4iox - Revision history

OCA at 15:28, 20 September 2023

2023-09-20T15:28:12Z

← Older revision		Revision as of 15:28, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.458Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [https://pdbe.org/4iox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [https://www.ebi.ac.uk/pdbsum/4iox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iox ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [https://pdbe.org/4iox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [https://www.ebi.ac.uk/pdbsum/4iox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iox ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:00, 16 November 2022

2022-11-16T21:00:58Z

← Older revision		Revision as of 21:00, 16 November 2022
Line 1:		Line 1:

	==The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors==		==The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors==
	<StructureSection load='4iox' size='340' side='right' caption='[[4iox]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='4iox' size='340' side='right'caption='[[4iox]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hhv-1 Hhv-~~1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [https://pdbe.org/4iox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [https://www.ebi.ac.uk/pdbsum/4iox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iox ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UL15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 HHV-1])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [~~http~~://pdbe.org/4iox PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iox PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TRM3_HHV11 TRM3_HHV11]] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.		[https://www.uniprot.org/uniprot/TRM3_HHV11 TRM3_HHV11] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Hhv-~~1]]		[[Category: Human alphaherpesvirus 1]]
	[[Category: Kamau, Y]]		[[Category: Large Structures]]
	[[Category: Sigamani, S ~~Selvarajan~~]]		[[Category: Kamau Y]]
	[[Category: Tang, L]]		[[Category: Selvarajan Sigamani S]]
	[[Category: Zhao, H]]		[[Category: Tang L]]
	~~[[Category: Nuclease]]~~		[[Category: Zhao H]]
	~~[[Category: Viral protein~~]]

OCA at 15:07, 4 August 2016

2016-08-04T15:07:35Z

← Older revision		Revision as of 15:07, 4 August 2016
Line 1:		Line 1:

	==The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors==		==The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors==
	<StructureSection load='4iox' size='340' side='right' caption='[[4iox]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='4iox' size='340' side='right' caption='[[4iox]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_herpesvirus_1 Human herpesvirus~~ 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UL15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 ~~Human herpesvirus~~ 1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UL15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 HHV-1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [http://www.ebi.ac.uk/pdbsum/4iox PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [http://pdbe.org/4iox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [http://www.ebi.ac.uk/pdbsum/4iox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iox ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4iox" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human herpesvirus~~ 1]]		[[Category: Hhv-1]]
	[[Category: Kamau, Y]]		[[Category: Kamau, Y]]
	[[Category: Sigamani, S Selvarajan]]		[[Category: Sigamani, S Selvarajan]]

OCA at 10:23, 25 December 2014

2014-12-25T10:23:52Z

← Older revision		Revision as of 10:23, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [http://www.ebi.ac.uk/pdbsum/4iox PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [http://www.ebi.ac.uk/pdbsum/4iox PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TRM3_HHV11 TRM3_HHV11]] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:42, 21 December 2014

2014-12-21T12:42:49Z

← Older revision		Revision as of 12:42, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4iox\| PDB=4iox \| SCENE= }}~~		==The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors==
	===The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors===		<StructureSection load='4iox' size='340' side='right' caption='[[4iox]], [[Resolution\|resolution]] 2.46Å' scene=''>
	~~{{ABSTRACT_PUBMED_23596306}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IOX FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UL15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iox RCSB], [http://www.ebi.ac.uk/pdbsum/4iox PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Herpes simplex virus type 1 (HSV-1), the prototypic member of herpesviruses, employs a virally encoded molecular machine called terminase to package viral dsDNA genome into a preformed protein shell. The terminase contains a large subunit that is thought to cleave concatemeric viral DNA during the packaging initiation and completion of each packaging cycle and supply energy to the packaging process via ATP hydrolysis. We have determined the X-ray structure of the C-terminal domain of the terminase large subunit pUL15 (pUL15C) from HSV-1. The structure shows a fold resembling those of bacteriophage terminases, RNases H, integrases, DNA polymerases, and topoisomerases, with an active site clustered with acidic residues. Docking analysis reveals a DNA-binding surface surrounded by flexible loops, indicating considerable conformational changes upon DNA binding. In vitro assay shows that pUL15C possesses non-sequence-specific, Mg2+-dependent nuclease activity. These results suggest that pUL15 uses an RNase-H-like, metal-ion-mediated catalysis mechanism for cleavage of viral concatemeric DNA. The structure reveals extra structural elements in addition to the RNase H-like fold core and variations in local architecture of the nuclease active site, which are conserved in herpesvirus terminases, bear great similarity to the phage T4 gp17, but are distinct from Podovirus and Siphovirus orthologs and cellular RNase H, delineating a new evolutionary lineage among a large family of eukaryotic viruses and simple and complex prokaryotic viruses.

	~~==Function==~~		The structure of the herpes simplex virus DNA-packaging terminase pUL15 nuclease domain suggests an evolutionary lineage among eukaryotic and prokaryotic viruses.,Sigamani SS, Zhao H, Kamau YN, Baines JD, Tang L J Virol. 2013 Apr 17. PMID:23596306<ref>PMID:23596306</ref>
	~~[[http://www.uniprot.org/uniprot/TRM3_HHV11 TRM3_HHV11]] Component~~ of the ~~molecular motor that translocates genomic DNA in empty capsid during~~ DNA packaging~~. Heterodimerizes with small~~ terminase ~~protein to be docked on capsid portal protein~~. ~~The latter forms a ring in which genomic DNA in translocated into the capsid~~. ~~May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4iox]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_herpesvirus_1 Human herpesvirus 1]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023596306</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Human herpesvirus 1]]		[[Category: Human herpesvirus 1]]
	[[Category: Kamau, Y.]]		[[Category: Kamau, Y]]
	[[Category: Sigamani, S Selvarajan.]]		[[Category: Sigamani, S Selvarajan]]
	[[Category: Tang, L.]]		[[Category: Tang, L]]
	[[Category: Zhao, H.]]		[[Category: Zhao, H]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 07:51, 19 June 2013

2013-06-19T07:51:33Z

← Older revision		Revision as of 07:51, 19 June 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA].		[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA].

			==Reference==
			<ref group="xtra">PMID:023596306</ref><references group="xtra"/><references/>
	[[Category: Human herpesvirus 1]]		[[Category: Human herpesvirus 1]]
	[[Category: Kamau, Y.]]		[[Category: Kamau, Y.]]

OCA at 07:34, 2 May 2013

2013-05-02T07:34:35Z

← Older revision		Revision as of 07:34, 2 May 2013
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4iox\| PDB=4iox \| SCENE= }}
			===The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors===
			{{ABSTRACT_PUBMED_23596306}}

	The ~~entry 4iox is ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/TRM3_HHV11 TRM3_HHV11]] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.

	~~Authors~~: ~~Selvarajan Sigamani, S~~.~~, Zhao, H~~., Kamau, Y., Tang, L.		==About this Structure==
			[[4iox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOX OCA].
	~~Description~~: ~~The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors~~		[[Category: Human herpesvirus 1]]
			[[Category: Kamau, Y.]]
			[[Category: Sigamani, S Selvarajan.]]
			[[Category: Tang, L.]]
			[[Category: Zhao, H.]]
			[[Category: Nuclease]]
			[[Category: Viral protein]]

OCA at 12:02, 30 January 2013

2013-01-30T12:02:35Z

← Older revision		Revision as of 12:02, 30 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4iox is ON HOLD		The entry 4iox is ON HOLD until Paper Publication

	Authors: Selvarajan Sigamani, S., ~~Haiyan~~, Z., ~~Yvonne~~, K., ~~Liang~~, T.		Authors: Selvarajan Sigamani, S., Zhao, H., Kamau, Y., Tang, L.

	Description: The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors		Description: The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors

OCA: Protected "4iox" [edit=sysop:move=sysop]

2013-01-16T08:28:21Z

Protected "4iox" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:28, 16 January 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4iox is ON HOLD Authors: Selvarajan Sigamani, S., Haiyan, Z., Yvonne, K., Liang, T. Description: The structure of the herpes simplex virus DNA-pack...

2013-01-16T08:28:19Z

New page: '''Unreleased structure''' The entry 4iox is ON HOLD Authors: Selvarajan Sigamani, S., Haiyan, Z., Yvonne, K., Liang, T. Description: The structure of the herpes simplex virus DNA-pack...

New page

'''Unreleased structure'''

The entry 4iox is ON HOLD

Authors: Selvarajan Sigamani, S., Haiyan, Z., Yvonne, K., Liang, T.

Description: The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors