4itd - Revision history

OCA at 08:53, 20 March 2024

2024-03-20T08:53:20Z

← Older revision		Revision as of 08:53, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene>, <scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene>, <scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [https://pdbe.org/4itd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [https://www.ebi.ac.uk/pdbsum/4itd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [https://pdbe.org/4itd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [https://www.ebi.ac.uk/pdbsum/4itd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itd ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	N-nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O6-carboxymethylguanine (O6-CMG) in DNA. O6-CMG has been identified in DNA derived from human colon tissue, and its occurrence has been linked to diets high in red and processed meats. By analogy to O6-methylguanine, O6-CMG is expected to be highly mutagenic, inducing G to A mutations during DNA replication that can increase the risk of gastrointestinal and other cancers. Two crystal structures of DNA dodecamers d(CGCG[O6-CMG]ATTCGCG) and d(CGC[O6-CMG]AATTCGCG) in complex with Hoechst33258 reveal that each can form a self-complementary duplex to retain the B-form conformation. Electron density maps clearly show that O6-CMG forms a Watson-Crick-type pair with thymine similar to the canonical A:T pair, and it forms a reversed wobble pair with cytosine. In situ structural modeling suggests that a DNA polymerase can accept the Watson-Crick-type pair of O6-CMG with thymine, but might also accept the reversed wobble pair of O6-CMG with cytosine. Thus, O6-CMG would permit the mis-incorporation of dTTP during DNA replication. Alternatively, the triphosphate that would be formed by carboxymethylation of the nucleotide triphosphate pool d[O6-CMG]TP might compete with dATP incorporation opposite thymine in a DNA template.

	Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.,Zhang F, Tsunoda M, Suzuki K, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Czarina Morishita E, Takenaka A Nucleic Acids Res. 2013 Apr 10. PMID:23580550<ref>PMID:23580550</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4itd" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:10, 16 November 2022

2022-11-16T21:10:07Z

← Older revision		Revision as of 21:10, 16 November 2022
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	<StructureSection load='4itd' size='340' side='right'caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4itd' size='340' side='right'caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ITD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene>, <scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene><~~/td~~></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [https://pdbe.org/4itd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [https://www.ebi.ac.uk/pdbsum/4itd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itd ProSAT]</span></td></tr>
	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~[[4ij0\|4ij0]]~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [~~http~~://pdbe.org/4itd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4itd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4itd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Millington~~, C L~~]]		[[Category: Millington CL]]
	[[Category: Morishita~~, E C~~]]		[[Category: Morishita EC]]
	[[Category: Suzuki, K]]		[[Category: Suzuki K]]
	[[Category: Takenaka, A]]		[[Category: Takenaka A]]
	[[Category: Tsunoda, M]]		[[Category: Tsunoda M]]
	[[Category: Wilkinson, O]]		[[Category: Wilkinson O]]
	[[Category: Williams~~, D M~~]]		[[Category: Williams DM]]
	[[Category: Zhang, F]]		[[Category: Zhang F]]
	~~[[Category: Damaged dna]]~~
	~~[[Category: Dna]]~~
	~~[[Category: Mutagenesis]]~~
	~~[[Category: O6-carboxymethylguanine~~]]

OCA at 08:02, 27 March 2019

2019-03-27T08:02:48Z

← Older revision		Revision as of 08:02, 27 March 2019
Line 1:		Line 1:

	==Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation==		==Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation==
	<StructureSection load='4itd' size='340' side='right' caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4itd' size='340' side='right'caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITD FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Millington, C L]]		[[Category: Millington, C L]]
	[[Category: Morishita, E C]]		[[Category: Morishita, E C]]

OCA at 09:35, 11 August 2016

2016-08-11T09:35:00Z

← Older revision		Revision as of 09:35, 11 August 2016
Line 1:		Line 1:

	==Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation==		==Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation==
	<StructureSection load='4itd' size='340' side='right' caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4itd' size='340' side='right' caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ij0\|4ij0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ij0\|4ij0]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [http://www.ebi.ac.uk/pdbsum/4itd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [http://pdbe.org/4itd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [http://www.ebi.ac.uk/pdbsum/4itd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4itd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4itd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:08, 4 January 2015

2015-01-04T13:08:43Z

← Older revision		Revision as of 13:08, 4 January 2015
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	~~{{STRUCTURE_4itd\| PDB=4itd \| SCENE= }}~~		==Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation==
	===Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation===		<StructureSection load='4itd' size='340' side='right' caption='[[4itd]], [[Resolution\|resolution]] 1.94Å' scene=''>
	~~{{ABSTRACT_PUBMED_23580550}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ij0\|4ij0]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4itd RCSB], [http://www.ebi.ac.uk/pdbsum/4itd PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			N-nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O6-carboxymethylguanine (O6-CMG) in DNA. O6-CMG has been identified in DNA derived from human colon tissue, and its occurrence has been linked to diets high in red and processed meats. By analogy to O6-methylguanine, O6-CMG is expected to be highly mutagenic, inducing G to A mutations during DNA replication that can increase the risk of gastrointestinal and other cancers. Two crystal structures of DNA dodecamers d(CGCG[O6-CMG]ATTCGCG) and d(CGC[O6-CMG]AATTCGCG) in complex with Hoechst33258 reveal that each can form a self-complementary duplex to retain the B-form conformation. Electron density maps clearly show that O6-CMG forms a Watson-Crick-type pair with thymine similar to the canonical A:T pair, and it forms a reversed wobble pair with cytosine. In situ structural modeling suggests that a DNA polymerase can accept the Watson-Crick-type pair of O6-CMG with thymine, but might also accept the reversed wobble pair of O6-CMG with cytosine. Thus, O6-CMG would permit the mis-incorporation of dTTP during DNA replication. Alternatively, the triphosphate that would be formed by carboxymethylation of the nucleotide triphosphate pool d[O6-CMG]TP might compete with dATP incorporation opposite thymine in a DNA template.

	~~==About this Structure==~~		Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.,Zhang F, Tsunoda M, Suzuki K, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Czarina Morishita E, Takenaka A Nucleic Acids Res. 2013 Apr 10. PMID:23580550<ref>PMID:23580550</ref>
	~~[[4itd]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4ITD OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023580550</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
	[[Category: Millington, C L.]]		== References ==
	[[Category: Morishita, E C.]]		<references/>
	[[Category: Suzuki, K.]]		__TOC__
	[[Category: Takenaka, A.]]		</StructureSection>
	[[Category: Tsunoda, M.]]		[[Category: Millington, C L]]
	[[Category: Wilkinson, O.]]		[[Category: Morishita, E C]]
	[[Category: Williams, D M.]]		[[Category: Suzuki, K]]
	[[Category: Zhang, F.]]		[[Category: Takenaka, A]]
			[[Category: Tsunoda, M]]
			[[Category: Wilkinson, O]]
			[[Category: Williams, D M]]
			[[Category: Zhang, F]]
	[[Category: Damaged dna]]		[[Category: Damaged dna]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Mutagenesis]]		[[Category: Mutagenesis]]
	[[Category: O6-carboxymethylguanine]]		[[Category: O6-carboxymethylguanine]]

OCA at 09:55, 19 March 2014

2014-03-19T09:55:11Z

← Older revision		Revision as of 09:55, 19 March 2014
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA].		[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA].

			==Reference==
			<ref group="xtra">PMID:023580550</ref><references group="xtra"/><references/>
	[[Category: Millington, C L.]]		[[Category: Millington, C L.]]
	[[Category: Morishita, E C.]]		[[Category: Morishita, E C.]]

OCA at 07:45, 8 May 2013

2013-05-08T07:45:12Z

← Older revision		Revision as of 07:45, 8 May 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4itd\| PDB=4itd \| SCENE= }}
			===Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation===
			{{ABSTRACT_PUBMED_23580550}}

	~~The entry~~ 4itd is ~~ON HOLD~~		==About this Structure==
			[[4itd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITD OCA].
	~~Authors~~: ~~Zhang~~, F., Suzuki, K., Tsunoda, M., Wilkinson, O.~~, Millington, C.L.,~~ Williams, D.M., ~~Morishita, E.C., Takenaka, A~~.		[[Category: Millington, C L.]]
			[[Category: Morishita, E C.]]
	~~Description~~: ~~Structures of DNA duplexes containing~~ O6-carboxymethylguanine~~, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation~~		[[Category: Suzuki, K.]]
			[[Category: Takenaka, A.]]
			[[Category: Tsunoda, M.]]
			[[Category: Wilkinson, O.]]
			[[Category: Williams, D M.]]
			[[Category: Zhang, F.]]
			[[Category: Damaged dna]]
			[[Category: Dna]]
			[[Category: Mutagenesis]]
			[[Category: O6-carboxymethylguanine]]

OCA at 12:04, 30 January 2013

2013-01-30T12:04:01Z

← Older revision		Revision as of 12:04, 30 January 2013
Line 5:		Line 5:
	Authors: Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A.		Authors: Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A.

	Description: Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation.		Description: Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation

OCA: Protected "4itd" [edit=sysop:move=sysop]

2013-01-23T11:16:14Z

Protected "4itd" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:16, 23 January 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4itd is ON HOLD Authors: Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A. Descrip...

2013-01-23T11:16:13Z

New page: '''Unreleased structure''' The entry 4itd is ON HOLD Authors: Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A. Descrip...

New page

'''Unreleased structure'''

The entry 4itd is ON HOLD

Authors: Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A.

Description: Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation.