4ga3 - Revision history

OCA at 15:42, 14 March 2024

2024-03-14T15:42:11Z

← Older revision		Revision as of 15:42, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [https://pdbe.org/4ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [https://pdbe.org/4ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.		[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	We synthesized 30 lipophilic bisphosphonates and tested them in malaria parasite killing (targeting parasite geranylgeranyl diphosphate synthase, GGPPS) as well in human gammadelta T cell activation (targeting human farnesyl diphosphate synthase, FPPS). Similar patterns of activity were seen in inhibiting human FPPS and Plasmodium GGPPS, with short to medium chain-length species having most activity. In cells, shorter chain-length species had low activity, due to poor membrane permeability, and longer chain length species were poor enzyme inhibitors. Optimal activity was thus seen with ~C10 side-chains, which have the best combination of enzyme inhibition and cell penetration. We also solved the crystal structure of one potent inhibitor, bound to FPPS. The results are of interest since they suggest the possibility of a combined chemo/immuno-therapeutic approach to anti-malarial development in which both direct parasite killing as well as gammadelta T cell activation can be achieved with a single compound.

	Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.,Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E ACS Med Chem Lett. 2013 Apr 11;4(4):423-427. PMID:23610597<ref>PMID:23610597</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4ga3" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]		*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:44, 26 October 2022

2022-10-26T06:44:33Z

← Older revision		Revision as of 06:44, 26 October 2022
Line 1:		Line 1:

	==Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260==		==Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260==
	<StructureSection load='4ga3' size='340' side='right' caption='[[4ga3]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='4ga3' size='340' side='right'caption='[[4ga3]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [https://pdbe.org/4ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga3 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [~~http~~://pdbe.org/4ga3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ga3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.		[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]		*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Liu, Y L~~]]		[[Category: Large Structures]]
	[[Category: ~~Oldfield, E]]~~		[[Category: Liu Y-L]]
	~~[[Category: Zhang,~~ Y]]		[[Category: Oldfield E]]
	[[Category: ~~All alpha helice~~]]		[[Category: Zhang Y]]
	[[Category: ~~Cytosol]]~~
	~~[[Category: Transferase~~]]

OCA at 11:57, 4 August 2016

2016-08-04T11:57:42Z

← Older revision		Revision as of 11:57, 4 August 2016
Line 1:		Line 1:

	==Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260==		==Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260==
	<StructureSection load='4ga3' size='340' side='right' caption='[[4ga3]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='4ga3' size='340' side='right' caption='[[4ga3]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [http://pdbe.org/4ga3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ga3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Liu, Y L]]		[[Category: Liu, Y L]]
	[[Category: Oldfield, E]]		[[Category: Oldfield, E]]

OCA at 09:05, 25 December 2014

2014-12-25T09:05:11Z

← Older revision		Revision as of 09:05, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga3 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:47, 21 December 2014

2014-12-21T11:47:50Z

← Older revision		Revision as of 11:47, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4ga3\| PDB=4ga3 \| SCENE= }}~~		==Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260==
	===Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260===		<StructureSection load='4ga3' size='340' side='right' caption='[[4ga3]], [[Resolution\|resolution]] 2.39Å' scene=''>
	~~{{ABSTRACT_PUBMED_23610597}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA3 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GA:1-BUTYL-3-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-1H-IMIDAZOL-3-IUM'>4GA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga3 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We synthesized 30 lipophilic bisphosphonates and tested them in malaria parasite killing (targeting parasite geranylgeranyl diphosphate synthase, GGPPS) as well in human gammadelta T cell activation (targeting human farnesyl diphosphate synthase, FPPS). Similar patterns of activity were seen in inhibiting human FPPS and Plasmodium GGPPS, with short to medium chain-length species having most activity. In cells, shorter chain-length species had low activity, due to poor membrane permeability, and longer chain length species were poor enzyme inhibitors. Optimal activity was thus seen with ~C10 side-chains, which have the best combination of enzyme inhibition and cell penetration. We also solved the crystal structure of one potent inhibitor, bound to FPPS. The results are of interest since they suggest the possibility of a combined chemo/immuno-therapeutic approach to anti-malarial development in which both direct parasite killing as well as gammadelta T cell activation can be achieved with a single compound.

	~~==Function==~~		Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.,Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E ACS Med Chem Lett. 2013 Apr 11;4(4):423-427. PMID:23610597<ref>PMID:23610597</ref>
	~~[[http://www~~.~~uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP)~~, ~~a precursor for several classes of essential metabolites including sterols~~, ~~dolichols~~, ~~carotenoids~~, ~~and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates~~, ~~dimethylallyl pyrophosphate~~, ~~and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate~~.

	==~~About this Structure~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[~~4ga3~~]] ~~is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA].~~		</div>

			==See Also==
			*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Liu, Y L.]]		[[Category: Liu, Y L]]
	[[Category: Oldfield, E.]]		[[Category: Oldfield, E]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y]]
	[[Category: All alpha helice]]		[[Category: All alpha helice]]
	[[Category: Cytosol]]		[[Category: Cytosol]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:45, 8 May 2013

2013-05-08T07:45:13Z

← Older revision		Revision as of 07:45, 8 May 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4ga3\| PDB=4ga3 \| SCENE= }}
			===Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260===
			{{ABSTRACT_PUBMED_23610597}}

	~~The entry 4ga3 is ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

	~~Authors~~: Liu, Y.-L., Zhang, Y.~~, Oldfield, E.~~		==About this Structure==
			[[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA].
	~~Description~~: ~~Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260~~		[[Category: Homo sapiens]]
			[[Category: Liu, Y L.]]
			[[Category: Oldfield, E.]]
			[[Category: Zhang, Y.]]
			[[Category: All alpha helice]]
			[[Category: Cytosol]]
			[[Category: Transferase]]

OCA at 04:51, 5 September 2012

2012-09-05T04:51:42Z

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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ga3 is ON HOLD		The entry 4ga3 is ON HOLD until Paper Publication

	Authors: Liu, Y.-L., Zhang, Y., Oldfield, E.		Authors: Liu, Y.-L., Zhang, Y., Oldfield, E.

	Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260		Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260

OCA at 05:32, 22 August 2012

2012-08-22T05:32:09Z

← Older revision		Revision as of 05:32, 22 August 2012
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	The entry 4ga3 is ON HOLD		The entry 4ga3 is ON HOLD

	Authors: Liu,Y.-L., Zhang, Y., Oldfield, E.		Authors: Liu, Y.-L., Zhang, Y., Oldfield, E.

	Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260		Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260

OCA: Protected "4ga3" [edit=sysop:move=sysop]

2012-08-01T05:32:25Z

Protected "4ga3" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:32, 1 August 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ga3 is ON HOLD Authors: Liu,Y.-L., Zhang, Y., Oldfield, E. Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with B...

2012-08-01T05:32:24Z

New page: '''Unreleased structure''' The entry 4ga3 is ON HOLD Authors: Liu,Y.-L., Zhang, Y., Oldfield, E. Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with B...

New page

'''Unreleased structure'''

The entry 4ga3 is ON HOLD

Authors: Liu,Y.-L., Zhang, Y., Oldfield, E.

Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260