4imo - Revision history

OCA at 15:25, 20 September 2023

2023-09-20T15:25:54Z

← Older revision		Revision as of 15:25, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [https://pdbe.org/4imo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [https://www.ebi.ac.uk/pdbsum/4imo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [https://pdbe.org/4imo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [https://www.ebi.ac.uk/pdbsum/4imo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:56, 16 November 2022

2022-11-16T20:56:16Z

← Older revision		Revision as of 20:56, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069==		==Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069==
	<StructureSection load='4imo' size='340' side='right' caption='[[4imo]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4imo' size='340' side='right'caption='[[4imo]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4imn\|4imn]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [https://pdbe.org/4imo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [https://www.ebi.ac.uk/pdbsum/4imo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDS, PTGDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [~~http~~://pdbe.org/4imo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4imo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>		[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
			*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Prostaglandin-D synthase~~]]		[[Category: Large Structures]]
	[[Category: Chen, D]]		[[Category: Chen D]]
	[[Category: Lim~~, S M~~]]		[[Category: Lim SM]]
	[[Category: Nordlund, P]]		[[Category: Nordlund P]]
	[[Category: Nyman, T]]		[[Category: Nyman T]]
	[[Category: Pervushin, K]]		[[Category: Pervushin K]]
	[[Category: Roos, A]]		[[Category: Roos A]]
	[[Category: Teo, H]]		[[Category: Teo H]]
	[[Category: Tresaugues, L]]		[[Category: Tresaugues L]]
	~~[[Category: Beta barrel]]~~
	~~[[Category: Endoplasmic reticulum]]~~
	~~[[Category: Isomerase~~]]

OCA at 07:20, 5 August 2016

2016-08-05T07:20:08Z

← Older revision		Revision as of 07:20, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069==		==Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069==
	<StructureSection load='4imo' size='340' side='right' caption='[[4imo]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4imo' size='340' side='right' caption='[[4imo]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4imn\|4imn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4imn\|4imn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDS, PTGDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDS, PTGDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [http://www.ebi.ac.uk/pdbsum/4imo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [http://pdbe.org/4imo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [http://www.ebi.ac.uk/pdbsum/4imo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4imo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4imo" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Glutathione S-transferase\|Glutathione S-transferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
	[[Category: Chen, D]]		[[Category: Chen, D]]

OCA at 16:49, 25 December 2014

2014-12-25T16:49:20Z

← Older revision		Revision as of 16:49, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4imo\| PDB=4imo \| SCENE= }}~~		==Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069==
	===Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069===		<StructureSection load='4imo' size='340' side='right' caption='[[4imo]], [[Resolution\|resolution]] 1.88Å' scene=''>
	{~~{ABSTRACT_PUBMED_23526831}~~}		== Structural highlights ==
			<table><tr><td colspan='2'>[[4imo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMO FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWZ:(5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC+ACID'>PWZ</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4imn\|4imn]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDS, PTGDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imo RCSB], [http://www.ebi.ac.uk/pdbsum/4imo PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>		[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Lipocalin prostaglandin D synthase (L-PGDS) regulates synthesis of an important inflammatory and signaling mediator, prostaglandin D2 (PGD2). Here, we used structural, biophysical, and biochemical approaches to address the mechanistic aspects of substrate entry, catalysis, and product exit of this enzyme. Structure of human L-PGDS was solved in a complex with a substrate analog (SA) and in ligand-free form. Its catalytic Cys 65 thiol group was found in two different conformations, each making a distinct hydrogen bond network to neighboring residues. These help in elucidating the mechanism of the cysteine nucleophile activation. Electron density for ligand observed in the active site defined the substrate binding regions, but did not allow unambiguous fitting of the SA. To further understand ligand binding, we used NMR spectroscopy to map the binding sites and to show the dynamics of protein-substrate and protein-product interactions. A model for ligand binding at the catalytic site is proposed, showing a second binding site involved in ligand exit and entry. NMR chemical shift perturbations and NMR resonance line-width alterations (observed as changes of intensity in two-dimensional cross-peaks in [(1)H,(15)N]-transfer relaxation optimization spectroscopy) for residues at the Omega loop (A-B loop), E-F loop, and G-H loop besides the catalytic sites indicate involvement of these residues in ligand entry/egress.

	~~==About this Structure==~~		Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.,Lim SM, Chen D, Teo H, Roos A, Jansson AE, Nyman T, Tresaugues L, Pervushin K, Nordlund P J Lipid Res. 2013 Jun;54(6):1630-43. doi: 10.1194/jlr.M035410. Epub 2013 Mar 22. PMID:23526831<ref>PMID:23526831</ref>
	~~[[4imo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4IMO OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023526831</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
	[[Category: Chen, D.]]		[[Category: Chen, D]]
	[[Category: Lim, S M.]]		[[Category: Lim, S M]]
	[[Category: Nordlund, P.]]		[[Category: Nordlund, P]]
	[[Category: Nyman, T.]]		[[Category: Nyman, T]]
	[[Category: Pervushin, K.]]		[[Category: Pervushin, K]]
	[[Category: Roos, A.]]		[[Category: Roos, A]]
	[[Category: Teo, H.]]		[[Category: Teo, H]]
	[[Category: Tresaugues, L.]]		[[Category: Tresaugues, L]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 15:49, 19 June 2013

2013-06-19T15:49:22Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4imo|  PDB=4imo  |  SCENE=  }}
-The entry 4imo is ON HOLD  until Paper Publication
+==Function==
-Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.
+==About this Structure==
-Description: Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069
+==Reference==

OCA at 11:11, 23 January 2013

2013-01-23T11:11:35Z

← Older revision		Revision as of 11:11, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4imo is ON HOLD		The entry 4imo is ON HOLD until Paper Publication

	Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.		Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.

	Description: Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069		Description: Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069

OCA: Protected "4imo" [edit=sysop:move=sysop]

2013-01-09T07:53:06Z

Protected "4imo" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:53, 9 January 2013
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OCA: New page: '''Unreleased structure''' The entry 4imo is ON HOLD Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P. Description: Crystal struct...

2013-01-09T07:53:04Z

New page: '''Unreleased structure''' The entry 4imo is ON HOLD Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P. Description: Crystal struct...

New page

'''Unreleased structure'''

The entry 4imo is ON HOLD

Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.

Description: Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069