4gex - Revision history

OCA at 06:59, 27 November 2024

2024-11-27T06:59:24Z

← Older revision		Revision as of 06:59, 27 November 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [https://pdbe.org/4gex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [https://www.ebi.ac.uk/pdbsum/4gex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gex ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [https://pdbe.org/4gex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [https://www.ebi.ac.uk/pdbsum/4gex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gex ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:53, 26 October 2022

2022-10-26T06:53:13Z

← Older revision		Revision as of 06:53, 26 October 2022
Line 1:		Line 1:

	==Structure of a stabilised ceSAS-6 dimer, second crystal form==		==Structure of a stabilised ceSAS-6 dimer, second crystal form==
	<StructureSection load='4gex' size='340' side='right' caption='[[4gex]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4gex' size='340' side='right'caption='[[4gex]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y3v\|2y3v]], [[2y3w\|2y3w]], [[3pyi\|3pyi]], [[3q0y\|3q0y]], [[3q0x\|3q0x]], [[4g79\|4g79]], [[4geu\|4geu]], [[4gfa\|4gfa]], [[4gfc\|4gfc]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [https://pdbe.org/4gex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [https://www.ebi.ac.uk/pdbsum/4gex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gex ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-6, Y45F10D.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [~~http~~://pdbe.org/4gex PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gex PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gex ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SAS6_CAEEL SAS6_CAEEL]] Required for centrosome duplication. Participates in centriole assembly.<ref>PMID:15572125</ref> <ref>PMID:15665853</ref>		[https://www.uniprot.org/uniprot/SAS6_CAEEL SAS6_CAEEL] Required for centrosome duplication. Participates in centriole assembly.<ref>PMID:15572125</ref> <ref>PMID:15665853</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Caeel~~]]		[[Category: Caenorhabditis elegans]]
	[[Category: ~~Erat, M C~~]]		[[Category: Large Structures]]
	[[Category: ~~Vakonakis, I~~]]		[[Category: Erat MC]]
	[[Category: ~~Alpha-beta protein]]~~		[[Category: Vakonakis I]]
	~~[[Category: Beta-sandwich]]~~
	~~[[Category: Central tube]]~~
	~~[[Category: Centriolar]]~~
	~~[[Category: Cytoplasmic]]~~
	~~[[Category: Structural protein~~]]

OCA at 17:58, 5 August 2016

2016-08-05T17:58:56Z

← Older revision		Revision as of 17:58, 5 August 2016
Line 1:		Line 1:

	==Structure of a stabilised ceSAS-6 dimer, second crystal form==		==Structure of a stabilised ceSAS-6 dimer, second crystal form==
	<StructureSection load='4gex' size='340' side='right' caption='[[4gex]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4gex' size='340' side='right' caption='[[4gex]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caenorhabditis_elegans Caenorhabditis elegans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y3v\|2y3v]], [[2y3w\|2y3w]], [[3pyi\|3pyi]], [[3q0y\|3q0y]], [[3q0x\|3q0x]], [[4g79\|4g79]], [[4geu\|4geu]], [[4gfa\|4gfa]], [[4gfc\|4gfc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y3v\|2y3v]], [[2y3w\|2y3w]], [[3pyi\|3pyi]], [[3q0y\|3q0y]], [[3q0x\|3q0x]], [[4g79\|4g79]], [[4geu\|4geu]], [[4gfa\|4gfa]], [[4gfc\|4gfc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-6, Y45F10D.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 ~~Caenorhabditis elegans~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-6, Y45F10D.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [http://www.ebi.ac.uk/pdbsum/4gex PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [http://pdbe.org/4gex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [http://www.ebi.ac.uk/pdbsum/4gex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gex ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4gex" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Caenorhabditis elegans~~]]		[[Category: Caeel]]
	[[Category: Erat, M C]]		[[Category: Erat, M C]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]

OCA at 20:48, 25 December 2014

2014-12-25T20:48:25Z

← Older revision		Revision as of 20:48, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4gex\| PDB=4gex \| SCENE= }}~~		==Structure of a stabilised ceSAS-6 dimer, second crystal form==
	===Structure of a stabilised ceSAS-6 dimer, second crystal form===		<StructureSection load='4gex' size='340' side='right' caption='[[4gex]], [[Resolution\|resolution]] 2.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_23798409}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4gex]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GEX FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y3v\|2y3v]], [[2y3w\|2y3w]], [[3pyi\|3pyi]], [[3q0y\|3q0y]], [[3q0x\|3q0x]], [[4g79\|4g79]], [[4geu\|4geu]], [[4gfa\|4gfa]], [[4gfc\|4gfc]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-6, Y45F10D.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gex RCSB], [http://www.ebi.ac.uk/pdbsum/4gex PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/SAS6_CAEEL SAS6_CAEEL]] Required for centrosome duplication. Participates in centriole assembly.<ref>PMID:15572125</ref> <ref>PMID:15665853</ref>		[[http://www.uniprot.org/uniprot/SAS6_CAEEL SAS6_CAEEL]] Required for centrosome duplication. Participates in centriole assembly.<ref>PMID:15572125</ref> <ref>PMID:15665853</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas reinhardtii and Danio rerio was shown to form ninefold symmetric, ring-shaped oligomers in vitro that were similar to the cartwheels observed in vivo during early steps of centriole assembly in most species. Here, we report crystallographic and EM analyses showing that, instead, Caenorhabotis elegans SAS-6 self-assembles into a spiral arrangement. Remarkably, we find that this spiral arrangement is also consistent with ninefold symmetry, suggesting that two distinct SAS-6 oligomerization architectures can direct the same output symmetry. Sequence analysis suggests that SAS-6 spirals are restricted to specific nematodes. This oligomeric arrangement may provide a structural basis for the presence of a central tube instead of a cartwheel during centriole assembly in these species.

	~~==About this Structure==~~		Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.,Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Fluckiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gonczy P, Vakonakis I Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11373-8. doi:, 10.1073/pnas.1302721110. Epub 2013 Jun 24. PMID:23798409<ref>PMID:23798409</ref>
	~~[[4gex]]~~ is a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4GEX OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023798409</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Erat, M C.]]		[[Category: Erat, M C]]
	[[Category: Vakonakis, I.]]		[[Category: Vakonakis, I]]
	[[Category: Alpha-beta protein]]		[[Category: Alpha-beta protein]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]

OCA at 04:32, 18 July 2013

2013-07-18T04:32:26Z

← Older revision		Revision as of 04:32, 18 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4gex\| PDB=4gex \| SCENE= }}		{{STRUCTURE_4gex\| PDB=4gex \| SCENE= }}
	===Structure of a stabilised ceSAS-6 dimer, second crystal form===		===Structure of a stabilised ceSAS-6 dimer, second crystal form===
			{{ABSTRACT_PUBMED_23798409}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:023798409</ref><references group="xtra"/><references/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Erat, M C.]]		[[Category: Erat, M C.]]

OCA at 07:22, 20 June 2013

2013-06-20T07:22:48Z

← Older revision		Revision as of 07:22, 20 June 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4gex\| PDB=4gex \| SCENE= }}
			===Structure of a stabilised ceSAS-6 dimer, second crystal form===

	~~The entry 4gex is ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/SAS6_CAEEL SAS6_CAEEL]] Required for centrosome duplication. Participates in centriole assembly.<ref>PMID:15572125</ref> <ref>PMID:15665853</ref>

	~~Authors~~: ~~Erat, M~~.C.~~, Vakonakis, I~~.		==About this Structure==
			[[4gex]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEX OCA].

	~~Description~~: ~~Structure of a stabilised ceSAS~~-~~6 dimer, second crystal form~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Caenorhabditis elegans]]
			[[Category: Erat, M C.]]
			[[Category: Vakonakis, I.]]
			[[Category: Alpha-beta protein]]
			[[Category: Beta-sandwich]]
			[[Category: Central tube]]
			[[Category: Centriolar]]
			[[Category: Cytoplasmic]]
			[[Category: Structural protein]]

OCA at 09:00, 21 November 2012

2012-11-21T09:00:26Z

← Older revision		Revision as of 09:00, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4gex is ON HOLD		The entry 4gex is ON HOLD until Paper Publication

	Authors: Erat, M.C., Vakonakis, I.		Authors: Erat, M.C., Vakonakis, I.

	Description: Structure of a stabilised ceSAS-6 dimer, second crystal form		Description: Structure of a stabilised ceSAS-6 dimer, second crystal form

OCA at 05:33, 22 August 2012

2012-08-22T05:33:52Z

← Older revision		Revision as of 05:33, 22 August 2012
Line 3:		Line 3:
	The entry 4gex is ON HOLD		The entry 4gex is ON HOLD

	Authors: Erat, M. C., Vakonakis, I.		Authors: Erat, M.C., Vakonakis, I.

	Description: Structure of a stabilised ceSAS-6 dimer, second crystal form		Description: Structure of a stabilised ceSAS-6 dimer, second crystal form

OCA: Protected "4gex" [edit=sysop:move=sysop]

2012-08-08T05:02:49Z

Protected "4gex" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:02, 8 August 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4gex is ON HOLD Authors: Erat, M. C., Vakonakis, I. Description: Structure of a stabilised ceSAS-6 dimer, second crystal form

2012-08-08T05:02:48Z

New page: '''Unreleased structure''' The entry 4gex is ON HOLD Authors: Erat, M. C., Vakonakis, I. Description: Structure of a stabilised ceSAS-6 dimer, second crystal form

New page

'''Unreleased structure'''

The entry 4gex is ON HOLD

Authors: Erat, M. C., Vakonakis, I.

Description: Structure of a stabilised ceSAS-6 dimer, second crystal form