4ith - Revision history

OCA at 15:30, 20 September 2023

2023-09-20T15:30:08Z

← Older revision		Revision as of 15:30, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [https://pdbe.org/4ith PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [https://www.ebi.ac.uk/pdbsum/4ith PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ith ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [https://pdbe.org/4ith PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [https://www.ebi.ac.uk/pdbsum/4ith PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ith ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:10, 16 November 2022

2022-11-16T21:10:24Z

← Older revision		Revision as of 21:10, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of RIP1 kinase in complex with necrostatin-1 analog==		==Crystal structure of RIP1 kinase in complex with necrostatin-1 analog==
	<StructureSection load='4ith' size='340' side='right' caption='[[4ith]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4ith' size='340' side='right'caption='[[4ith]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ITH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iti\|4iti]], [[4itj\|4itj]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [https://pdbe.org/4ith PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [https://www.ebi.ac.uk/pdbsum/4ith PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ith ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIPK1, RIP, RIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [~~http~~://pdbe.org/4ith PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ith PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ith ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref>		[https://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Non-specific serine/threonine protein kinase~~]]		[[Category: Large Structures]]
	[[Category: Liu, Y]]		[[Category: Liu Y]]
	[[Category: Peng, W]]		[[Category: Peng W]]
	[[Category: Shi, Y]]		[[Category: Shi Y]]
	[[Category: Xie, T]]		[[Category: Xie T]]
	[[Category: Yan, C]]		[[Category: Yan C]]
	~~[[Category: Alpha/beta]]~~
	~~[[Category: Kinase]]~~
	~~[[Category: Necroptosis]]~~
	~~[[Category: Necrostatin]]~~
	~~[[Category: Rip1 kinase]]~~
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 11:34, 4 August 2016

2016-08-04T11:34:54Z

← Older revision		Revision as of 11:34, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of RIP1 kinase in complex with necrostatin-1 analog==		==Crystal structure of RIP1 kinase in complex with necrostatin-1 analog==
	<StructureSection load='4ith' size='340' side='right' caption='[[4ith]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4ith' size='340' side='right' caption='[[4ith]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iti\|4iti]], [[4itj\|4itj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iti\|4iti]], [[4itj\|4itj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIPK1, RIP, RIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIPK1, RIP, RIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [http://www.ebi.ac.uk/pdbsum/4ith PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [http://pdbe.org/4ith PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [http://www.ebi.ac.uk/pdbsum/4ith PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ith ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ith" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Liu, Y]]		[[Category: Liu, Y]]

OCA at 08:53, 25 December 2014

2014-12-25T08:53:33Z

← Older revision		Revision as of 08:53, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4ith~~\| ~~PDB~~=4ith \| ~~SCENE~~= }}		==Crystal structure of RIP1 kinase in complex with necrostatin-1 analog==
	===~~Crystal structure~~ of ~~RIP1~~ kinase in complex with ~~necrostatin~~-~~1 analog~~===		<StructureSection load='4ith' size='340' side='right' caption='[[4ith]], [[Resolution\|resolution]] 2.25Å' scene=''>
	~~{{ABSTRACT_PUBMED_23473668}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITH FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCM:(5R)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE'>RCM</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iti\|4iti]], [[4itj\|4itj]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIPK1, RIP, RIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ith OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ith RCSB], [http://www.ebi.ac.uk/pdbsum/4ith PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Necroptosis is a cellular mechanism that mediates necrotic cell death. The receptor-interacting serine/threonine protein kinase 1 (RIP1) is an essential upstream signaling molecule in tumor-necrosis-factor-alpha-induced necroptosis. Necrostatins, a series of small-molecule inhibitors, suppress necroptosis by specifically inhibiting RIP1 kinase activity. Both RIP1 structure and the mechanisms by which necrostatins inhibit RIP1 remain unknown. Here, we report the crystal structures of the RIP1 kinase domain individually bound to necrostatin-1 analog, necrostatin-3 analog, and necrostatin-4. Necrostatin, caged in a hydrophobic pocket between the N- and C-lobes of the kinase domain, stabilizes RIP1 in an inactive conformation through interactions with highly conserved amino acids in the activation loop and the surrounding structural elements. Structural comparison of RIP1 with the inhibitor-bound oncogenic kinase B-RAF reveals partially overlapping binding sites for necrostatin and for the anticancer compound PLX4032. Our study provides a structural basis for RIP1 inhibition by necrostatins and offers insights into potential structure-based drug design.

	~~==Function==~~		Structural Basis of RIP1 Inhibition by Necrostatins.,Xie T, Peng W, Liu Y, Yan C, Maki J, Degterev A, Yuan J, Shi Y Structure. 2013 Mar 5;21(3):493-9. doi: 10.1016/j.str.2013.01.016. PMID:23473668<ref>PMID:23473668</ref>
	~~[[http://www.uniprot~~.~~org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation~~, ~~activation of pathogen recognition receptors (PRRs)~~, ~~and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines~~, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, ~~which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO~~, ~~the regulatory subunit of the IKK complex~~, ~~a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association~~, ~~in particular~~, ~~forms a necrosis~~-~~inducing complex~~.~~<ref>PMID~~:~~11101870<~~/~~ref><ref>~~PMID:~~19524513</ref>~~<ref>PMID:~~19524512~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4ith]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Liu, Y.]]		[[Category: Liu, Y]]
	[[Category: Peng, W.]]		[[Category: Peng, W]]
	[[Category: Shi, Y.]]		[[Category: Shi, Y]]
	[[Category: Xie, T.]]		[[Category: Xie, T]]
	[[Category: Yan, C.]]		[[Category: Yan, C]]
	[[Category: Alpha/beta]]		[[Category: Alpha/beta]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 07:39, 27 March 2013

2013-03-27T07:39:07Z

← Older revision		Revision as of 07:39, 27 March 2013
Line 1:		Line 1:
	{{STRUCTURE_4ith\| PDB=4ith \| SCENE= }}		{{STRUCTURE_4ith\| PDB=4ith \| SCENE= }}
	===Crystal structure of RIP1 kinase in complex with necrostatin-1 analog===		===Crystal structure of RIP1 kinase in complex with necrostatin-1 analog===
			{{ABSTRACT_PUBMED_23473668}}

			==Function==
			[[http://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref><ref>PMID:19524513</ref><ref>PMID:19524512</ref>

	==About this Structure==		==About this Structure==
	[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA].		[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 10:31, 13 March 2013

2013-03-13T10:31:50Z

← Older revision		Revision as of 10:31, 13 March 2013
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	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4ith\| PDB=4ith \| SCENE= }}
			===Crystal structure of RIP1 kinase in complex with necrostatin-1 analog===

	~~The entry~~ 4ith is ~~ON HOLD until Paper Publication~~		==About this Structure==
			[[4ith]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITH OCA].
	~~Authors~~: ~~Xie~~, T., Peng, W.~~, Liu~~, Y., Yan, C.~~, Shi, Y.~~		[[Category: Homo sapiens]]
			[[Category: Non-specific serine/threonine protein kinase]]
	~~Description~~: ~~Crystal structure of RIP1~~ kinase in complex ~~with necrostatin-1 analog~~		[[Category: Liu, Y.]]
			[[Category: Peng, W.]]
			[[Category: Shi, Y.]]
			[[Category: Xie, T.]]
			[[Category: Yan, C.]]
			[[Category: Alpha/beta]]
			[[Category: Kinase]]
			[[Category: Necroptosis]]
			[[Category: Necrostatin]]
			[[Category: Rip1 kinase]]
			[[Category: Transferase-transferase inhibitor complex]]

OCA at 14:20, 27 February 2013

2013-02-27T14:20:34Z

← Older revision		Revision as of 14:20, 27 February 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4ith is ON HOLD		The entry 4ith is ON HOLD until Paper Publication

	Authors: Xie, T., Peng, W., Liu, Y., Yan, C., Shi, Y.		Authors: Xie, T., Peng, W., Liu, Y., Yan, C., Shi, Y.

	Description: Crystal structure of a kinase with ~~an inhibitor~~		Description: Crystal structure of RIP1 kinase in complex with necrostatin-1 analog

OCA: Protected "4ith" [edit=sysop:move=sysop]

2013-01-30T12:04:10Z

Protected "4ith" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:04, 30 January 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ith is ON HOLD Authors: Xie, T., Peng, W., Liu, Y., Yan, C., Shi, Y. Description: Crystal structure of a kinase with an inhibitor

2013-01-30T12:04:09Z

New page: '''Unreleased structure''' The entry 4ith is ON HOLD Authors: Xie, T., Peng, W., Liu, Y., Yan, C., Shi, Y. Description: Crystal structure of a kinase with an inhibitor

New page

'''Unreleased structure'''

The entry 4ith is ON HOLD

Authors: Xie, T., Peng, W., Liu, Y., Yan, C., Shi, Y.

Description: Crystal structure of a kinase with an inhibitor