4fpc - Revision history

OCA at 11:21, 1 March 2024

2024-03-01T11:21:33Z

← Older revision		Revision as of 11:21, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FPC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.32Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [https://pdbe.org/4fpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [https://www.ebi.ac.uk/pdbsum/4fpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [https://pdbe.org/4fpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [https://www.ebi.ac.uk/pdbsum/4fpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]		[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The major human pathogen Streptococcus pneumoniae plays a key role in several disease states including septicaemia, meningitis and community-acquired pneumonia. Although vaccines against S. pneumoniae are available as prophylactics, there remains a need to identify and characterise novel chemical entities that can treat the diseases caused by this pathogen. S. pneumoniae expresses three sialidases, enzymes that cleave sialic acid from carbohydrate-based surface molecules. Two of these enzymes, NanA and NanB, have been implicated in the pathogenesis of S. pneumoniae and are considered to be validated drug targets. Here we report our studies on the synthesis and structural characterisation of novel NanB-selective inhibitors that are inspired by the beta-amino-sulfonic acid family of buffers.

	Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.,Brear P, Telford J, Taylor GL, Westwood NJ Chembiochem. 2012 Nov 5;13(16):2374-83. doi: 10.1002/cbic.201200433. Epub 2012, Oct 15. PMID:23070966<ref>PMID:23070966</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4fpc" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:04, 19 October 2022

2022-10-19T20:04:16Z

← Older revision		Revision as of 20:04, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate==		==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate==
	<StructureSection load='4fpc' size='340' side='right' caption='[[4fpc]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='4fpc' size='340' side='right'caption='[[4fpc]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FPC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vw0\|2vw0]], [[2vw1\|2vw1]], [[2vw2\|2vw2]], [[4foq\|4foq]], [[4fov\|4fov]], [[4fow\|4fow]], [[4foy\|4foy]], [[4fp2\|4fp2]], [[4fp3\|4fp3]], [[4fpe\|4fpe]], [[4fpf\|4fpf]], [[4fpg\|4fpg]], [[4fph\|4fph]], [[4fpj\|4fpj]], [[4fpk\|4fpk]], [[4fpl\|4fpl]], [[4fpo\|4fpo]], [[4fpy\|4fpy]], [[4fq4\|4fq4]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [https://pdbe.org/4fpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [https://www.ebi.ac.uk/pdbsum/4fpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpc ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [~~http~~://pdbe.org/4fpc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fpc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Exo-alpha-sialidase~~]]		[[Category: Large Structures]]
	[[Category: ~~Brear, P~~]]		[[Category: Streptococcus pneumoniae]]
	[[Category: ~~Drug design]]~~		[[Category: Brear P]]
	~~[[Category: Glycosidase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-inhibitor complex]]~~
	~~[[Category: Intramolecular trans-sialidase]]~~
	~~[[Category: Neuraminidase~~]]

OCA at 20:06, 15 December 2016

2016-12-15T20:06:00Z

← Older revision		Revision as of 20:06, 15 December 2016
Line 1:		Line 1:

	==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate==		==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate==
	<StructureSection load='4fpc' size='340' side='right' caption='[[4fpc]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='4fpc' size='340' side='right' caption='[[4fpc]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vw0\|2vw0]], [[2vw1\|2vw1]], [[2vw2\|2vw2]], [[4foq\|4foq]], [[4fov\|4fov]], [[4fow\|4fow]], [[4foy\|4foy]], [[4fp2\|4fp2]], [[4fp3\|4fp3]], [[4fpe\|4fpe]], [[4fpf\|4fpf]], [[4fpg\|4fpg]], [[4fph\|4fph]], [[4fpj\|4fpj]], [[4fpk\|4fpk]], [[4fpl\|4fpl]], [[4fpo\|4fpo]], [[4fpy\|4fpy]], [[4fq4\|4fq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vw0\|2vw0]], [[2vw1\|2vw1]], [[2vw2\|2vw2]], [[4foq\|4foq]], [[4fov\|4fov]], [[4fow\|4fow]], [[4foy\|4foy]], [[4fp2\|4fp2]], [[4fp3\|4fp3]], [[4fpe\|4fpe]], [[4fpf\|4fpf]], [[4fpg\|4fpg]], [[4fph\|4fph]], [[4fpj\|4fpj]], [[4fpk\|4fpk]], [[4fpl\|4fpl]], [[4fpo\|4fpo]], [[4fpy\|4fpy]], [[4fq4\|4fq4]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 ~~Streptococcus~~ pneumoniae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [http://www.ebi.ac.uk/pdbsum/4fpc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [http://pdbe.org/4fpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [http://www.ebi.ac.uk/pdbsum/4fpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4fpc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	~~[[Category: Streptococcus pneumoniae]]~~
	[[Category: Brear, P]]		[[Category: Brear, P]]
	[[Category: Drug design]]		[[Category: Drug design]]

OCA at 17:49, 9 December 2014

2014-12-09T17:49:30Z

← Older revision		Revision as of 17:49, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4fpc~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate==
			<StructureSection load='4fpc' size='340' side='right' caption='[[4fpc]], [[Resolution\|resolution]] 2.32Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4fpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPC FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MFY:2-[(4-CHLOROBENZYL)AMINO]ETHANESULFONIC+ACID'>MFY</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vw0\|2vw0]], [[2vw1\|2vw1]], [[2vw2\|2vw2]], [[4foq\|4foq]], [[4fov\|4fov]], [[4fow\|4fow]], [[4foy\|4foy]], [[4fp2\|4fp2]], [[4fp3\|4fp3]], [[4fpe\|4fpe]], [[4fpf\|4fpf]], [[4fpg\|4fpg]], [[4fph\|4fph]], [[4fpj\|4fpj]], [[4fpk\|4fpk]], [[4fpl\|4fpl]], [[4fpo\|4fpo]], [[4fpy\|4fpy]], [[4fq4\|4fq4]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fpc RCSB], [http://www.ebi.ac.uk/pdbsum/4fpc PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The major human pathogen Streptococcus pneumoniae plays a key role in several disease states including septicaemia, meningitis and community-acquired pneumonia. Although vaccines against S. pneumoniae are available as prophylactics, there remains a need to identify and characterise novel chemical entities that can treat the diseases caused by this pathogen. S. pneumoniae expresses three sialidases, enzymes that cleave sialic acid from carbohydrate-based surface molecules. Two of these enzymes, NanA and NanB, have been implicated in the pathogenesis of S. pneumoniae and are considered to be validated drug targets. Here we report our studies on the synthesis and structural characterisation of novel NanB-selective inhibitors that are inspired by the beta-amino-sulfonic acid family of buffers.

	~~{{STRUCTURE_4fpc\| PDB=4fpc \| SCENE= }}~~		Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.,Brear P, Telford J, Taylor GL, Westwood NJ Chembiochem. 2012 Nov 5;13(16):2374-83. doi: 10.1002/cbic.201200433. Epub 2012, Oct 15. PMID:23070966<ref>PMID:23070966</ref>

	~~===Crystal structure~~ of the ~~NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
	==~~About this Structure~~==		*[[Neuraminidase\|Neuraminidase]]
	[[~~4fpc~~]] ~~is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA].~~		== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Brear, P.]]		[[Category: Brear, P]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]

OCA at 07:13, 14 November 2012

2012-11-14T07:13:26Z

← Older revision		Revision as of 07:13, 14 November 2012
Line 1:		Line 1:
	[[Image:4fpc.~~jpg~~\|left\|200px]]		[[Image:4fpc.png\|left\|200px]]

	{{STRUCTURE_4fpc\| PDB=4fpc \| SCENE= }}		{{STRUCTURE_4fpc\| PDB=4fpc \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate===		===Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate===

	~~{{ABSTRACT_PUBMED_23070966}}~~

	==About this Structure==		==About this Structure==

OCA at 09:07, 31 October 2012

2012-10-31T09:07:14Z

← Older revision		Revision as of 09:07, 31 October 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4fpc.jpg\|left\|200px]]

	~~The entry~~ 4fpc ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4fpc\| PDB=4fpc \| SCENE= }}

	~~Authors: Brear, P.~~		===Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate===

	~~Description~~: ~~Crystal structure of the NanB~~ sialidase ~~from streptococcus~~ pneumoniae in complex ~~with 2~~-[~~(4-Chlorobenzyl)ammonio~~]~~ethanesulfonate~~		{{ABSTRACT_PUBMED_23070966}}

			==About this Structure==
			[[4fpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPC OCA].
			[[Category: Exo-alpha-sialidase]]
			[[Category: Streptococcus pneumoniae]]
			[[Category: Brear, P.]]
			[[Category: Drug design]]
			[[Category: Glycosidase]]
			[[Category: Hydrolase]]
			[[Category: Hydrolase-inhibitor complex]]
			[[Category: Intramolecular trans-sialidase]]
			[[Category: Neuraminidase]]

OCA at 07:48, 11 July 2012

2012-07-11T07:48:30Z

← Older revision		Revision as of 07:48, 11 July 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fpc is ON HOLD		The entry 4fpc is ON HOLD until Paper Publication

	Authors: Brear, P.		Authors: Brear, P.

	Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate		Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate

OCA: Protected "4fpc" [edit=sysop:move=sysop]

2012-06-27T05:29:44Z

Protected "4fpc" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:29, 27 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4fpc is ON HOLD Authors: Brear, P. Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorob...

2012-06-27T05:29:43Z

New page: '''Unreleased structure''' The entry 4fpc is ON HOLD Authors: Brear, P. Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorob...

New page

'''Unreleased structure'''

The entry 4fpc is ON HOLD

Authors: Brear, P.

Description: Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate