4ful - Revision history

OCA at 06:58, 27 November 2024

2024-11-27T06:58:22Z

← Older revision		Revision as of 06:58, 27 November 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.47Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [https://pdbe.org/4ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [https://www.ebi.ac.uk/pdbsum/4ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ful ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [https://pdbe.org/4ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [https://www.ebi.ac.uk/pdbsum/4ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ful ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:10, 19 October 2022

2022-10-19T20:10:48Z

← Older revision		Revision as of 20:10, 19 October 2022
Line 1:		Line 1:

	==PI3 Kinase Gamma bound to a pyrmidine inhibitor==		==PI3 Kinase Gamma bound to a pyrmidine inhibitor==
	<StructureSection load='4ful' size='340' side='right' caption='[[4ful]], [[Resolution\|resolution]] 2.47Å' scene=''>		<StructureSection load='4ful' size='340' side='right'caption='[[4ful]], [[Resolution\|resolution]] 2.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [https://pdbe.org/4ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [https://www.ebi.ac.uk/pdbsum/4ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ful ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [~~http~~://pdbe.org/4ful PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ful PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ful ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PK3CG_HUMAN PK3CG_HUMAN]] Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.<ref>PMID:7624799</ref> <ref>PMID:12163475</ref> <ref>PMID:15294162</ref> <ref>PMID:16094730</ref> <ref>PMID:21393242</ref>		[https://www.uniprot.org/uniprot/PK3CG_HUMAN PK3CG_HUMAN] Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.<ref>PMID:7624799</ref> <ref>PMID:12163475</ref> <ref>PMID:15294162</ref> <ref>PMID:16094730</ref> <ref>PMID:21393242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
	*[[Phosphoinositide 3-~~Kinases~~\|Phosphoinositide 3-~~Kinases~~]]		*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Bard, J]]		[[Category: Large Structures]]
	[[Category: Bennett~~, E M~~]]		[[Category: Bard J]]
	[[Category: Gopalsamy, A]]		[[Category: Bennett EM]]
	[[Category: Shi, M]]		[[Category: Gopalsamy A]]
	[[Category: Yu, K]]		[[Category: Shi M]]
	[[Category: Zhang~~, W G]]~~		[[Category: Yu K]]
	~~[[Category: Kinase]]~~		[[Category: Zhang WG]]
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 12:20, 4 August 2016

2016-08-04T12:20:09Z

← Older revision		Revision as of 12:20, 4 August 2016
Line 1:		Line 1:

	==PI3 Kinase Gamma bound to a pyrmidine inhibitor==		==PI3 Kinase Gamma bound to a pyrmidine inhibitor==
	<StructureSection load='4ful' size='340' side='right' caption='[[4ful]], [[Resolution\|resolution]] 2.47Å' scene=''>		<StructureSection load='4ful' size='340' side='right' caption='[[4ful]], [[Resolution\|resolution]] 2.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [http://www.ebi.ac.uk/pdbsum/4ful PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [http://pdbe.org/4ful PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [http://www.ebi.ac.uk/pdbsum/4ful PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ful ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ful" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bard, J]]		[[Category: Bard, J]]
	[[Category: Bennett, E M]]		[[Category: Bennett, E M]]

OCA at 14:26, 24 December 2014

2014-12-24T14:26:21Z

← Older revision		Revision as of 14:26, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [http://www.ebi.ac.uk/pdbsum/4ful PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [http://www.ebi.ac.uk/pdbsum/4ful PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PK3CG_HUMAN PK3CG_HUMAN]] Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.<ref>PMID:7624799</ref> <ref>PMID:12163475</ref> <ref>PMID:15294162</ref> <ref>PMID:16094730</ref> <ref>PMID:21393242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:51, 9 December 2014

2014-12-09T14:51:21Z

← Older revision		Revision as of 14:51, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ful~~.~~png~~\|~~left~~\|~~200px~~]]		==PI3 Kinase Gamma bound to a pyrmidine inhibitor==
			<StructureSection load='4ful' size='340' side='right' caption='[[4ful]], [[Resolution\|resolution]] 2.47Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ful]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FUL FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0VU:4-({4-[3-(PIPERIDIN-1-YLCARBONYL)PHENYL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE'>0VU</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ful OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ful RCSB], [http://www.ebi.ac.uk/pdbsum/4ful PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure-based optimization of this pan-kinase scaffold to improve its biochemical profile and overall kinome selectivity, including mTOR and CDK, to generate the first reported selective hSMG-1 tool compound.

	~~{{STRUCTURE_4ful\| PDB=4ful \| SCENE= }}~~		Identification of pyrimidine derivatives as hSMG-1 inhibitors.,Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41. doi: 10.1016/j.bmcl.2012.08.107., Epub 2012 Sep 7. PMID:23021994<ref>PMID:23021994</ref>

	~~===PI3 Kinase Gamma bound to~~ a ~~pyrmidine inhibitor===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23021994}}~~		==See Also==
			*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
	==~~About this Structure~~==		== References ==
	[[~~4ful~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bard, J.]]		[[Category: Bard, J]]
	[[Category: Bennett, E M.]]		[[Category: Bennett, E M]]
	[[Category: Gopalsamy, A.]]		[[Category: Gopalsamy, A]]
	[[Category: Shi, M.]]		[[Category: Shi, M]]
	[[Category: Yu, K.]]		[[Category: Yu, K]]
	[[Category: Zhang, W G.]]		[[Category: Zhang, W G]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 09:36, 31 October 2012

2012-10-31T09:36:38Z

← Older revision		Revision as of 09:36, 31 October 2012
Line 1:		Line 1:
	[[Image:4ful.~~jpg~~\|left\|200px]]		[[Image:4ful.png\|left\|200px]]

	{{STRUCTURE_4ful\| PDB=4ful \| SCENE= }}		{{STRUCTURE_4ful\| PDB=4ful \| SCENE= }}

OCA at 07:00, 17 October 2012

2012-10-17T07:00:09Z

← Older revision		Revision as of 07:00, 17 October 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4ful.jpg\|left\|200px]]

	~~The entry~~ 4ful ~~is ON HOLD~~		{{STRUCTURE_4ful\| PDB=4ful \| SCENE= }}

	~~Authors: Gopalsamy, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K.~~		===PI3 Kinase Gamma bound to a pyrmidine inhibitor===

	~~Description~~: ~~PI3~~ Kinase ~~Gamma bound to a pyrmidine~~ inhibitor		{{ABSTRACT_PUBMED_23021994}}

			==About this Structure==
			[[4ful]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FUL OCA].
			[[Category: Homo sapiens]]
			[[Category: Bard, J.]]
			[[Category: Bennett, E M.]]
			[[Category: Gopalsamy, A.]]
			[[Category: Shi, M.]]
			[[Category: Yu, K.]]
			[[Category: Zhang, W G.]]
			[[Category: Kinase]]
			[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:47, 25 July 2012

2012-07-25T06:47:56Z

← Older revision		Revision as of 06:47, 25 July 2012
Line 3:		Line 3:
	The entry 4ful is ON HOLD		The entry 4ful is ON HOLD

	Authors: ~~Gpalsamy~~, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K.		Authors: Gopalsamy, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K.

	Description: PI3 Kinase Gamma bound to a pyrmidine inhibitor		Description: PI3 Kinase Gamma bound to a pyrmidine inhibitor

OCA: Protected "4ful" [edit=sysop:move=sysop]

2012-07-04T07:23:39Z

Protected "4ful" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:23, 4 July 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ful is ON HOLD Authors: Gpalsamy, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K. Description: PI3 Kinase Gamma bound to a pyrmidine inh...

2012-07-04T07:23:39Z

New page: '''Unreleased structure''' The entry 4ful is ON HOLD Authors: Gpalsamy, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K. Description: PI3 Kinase Gamma bound to a pyrmidine inh...

New page

'''Unreleased structure'''

The entry 4ful is ON HOLD

Authors: Gpalsamy, A., Bennett, E.M., Shi, M., Zhang, W.G., Bard, J., Yu, K.

Description: PI3 Kinase Gamma bound to a pyrmidine inhibitor