4ffc - Revision history

OCA at 15:23, 14 March 2024

2024-03-14T15:23:46Z

← Older revision		Revision as of 15:23, 14 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/B1MIQ9_MYCA9 B1MIQ9_MYCA9]		[https://www.uniprot.org/uniprot/B1MIQ9_MYCA9 B1MIQ9_MYCA9]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ffc" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]		*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycobacteroides abscessus ATCC 19977]]		[[Category: Mycobacteroides abscessus ATCC 19977]]

OCA at 08:22, 6 December 2023

2023-12-06T08:22:22Z

← Older revision		Revision as of 08:22, 6 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [https://pdbe.org/4ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [https://www.ebi.ac.uk/pdbsum/4ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [https://pdbe.org/4ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [https://www.ebi.ac.uk/pdbsum/4ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:53, 7 October 2022

2022-10-07T04:53:34Z

← Older revision		Revision as of 04:53, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus==		==Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus==
	<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4ffc' size='340' side='right'caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myca9 Myca9~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>~~</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [https://pdbe.org/4ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [https://www.ebi.ac.uk/pdbsum/4ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffc ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [~~http~~://pdbe.org/4ffc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ffc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/B1MIQ9_MYCA9 B1MIQ9_MYCA9]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
	*[[Aminotransferase\|Aminotransferase]]		*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Myca9~~]]		[[Category: Large Structures]]
	[[Category: ~~Structural genomic]]~~		[[Category: Mycobacteroides abscessus ATCC 19977]]
	~~[[Category: Aminotransferase]]~~
	~~[[Category: Gabt]]~~
	~~[[Category: Mycobacterium]]~~
	~~[[Category: National institute of allergy and infectious disease]]~~
	~~[[Category: Niaid]]~~
	~~[[Category: Pyridoxal phosphate binding]]~~
	~~[[Category: Ssgcid]]~~
	~~[[Category: Transferase~~]]

OCA at 17:27, 18 January 2017

2017-01-18T17:27:12Z

← Older revision		Revision as of 17:27, 18 January 2017
Line 1:		Line 1:

	==Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus==		==Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus==
	<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca9 Myca9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca9 Myca9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://pdbe.org/4ffc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ffc" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:04, 11 March 2015

2015-03-11T06:04:28Z

← Older revision		Revision as of 06:04, 11 March 2015
Line 2:		Line 2:
	<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_abscessus Mycobacterium abscessus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca9 Myca9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~36809 Mycobacterium abscessus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

			Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium abscessus~~]]		[[Category: Myca9]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 13:14, 4 January 2015

2015-01-04T13:14:33Z

← Older revision		Revision as of 13:14, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_abscessus Mycobacterium abscessus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_abscessus Mycobacterium abscessus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36809 Mycobacterium abscessus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36809 Mycobacterium abscessus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>
	<table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium abscessus]]		[[Category: Mycobacterium abscessus]]
	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]		[[Category: Structural genomic]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Gabt]]		[[Category: Gabt]]
Line 18:		Line 18:
	[[Category: Niaid]]		[[Category: Niaid]]
	[[Category: Pyridoxal phosphate binding]]		[[Category: Pyridoxal phosphate binding]]
	~~[[Category: Seattle structural genomics center for infectious disease]]~~
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:21, 5 June 2014

2014-06-05T08:21:07Z

← Older revision		Revision as of 08:21, 5 June 2014
Line 1:		Line 1:
	~~[[Image:4ffc.jpg\|left\|200px]]~~		==Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus==
			<StructureSection load='4ffc' size='340' side='right' caption='[[4ffc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~<!--~~		== Structural highlights ==
	~~The line below this paragraph, containing "STRUCTURE_4ffc", creates the "Structure Box" on the page.~~		<table><tr><td colspan='2'>[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_abscessus Mycobacterium abscessus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFC FirstGlance]. <br>
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~		<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
	~~or leave the SCENE parameter empty for the default display.~~		<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_4207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36809 Mycobacterium abscessus])</td></tr>
	~~-->~~		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ffc RCSB], [http://www.ebi.ac.uk/pdbsum/4ffc PDBsum]</span></td></tr>
	~~{{STRUCTURE_4ffc\| PDB=4ffc \| SCENE= }}~~		<table>
			__TOC__
	===Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus===		</StructureSection>


	==~~About this Structure~~==
	[[4ffc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_abscessus Mycobacterium abscessus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFC OCA].
	[[Category: Mycobacterium abscessus]]		[[Category: Mycobacterium abscessus]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 06:27, 13 June 2012

2012-06-13T06:27:28Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4ffc.jpg|left|200px]]
-The entry 4ffc is ON HOLD
+<!--
-Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
+===Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus===
-Description: Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus

OCA: Protected "4ffc" [edit=sysop:move=sysop]

2012-06-06T07:23:59Z

Protected "4ffc" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:23, 6 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ffc is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCI...

2012-06-06T07:23:58Z

New page: '''Unreleased structure''' The entry 4ffc is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCI...

New page

'''Unreleased structure'''

The entry 4ffc is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of a 4-aminobutyrate aminotransferase (GabT) from Mycobacterium abscessus