4h4e - Revision history

OCA at 11:04, 13 August 2026

2026-08-13T11:04:34Z

← Older revision		Revision as of 11:04, 13 August 2026
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4E FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G~~</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4~~</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [https://pdbe.org/4h4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [https://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [https://pdbe.org/4h4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [https://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 15:00, 20 September 2023

2023-09-20T15:00:16Z

← Older revision		Revision as of 15:00, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [https://pdbe.org/4h4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [https://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [https://pdbe.org/4h4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [https://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:58, 3 November 2022

2022-11-03T07:58:39Z

← Older revision		Revision as of 07:58, 3 November 2022
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	==IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate==		==IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate==
	<StructureSection load='4h4e' size='340' side='right' caption='[[4h4e]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4h4e' size='340' side='right'caption='[[4h4e]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4h4c\|4h4c]], [[4h4d\|4h4d]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [https://pdbe.org/4h4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [https://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [~~http~~://pdbe.org/4h4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>		[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: 4-~~hydroxy-3-methylbut-2-enyl diphosphate reductase~~]]		[[Category: Escherichia coli K-12]]
	[[Category: ~~Ecoli~~]]		[[Category: Large Structures]]
	[[Category: Bacher, A]]		[[Category: Bacher A]]
	[[Category: Eisenreich, W]]		[[Category: Eisenreich W]]
	[[Category: Groll, M]]		[[Category: Groll M]]
	[[Category: Jauch, J]]		[[Category: Jauch J]]
	[[Category: Span, I]]		[[Category: Span I]]
	~~[[Category: Iron-sulfur protein]]~~
	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~
	~~[[Category: Reductase~~]]

OCA at 12:13, 4 August 2016

2016-08-04T12:13:03Z

← Older revision		Revision as of 12:13, 4 August 2016
Line 1:		Line 1:

	==IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate==		==IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate==
	<StructureSection load='4h4e' size='340' side='right' caption='[[4h4e]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4h4e' size='340' side='right' caption='[[4h4e]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4h4c\|4h4c]], [[4h4d\|4h4d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4h4c\|4h4c]], [[4h4d\|4h4d]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://pdbe.org/4h4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4h4e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	[[Category: ~~Escherichia coli k-12~~]]		[[Category: Ecoli]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]
	[[Category: Eisenreich, W]]		[[Category: Eisenreich, W]]

OCA at 14:21, 24 December 2014

2014-12-24T14:21:54Z

← Older revision		Revision as of 14:21, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:18, 10 December 2014

2014-12-10T09:18:10Z

← Older revision		Revision as of 09:18, 10 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4h4e~~.~~png~~\|~~left~~\|~~200px~~]]		==IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate==
			<StructureSection load='4h4e' size='340' side='right' caption='[[4h4e]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4h4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H4E FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4h4c\|4h4c]], [[4h4d\|4h4d]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The iron-sulfur protein IspH catalyzes a key step in isoprenoid biosynthesis in bacteria and malaria parasites. Crystal structures of IspH complexed with three substrate analogues reveal their mode of binding and suggest new routes to inhibitor design.

	~~{{STRUCTURE_4h4e\| PDB=4h4e \| SCENE= }}~~		Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe(4) S(4) ] Protein IspH.,Span I, Wang K, Wang W, Jauch J, Eisenreich W, Bacher A, Oldfield E, Groll M Angew Chem Int Ed Engl. 2013 Jan 10. doi: 10.1002/anie.201208469. PMID:23307751<ref>PMID:23307751</ref>

	~~===IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23307751}}~~		==See Also==
			*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	==~~About this Structure~~==		== References ==
	[[~~4h4e]] is a~~ 2 ~~chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k~~-~~12 Escherichia coli k~~-12]~~. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A]]
	[[Category: Eisenreich, W.]]		[[Category: Eisenreich, W]]
	[[Category: Groll, M.]]		[[Category: Groll, M]]
	[[Category: Jauch, J.]]		[[Category: Jauch, J]]
	[[Category: Span, I.]]		[[Category: Span, I]]
	[[Category: Iron-sulfur protein]]		[[Category: Iron-sulfur protein]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 12:28, 30 January 2013

2013-01-30T12:28:37Z

← Older revision		Revision as of 12:28, 30 January 2013
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	[[Image:4h4e.~~jpg~~\|left\|200px]]		[[Image:4h4e.png\|left\|200px]]

	{{STRUCTURE_4h4e\| PDB=4h4e \| SCENE= }}		{{STRUCTURE_4h4e\| PDB=4h4e \| SCENE= }}
Line 5:		Line 5:
	===IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate===		===IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate===

			{{ABSTRACT_PUBMED_23307751}}

	==About this Structure==		==About this Structure==

OCA at 11:58, 23 January 2013

2013-01-23T11:58:59Z

← Older revision		Revision as of 11:58, 23 January 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4h4e.jpg\|left\|200px]]

	~~The entry~~ 4h4e ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4h4e\| PDB=4h4e \| SCENE= }}

	~~Authors: Span, I., Eisenreich, W., Jauch, J., Bacher, A., Groll, M.~~		===IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate===

	~~Description~~: ~~IspH in complex with (E)~~-4-~~mercapto~~-3-methylbut-2-enyl diphosphate
			==About this Structure==
			[[4h4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4E OCA].
			[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
			[[Category: Escherichia coli k-12]]
			[[Category: Bacher, A.]]
			[[Category: Eisenreich, W.]]
			[[Category: Groll, M.]]
			[[Category: Jauch, J.]]
			[[Category: Span, I.]]
			[[Category: Iron-sulfur protein]]
			[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
			[[Category: Reductase]]

OCA at 05:47, 3 October 2012

2012-10-03T05:47:33Z

← Older revision		Revision as of 05:47, 3 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4h4e is ON HOLD		The entry 4h4e is ON HOLD until Paper Publication

	Authors: Span, I., Eisenreich, W., Jauch, J., Bacher, A., Groll, M.		Authors: Span, I., Eisenreich, W., Jauch, J., Bacher, A., Groll, M.

	Description: IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate		Description: IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate

OCA: Protected "4h4e" [edit=sysop:move=sysop]

2012-09-26T20:12:07Z

Protected "4h4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:12, 26 September 2012
(No difference)