4it2 - Revision history

OCA at 15:29, 20 September 2023

2023-09-20T15:29:53Z

← Older revision		Revision as of 15:29, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4it2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4it2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.097Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [https://pdbe.org/4it2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [https://www.ebi.ac.uk/pdbsum/4it2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [https://pdbe.org/4it2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [https://www.ebi.ac.uk/pdbsum/4it2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:09, 16 November 2022

2022-11-16T21:09:26Z

← Older revision		Revision as of 21:09, 16 November 2022
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	==Mn(III)-PPIX bound Tt H-NOX==		==Mn(III)-PPIX bound Tt H-NOX==
	<StructureSection load='4it2' size='340' side='right' caption='[[4it2]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4it2' size='340' side='right'caption='[[4it2]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4it2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~As_1~~.~~2430 As 1~~.~~2430~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4it2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u55\|1u55]], [[1u4h\|1u4h]], [[1u56\|1u56]], [[3eee\|3eee]], [[3sj5\|3sj5]], [[3m0b\|3m0b]]</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [https://pdbe.org/4it2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [https://www.ebi.ac.uk/pdbsum/4it2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it2 ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 AS 1.2430])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [~~http~~://pdbe.org/4it2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4it2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4it2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8RBX6_CALS4 Q8RBX6_CALS4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Chemotaxis protein\|Chemotaxis protein]]		*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~As 1 2430~~]]		[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
	[[Category: Klemm~~, P J~~]]		[[Category: Large Structures]]
	[[Category: Marletta~~, M A~~]]		[[Category: Klemm PJ]]
	[[Category: Phillips-Piro~~, C M~~]]		[[Category: Marletta MA]]
	[[Category: Raymond~~, K M~~]]		[[Category: Phillips-Piro CM]]
	[[Category: Winter~~, M B]]~~		[[Category: Raymond KM]]
	~~[[Category: O2-sensing heme domain]]~~		[[Category: Winter MB]]
	~~[[Category: Oxygen binding~~]]

OCA at 07:21, 23 December 2016

2016-12-23T07:21:07Z

← Older revision		Revision as of 07:21, 23 December 2016
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	==Mn(III)-PPIX bound Tt H-NOX==		==Mn(III)-PPIX bound Tt H-NOX==
	<StructureSection load='4it2' size='340' side='right' caption='[[4it2]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4it2' size='340' side='right' caption='[[4it2]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u55\|1u55]], [[1u4h\|1u4h]], [[1u56\|1u56]], [[3eee\|3eee]], [[3sj5\|3sj5]], [[3m0b\|3m0b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u55\|1u55]], [[1u4h\|1u4h]], [[1u56\|1u56]], [[3eee\|3eee]], [[3sj5\|3sj5]], [[3m0b\|3m0b]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 AS 1.2430])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 AS 1.2430])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [http://www.ebi.ac.uk/pdbsum/4it2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [http://pdbe.org/4it2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [http://www.ebi.ac.uk/pdbsum/4it2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4it2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4it2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:55, 10 December 2014

2014-12-10T16:55:47Z

← Older revision		Revision as of 16:55, 10 December 2014
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	[[~~Image~~:~~4it2~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Mn(III)-PPIX bound Tt H-NOX==
			<StructureSection load='4it2' size='340' side='right' caption='[[4it2]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4it2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IT2 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u55\|1u55]], [[1u4h\|1u4h]], [[1u56\|1u56]], [[3eee\|3eee]], [[3sj5\|3sj5]], [[3m0b\|3m0b]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 AS 1.2430])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4it2 RCSB], [http://www.ebi.ac.uk/pdbsum/4it2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Heme proteins are exquisitely tuned to carry out diverse biological functions while employing identical heme cofactors. Although heme protein properties are often altered through modification of the protein scaffold, protein function can be greatly expanded and diversified through replacement of the native heme with an unnatural porphyrin of interest. Thus, porphyrin substitution in proteins affords new opportunities to rationally tailor heme protein chemical properties for new biological applications. Here, a highly thermally stable Heme Nitric oxide/OXygen binding (H-NOX) protein is evaluated as a magnetic resonance imaging (MRI) contrast agent. T(1) and T(2) relaxivities measured for the H-NOX protein containing its native heme are compared to the protein substituted with unnatural manganese(II/III) and gadolinium(III) porphyrins. H-NOX proteins are found to provide unique porphyrin coordination environments and have enhanced relaxivities compared to commercial small-molecule agents. Porphyrin substitution is a promising strategy to encapsulate MRI-active metals in heme protein scaffolds for future imaging applications.

	~~{{STRUCTURE_4it2\| PDB=4it2 \| SCENE= }}~~		Porphyrin-Substituted H-NOX Proteins as High-Relaxivity MRI Contrast Agents.,Winter MB, Klemm PJ, Phillips-Piro CM, Raymond KN, Marletta MA Inorg Chem. 2013 Feb 8. PMID:23394479<ref>PMID:23394479</ref>

	~~===Mn(III)-PPIX bound Tt H-NOX===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23394479}}~~		==See Also==
			*[[Chemotaxis protein\|Chemotaxis protein]]
	==~~About this Structure~~==		== References ==
	[[~~4it2~~]] ~~is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA].		<references/>
	[[Category: ~~Caldanaerobacter subterraneus subsp. tengcongensis~~]]		__TOC__
	[[Category: Klemm, P J.]]		</StructureSection>
	[[Category: Marletta, M A.]]		[[Category: As 1 2430]]
	[[Category: Phillips-Piro, C M.]]		[[Category: Klemm, P J]]
	[[Category: Raymond, K M.]]		[[Category: Marletta, M A]]
	[[Category: Winter, M B.]]		[[Category: Phillips-Piro, C M]]
			[[Category: Raymond, K M]]
			[[Category: Winter, M B]]
	[[Category: O2-sensing heme domain]]		[[Category: O2-sensing heme domain]]
	[[Category: Oxygen binding]]		[[Category: Oxygen binding]]

OCA at 14:49, 27 February 2013

2013-02-27T14:49:00Z

← Older revision		Revision as of 14:49, 27 February 2013
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	~~'''Unreleased structure'''~~		[[Image:4it2.jpg\|left\|200px]]

	~~The entry~~ 4it2 ~~is ON HOLD~~		{{STRUCTURE_4it2\| PDB=4it2 \| SCENE= }}

	~~Authors: Winter, M.B., Klemm, P.J., Phillips~~-~~Piro, C.M., Raymond, K.M., Marletta, M.A.~~		===Mn(III)-PPIX bound Tt H-NOX===

	~~Description~~: ~~Mn(III)~~-~~PPIX bound TtH~~-~~NOX~~		{{ABSTRACT_PUBMED_23394479}}

			==About this Structure==
			[[4it2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT2 OCA].
			[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
			[[Category: Klemm, P J.]]
			[[Category: Marletta, M A.]]
			[[Category: Phillips-Piro, C M.]]
			[[Category: Raymond, K M.]]
			[[Category: Winter, M B.]]
			[[Category: O2-sensing heme domain]]
			[[Category: Oxygen binding]]

OCA: Protected "4it2" [edit=sysop:move=sysop]

2013-01-23T11:15:53Z

Protected "4it2" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:15, 23 January 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4it2 is ON HOLD Authors: Winter, M.B., Klemm, P.J., Phillips-Piro, C.M., Raymond, K.M., Marletta, M.A. Description: Mn(III)-PPIX bound TtH-NOX

2013-01-23T11:15:51Z

New page: '''Unreleased structure''' The entry 4it2 is ON HOLD Authors: Winter, M.B., Klemm, P.J., Phillips-Piro, C.M., Raymond, K.M., Marletta, M.A. Description: Mn(III)-PPIX bound TtH-NOX

New page

'''Unreleased structure'''

The entry 4it2 is ON HOLD

Authors: Winter, M.B., Klemm, P.J., Phillips-Piro, C.M., Raymond, K.M., Marletta, M.A.

Description: Mn(III)-PPIX bound TtH-NOX