4htm - Revision history

OCA at 11:44, 1 March 2024

2024-03-01T11:44:30Z

← Older revision		Revision as of 11:44, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [https://pdbe.org/4htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [https://www.ebi.ac.uk/pdbsum/4htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [https://pdbe.org/4htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [https://www.ebi.ac.uk/pdbsum/4htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:13, 9 November 2022

2022-11-09T08:13:32Z

← Older revision		Revision as of 08:13, 9 November 2022
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	<StructureSection load='4htm' size='340' side='right'caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4htm' size='340' side='right'caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [~~http~~://pdbe.org/4htm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4htm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [https://pdbe.org/4htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [https://www.ebi.ac.uk/pdbsum/4htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CRTC2_HUMAN CRTC2_HUMAN]] Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).<ref>PMID:14506290</ref> <ref>PMID:14536081</ref> <ref>PMID:15454081</ref> <ref>PMID:16809310</ref> <ref>PMID:16817901</ref> <ref>PMID:16980408</ref> <ref>PMID:17210223</ref>		[https://www.uniprot.org/uniprot/CRTC2_HUMAN CRTC2_HUMAN] Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).<ref>PMID:14506290</ref> <ref>PMID:14536081</ref> <ref>PMID:15454081</ref> <ref>PMID:16809310</ref> <ref>PMID:16817901</ref> <ref>PMID:16980408</ref> <ref>PMID:17210223</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kumar~~, G S~~]]		[[Category: Kumar GS]]
	[[Category: Luo, Q]]		[[Category: Luo Q]]
	[[Category: Mayo, K]]		[[Category: Mayo K]]
	[[Category: Montminy, M]]		[[Category: Montminy M]]
	[[Category: Radhakrishnan, I]]		[[Category: Radhakrishnan I]]
	[[Category: Talai, A]]		[[Category: Talai A]]
	[[Category: Tsai, W W]]		[[Category: Tsai W-W]]
	[[Category: Urday-Zaa~~, J C~~]]		[[Category: Urday-Zaa JC]]
	[[Category: Viste, K]]		[[Category: Viste K]]
	~~[[Category: Alpha-helix]]~~
	~~[[Category: Creb]]~~
	~~[[Category: Creb binding]]~~
	~~[[Category: Protein binding~~]]

OCA at 07:53, 27 March 2019

2019-03-27T07:53:52Z

← Older revision		Revision as of 07:53, 27 March 2019
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	==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==		==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==
	<StructureSection load='4htm' size='340' side='right' caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4htm' size='340' side='right'caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Kumar, G S]]		[[Category: Kumar, G S]]
	[[Category: Luo, Q]]		[[Category: Luo, Q]]

OCA at 00:35, 5 August 2016

2016-08-05T00:35:31Z

← Older revision		Revision as of 00:35, 5 August 2016
Line 1:		Line 1:

	==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==		==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==
	<StructureSection load='4htm' size='340' side='right' caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4htm' size='340' side='right' caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [http://www.ebi.ac.uk/pdbsum/4htm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [http://pdbe.org/4htm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [http://www.ebi.ac.uk/pdbsum/4htm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:24, 25 December 2014

2014-12-25T14:24:54Z

← Older revision		Revision as of 14:24, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [http://www.ebi.ac.uk/pdbsum/4htm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [http://www.ebi.ac.uk/pdbsum/4htm PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CRTC2_HUMAN CRTC2_HUMAN]] Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).<ref>PMID:14506290</ref> <ref>PMID:14536081</ref> <ref>PMID:15454081</ref> <ref>PMID:16809310</ref> <ref>PMID:16817901</ref> <ref>PMID:16980408</ref> <ref>PMID:17210223</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:09, 10 December 2014

2014-12-10T09:09:05Z

← Older revision		Revision as of 09:09, 10 December 2014
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	~~[[Image:4htm.jpg\|left\|200px]]~~		==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==
			<StructureSection load='4htm' size='340' side='right' caption='[[4htm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~{{STRUCTURE_4htm\| PDB=4htm \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
	===Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [http://www.ebi.ac.uk/pdbsum/4htm PDBsum]</span></td></tr>
			</table>
	==~~About this Structure~~==		__TOC__
	[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA].		</StructureSection>
	[[Category: Kumar, G S.]]		[[Category: Kumar, G S]]
	[[Category: Luo, Q.]]		[[Category: Luo, Q]]
	[[Category: Mayo, K.]]		[[Category: Mayo, K]]
	[[Category: Montminy, M.]]		[[Category: Montminy, M]]
	[[Category: Radhakrishnan, I.]]		[[Category: Radhakrishnan, I]]
	[[Category: Talai, A.]]		[[Category: Talai, A]]
	[[Category: Tsai, W W.]]		[[Category: Tsai, W W]]
	[[Category: Urday-Zaa, J C.]]		[[Category: Urday-Zaa, J C]]
	[[Category: Viste, K.]]		[[Category: Viste, K]]
	[[Category: Alpha-helix]]		[[Category: Alpha-helix]]
	[[Category: Creb]]		[[Category: Creb]]
	[[Category: Creb binding]]		[[Category: Creb binding]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 11:02, 5 December 2012

2012-12-05T11:02:10Z

← Older revision		Revision as of 11:02, 5 December 2012
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:4htm.jpg\|left\|200px]]

	~~The entry~~ 4htm ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4htm\| PDB=4htm \| SCENE= }}

	~~Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I.~~		===Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2===

	~~Description~~: ~~Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2~~
			==About this Structure==
			[[4htm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA].
			[[Category: Kumar, G S.]]
			[[Category: Luo, Q.]]
			[[Category: Mayo, K.]]
			[[Category: Montminy, M.]]
			[[Category: Radhakrishnan, I.]]
			[[Category: Talai, A.]]
			[[Category: Tsai, W W.]]
			[[Category: Urday-Zaa, J C.]]
			[[Category: Viste, K.]]
			[[Category: Alpha-helix]]
			[[Category: Creb]]
			[[Category: Creb binding]]
			[[Category: Protein binding]]

OCA at 09:06, 21 November 2012

2012-11-21T09:06:56Z

← Older revision		Revision as of 09:06, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4htm is ON HOLD		The entry 4htm is ON HOLD until Paper Publication

	Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I.		Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I.

	Description: Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2		Description: Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2

OCA: Protected "4htm" [edit=sysop:move=sysop]

2012-11-08T13:27:37Z

Protected "4htm" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:27, 8 November 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4htm is ON HOLD Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I. Descri...

2012-11-08T13:27:36Z

New page: '''Unreleased structure''' The entry 4htm is ON HOLD Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I. Descri...

New page

'''Unreleased structure'''

The entry 4htm is ON HOLD

Authors: Luo, Q., Viste, K., Urday-Zaa, J.C., Kumar, G.S., Tsai, W.-W., Talai, A., Mayo, K., Montminy, M., Radhakrishnan, I.

Description: Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2