4imp - Revision history

OCA at 15:25, 20 September 2023

2023-09-20T15:25:58Z

← Older revision		Revision as of 15:25, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_spinosa Saccharopolyspora spinosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_spinosa Saccharopolyspora spinosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.57Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [https://pdbe.org/4imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [https://www.ebi.ac.uk/pdbsum/4imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [https://pdbe.org/4imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [https://www.ebi.ac.uk/pdbsum/4imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:56, 16 November 2022

2022-11-16T20:56:20Z

← Older revision		Revision as of 20:56, 16 November 2022
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	==The missing linker: a dimerization motif located within polyketide synthase modules==		==The missing linker: a dimerization motif located within polyketide synthase modules==
	<StructureSection load='4imp' size='340' side='right' caption='[[4imp]], [[Resolution\|resolution]] 2.57Å' scene=''>		<StructureSection load='4imp' size='340' side='right'caption='[[4imp]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_49460 Atcc 49460~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_spinosa Saccharopolyspora spinosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spnC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=60894 ATCC 49460])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [https://pdbe.org/4imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [https://www.ebi.ac.uk/pdbsum/4imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imp ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [~~http~~://pdbe.org/4imp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4imp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4imp ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9ALM4_SACSN Q9ALM4_SACSN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 49460~~]]		[[Category: Large Structures]]
	[[Category: ~~Keatinge-Clay, A T~~]]		[[Category: Saccharopolyspora spinosa]]
	[[Category: ~~Zheng, J~~]]		[[Category: Keatinge-Clay AT]]
	[[Category: ~~Dimerization element]]~~		[[Category: Zheng J]]
	~~[[Category: Transferase~~]]

OCA at 22:16, 5 August 2016

2016-08-05T22:16:11Z

← Older revision		Revision as of 22:16, 5 August 2016
Line 1:		Line 1:

	==The missing linker: a dimerization motif located within polyketide synthase modules==		==The missing linker: a dimerization motif located within polyketide synthase modules==
	<StructureSection load='4imp' size='340' side='right' caption='[[4imp]], [[Resolution\|resolution]] 2.57Å' scene=''>		<StructureSection load='4imp' size='340' side='right' caption='[[4imp]], [[Resolution\|resolution]] 2.57Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spnC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=60894 ATCC 49460])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spnC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=60894 ATCC 49460])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [http://www.ebi.ac.uk/pdbsum/4imp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [http://pdbe.org/4imp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [http://www.ebi.ac.uk/pdbsum/4imp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4imp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4imp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:02, 21 December 2014

2014-12-21T12:02:31Z

← Older revision		Revision as of 12:02, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4imp\| PDB=4imp \| SCENE= }}~~		==The missing linker: a dimerization motif located within polyketide synthase modules==
	===The missing linker: a dimerization motif located within polyketide synthase modules===		<StructureSection load='4imp' size='340' side='right' caption='[[4imp]], [[Resolution\|resolution]] 2.57Å' scene=''>
	~~{{ABSTRACT_PUBMED_23489133}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4imp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49460 Atcc 49460]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMP FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spnC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=60894 ATCC 49460])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imp RCSB], [http://www.ebi.ac.uk/pdbsum/4imp PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The dimerization of multimodular polyketide synthases is essential for their function. Motifs that supplement the contacts made by dimeric polyketide synthase enzymes have previously been characterized outside the boundaries of modules, at the N- and C-terminal ends of polyketide synthase subunits. Here we describe a heretofore uncharacterized dimerization motif located within modules. The dimeric state of this dimerization element was elucidated through the 2.6 A resolution crystal structure of a fragment containing a dimerization element and a ketoreductase. The solution structure of a standalone dimerization element was revealed by nuclear magnetic resonance spectroscopy to be consistent with that of the crystal structure, and its dimerization constant was measured through analytical ultracentrifugation to be approximately 20 muM. The dimer buries approximately 990 A2 at its interface, and its C-terminal helices rigidly connect to ketoreductase domains to constrain their locations within a module. These structural restraints permitted the construction of a common type of polyketide synthase module.

	~~==About this Structure==~~		The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules.,Zheng J, Fage CD, Demeler B, Hoffman DW, Keatinge-Clay AT ACS Chem Biol. 2013 Mar 25. PMID:23489133<ref>PMID:23489133</ref>
	~~[[4imp]] is a 4 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Atcc_49460 Atcc 49460]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023489133</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Atcc 49460]]		[[Category: Atcc 49460]]
	[[Category: Keatinge-Clay, A T.]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Zheng, J.]]		[[Category: Zheng, J]]
	[[Category: Dimerization element]]		[[Category: Dimerization element]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:36, 20 November 2013

2013-11-20T11:36:24Z

← Older revision		Revision as of 11:36, 20 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
	[[4imp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharopolyspora_spinosa Saccharopolyspora spinosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA].		[[4imp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49460 Atcc 49460]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA].
	[[Category: ~~Saccharopolyspora spinosa~~]]
			==Reference==
			<ref group="xtra">PMID:023489133</ref><references group="xtra"/><references/>
			[[Category: Atcc 49460]]
	[[Category: Keatinge-Clay, A T.]]		[[Category: Keatinge-Clay, A T.]]
	[[Category: Zheng, J.]]		[[Category: Zheng, J.]]
	[[Category: Dimerization element]]		[[Category: Dimerization element]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:40, 27 March 2013

2013-03-27T08:40:27Z

← Older revision		Revision as of 08:40, 27 March 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_4imp\| PDB=4imp \| SCENE= }}
			===The missing linker: a dimerization motif located within polyketide synthase modules===
			{{ABSTRACT_PUBMED_23489133}}

	~~The entry~~ 4imp is ~~ON HOLD until Paper Publication~~		==About this Structure==
			[[4imp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_spinosa Saccharopolyspora spinosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMP OCA].
	~~Authors~~: ~~Zheng, J.,~~ Keatinge-Clay, A.T.		[[Category: Saccharopolyspora spinosa]]
			[[Category: Keatinge-Clay, A T.]]
	~~Description~~: ~~The missing linker~~: ~~a dimerization motif located within polyketide synthase modules~~		[[Category: Zheng, J.]]
			[[Category: Dimerization element]]
			[[Category: Transferase]]

OCA at 11:11, 23 January 2013

2013-01-23T11:11:37Z

← Older revision		Revision as of 11:11, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4imp is ON HOLD		The entry 4imp is ON HOLD until Paper Publication

	Authors: Zheng, J., Keatinge-Clay, A.T.		Authors: Zheng, J., Keatinge-Clay, A.T.

	Description: The missing linker: a dimerization motif located within polyketide synthase modules		Description: The missing linker: a dimerization motif located within polyketide synthase modules

OCA at 08:26, 16 January 2013

2013-01-16T08:26:07Z

← Older revision		Revision as of 08:26, 16 January 2013
Line 3:		Line 3:
	The entry 4imp is ON HOLD		The entry 4imp is ON HOLD

	Authors: Zheng, J, Keatinge-Clay, A.T.		Authors: Zheng, J., Keatinge-Clay, A.T.

	Description: The missing linker: a dimerization motif located within polyketide synthase modules		Description: The missing linker: a dimerization motif located within polyketide synthase modules

OCA: Protected "4imp" [edit=sysop:move=sysop]

2013-01-09T07:53:08Z

Protected "4imp" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:53, 9 January 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4imp is ON HOLD Authors: Zheng, J, Keatinge-Clay, A.T. Description: The missing linker: a dimerization motif located within polyketide synthase mod...

2013-01-09T07:53:06Z

New page: '''Unreleased structure''' The entry 4imp is ON HOLD Authors: Zheng, J, Keatinge-Clay, A.T. Description: The missing linker: a dimerization motif located within polyketide synthase mod...

New page

'''Unreleased structure'''

The entry 4imp is ON HOLD

Authors: Zheng, J, Keatinge-Clay, A.T.

Description: The missing linker: a dimerization motif located within polyketide synthase modules