4fui - Revision history

OCA at 02:54, 21 November 2024

2024-11-21T02:54:35Z

← Older revision		Revision as of 02:54, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [https://pdbe.org/4fui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [https://www.ebi.ac.uk/pdbsum/4fui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fui ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [https://pdbe.org/4fui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [https://www.ebi.ac.uk/pdbsum/4fui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fui ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
	~~== Function ==~~
	~~[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.~~

	==See Also==		==See Also==
	*[[Urokinase 3D Structures\|Urokinase 3D Structures]]		*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:10, 19 October 2022

2022-10-19T20:10:44Z

← Older revision		Revision as of 20:10, 19 October 2022
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	==Crystal Structure of the Urokinase==		==Crystal Structure of the Urokinase==
	<StructureSection load='4fui' size='340' side='right' caption='[[4fui]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4fui' size='340' side='right'caption='[[4fui]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fu7\|4fu7]], [[4fu8\|4fu8]], [[4fu9\|4fu9]], [[4fub\|4fub]], [[4fuc\|4fuc]], [[4fud\|4fud]], [[4fue\|4fue]], [[4fuf\|4fuf]], [[4fug\|4fug]], [[4fuh\|4fuh]], [[4fuj\|4fuj]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [https://pdbe.org/4fui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [https://www.ebi.ac.uk/pdbsum/4fui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fui ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [~~http~~://pdbe.org/4fui PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fui PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fui ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[~~http~~://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>		[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

			==See Also==
			*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~U-plasminogen activator~~]]		[[Category: Large Structures]]
	[[Category: Giranda, V]]		[[Category: Giranda V]]
	[[Category: Kang~~, Y N~~]]		[[Category: Kang YN]]
	[[Category: Nienaber, V]]		[[Category: Nienaber V]]
	[[Category: Stuckey~~, J A]]~~		[[Category: Stuckey JA]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]

OCA at 08:21, 15 November 2017

2017-11-15T08:21:28Z

← Older revision		Revision as of 08:21, 15 November 2017
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

	~~==See Also==~~
	*[[Urokinase\|Urokinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:34, 5 August 2016

2016-08-05T21:34:43Z

← Older revision		Revision as of 21:34, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of the Urokinase==		==Crystal Structure of the Urokinase==
	<StructureSection load='4fui' size='340' side='right' caption='[[4fui]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4fui' size='340' side='right' caption='[[4fui]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fu7\|4fu7]], [[4fu8\|4fu8]], [[4fu9\|4fu9]], [[4fub\|4fub]], [[4fuc\|4fuc]], [[4fud\|4fud]], [[4fue\|4fue]], [[4fuf\|4fuf]], [[4fug\|4fug]], [[4fuh\|4fuh]], [[4fuj\|4fuj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fu7\|4fu7]], [[4fu8\|4fu8]], [[4fu9\|4fu9]], [[4fub\|4fub]], [[4fuc\|4fuc]], [[4fud\|4fud]], [[4fue\|4fue]], [[4fuf\|4fuf]], [[4fug\|4fug]], [[4fuh\|4fuh]], [[4fuj\|4fuj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [http://www.ebi.ac.uk/pdbsum/4fui PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [http://pdbe.org/4fui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [http://www.ebi.ac.uk/pdbsum/4fui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fui ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Giranda, V]]		[[Category: Giranda, V]]

OCA at 11:18, 21 December 2014

2014-12-21T11:18:34Z

← Older revision		Revision as of 11:18, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4fui~~\| ~~PDB~~=4fui \| ~~SCENE~~= }}		==Crystal Structure of the Urokinase==
	===~~Crystal Structure of the Urokinase~~===		<StructureSection load='4fui' size='340' side='right' caption='[[4fui]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUI FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fu7\|4fu7]], [[4fu8\|4fu8]], [[4fu9\|4fu9]], [[4fub\|4fub]], [[4fuc\|4fuc]], [[4fud\|4fud]], [[4fue\|4fue]], [[4fuf\|4fuf]], [[4fug\|4fug]], [[4fuh\|4fuh]], [[4fuj\|4fuj]]</td></tr>
	==Function==		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fui RCSB], [http://www.ebi.ac.uk/pdbsum/4fui PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

	~~==About this Structure==~~
	[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA].

	==See Also==		==See Also==
	*[[Urokinase\|Urokinase]]		*[[Urokinase\|Urokinase]]
			== References ==
	==~~Reference~~==		<references/>
	<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Giranda, V.]]		[[Category: Giranda, V]]
	[[Category: Kang, Y N.]]		[[Category: Kang, Y N]]
	[[Category: Nienaber, V.]]		[[Category: Nienaber, V]]
	[[Category: Stuckey, J A.]]		[[Category: Stuckey, J A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 05:51, 25 March 2013

2013-03-25T05:51:02Z

← Older revision		Revision as of 05:51, 25 March 2013
Line 1:		Line 1:
	~~[[Image:4fui.jpg\|left\|200px]]~~

	{{STRUCTURE_4fui\| PDB=4fui \| SCENE= }}		{{STRUCTURE_4fui\| PDB=4fui \| SCENE= }}
			===Crystal Structure of the Urokinase===

	===~~Crystal Structure~~ of the ~~Urokinase===~~		==Disease==
			[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

	==About this Structure==		==About this Structure==
	[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA].		[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA].

			==See Also==
			*[[Urokinase\|Urokinase]]

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]

OCA at 06:11, 22 August 2012

2012-08-22T06:11:33Z

← Older revision		Revision as of 06:11, 22 August 2012
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	~~'''Unreleased structure'''~~		[[Image:4fui.jpg\|left\|200px]]

	~~The entry~~ 4fui ~~is ON HOLD~~ ~~until Aug 22 2013~~		{{STRUCTURE_4fui\| PDB=4fui \| SCENE= }}

	~~Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.~~		===Crystal Structure of the Urokinase===

	~~Description~~: ~~Crystal Structure of the Urokinase~~
			==About this Structure==
			[[4fui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUI OCA].
			[[Category: Homo sapiens]]
			[[Category: U-plasminogen activator]]
			[[Category: Giranda, V.]]
			[[Category: Kang, Y N.]]
			[[Category: Nienaber, V.]]
			[[Category: Stuckey, J A.]]
			[[Category: Hydrolase]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:47, 25 July 2012

2012-07-25T06:47:50Z

← Older revision		Revision as of 06:47, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fui is ON HOLD until ~~Paper Publication~~		The entry 4fui is ON HOLD until Aug 22 2013

	Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.		Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.

	Description: Crystal Structure of the Urokinase		Description: Crystal Structure of the Urokinase

OCA at 05:04, 18 July 2012

2012-07-18T05:04:09Z

← Older revision		Revision as of 05:04, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4fui is ON HOLD		The entry 4fui is ON HOLD until Paper Publication

	Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.		Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.

	Description: Crystal Structure of the Urokinase		Description: Crystal Structure of the Urokinase

OCA at 07:50, 11 July 2012

2012-07-11T07:50:28Z

← Older revision		Revision as of 07:50, 11 July 2012
Line 3:		Line 3:
	The entry 4fui is ON HOLD		The entry 4fui is ON HOLD

	Authors: Kang, Y.N., Stuckey, J.A., ~~Vicki~~ Nienaber, ~~Vincent~~ Giranda		Authors: Kang, Y.N., Stuckey, J.A., Nienaber, V., Giranda, V.

	Description: Crystal Structure of the Urokinase		Description: Crystal Structure of the Urokinase