaz, P, Ye, X, Huddleston, P, Brautigam, C.A., Rice, L.M. Description: A TOG:alpha/beta-tubulin Complex Structure Reveals...

New page

'''Unreleased structure'''

The entry 4ffb is ON HOLD

Authors: Ayaz, P, Ye, X, Huddleston, P, Brautigam, C.A., Rice, L.M.

Description: A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase