4j4e - Revision history

OCA at 15:36, 20 September 2023

2023-09-20T15:36:03Z

← Older revision		Revision as of 15:36, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [https://pdbe.org/4j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [https://www.ebi.ac.uk/pdbsum/4j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4e ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [https://pdbe.org/4j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [https://www.ebi.ac.uk/pdbsum/4j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:31, 16 November 2022

2022-11-16T21:31:51Z

← Older revision		Revision as of 21:31, 16 November 2022
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	<StructureSection load='4j4e' size='340' side='right'caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4j4e' size='340' side='right'caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4E FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4d\|4j4d]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [https://pdbe.org/4j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [https://www.ebi.ac.uk/pdbsum/4j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4e ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [~~http~~://pdbe.org/4j4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>		[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Anabaena variabilis var. ellipsospora]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Gronenborn, A M~~]]		[[Category: Nostoc ellipsosporum]]
	[[Category: ~~Koharudin, L M.I~~]]		[[Category: Gronenborn AM]]
	[[Category: ~~Liu, L~~]]		[[Category: Koharudin LMI]]
	[[Category: ~~Antiviral protein]]~~		[[Category: Liu L]]
	~~[[Category: Carbohydrate binding protein]]~~
	~~[[Category: Cvnh fold]]~~
	~~[[Category: Sugar binding protein~~]]

OCA at 08:44, 3 April 2019

2019-04-03T08:44:06Z

← Older revision		Revision as of 08:44, 3 April 2019
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	==Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group==		==Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group==
	<StructureSection load='4j4e' size='340' side='right' caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4j4e' size='340' side='right'caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4E FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Anabaena variabilis var. ellipsospora]]		[[Category: Anabaena variabilis var. ellipsospora]]
			[[Category: Large Structures]]
	[[Category: Gronenborn, A M]]		[[Category: Gronenborn, A M]]
	[[Category: Koharudin, L M.I]]		[[Category: Koharudin, L M.I]]

OCA at 12:15, 4 August 2016

2016-08-04T12:15:27Z

← Older revision		Revision as of 12:15, 4 August 2016
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	==Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group==		==Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group==
	<StructureSection load='4j4e' size='340' side='right' caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4j4e' size='340' side='right' caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Nostoc_ellipsosporum Nostoc ellipsosporum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4E FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4d\|4j4d]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4d\|4j4d]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [http://www.ebi.ac.uk/pdbsum/4j4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [http://pdbe.org/4j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [http://www.ebi.ac.uk/pdbsum/4j4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4j4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Nostoc ellipsosporum~~]]		[[Category: Anabaena variabilis var. ellipsospora]]
	[[Category: Gronenborn, A M]]		[[Category: Gronenborn, A M]]
	[[Category: Koharudin, L M.I]]		[[Category: Koharudin, L M.I]]

OCA at 09:13, 25 December 2014

2014-12-25T09:13:13Z

← Older revision		Revision as of 09:13, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [http://www.ebi.ac.uk/pdbsum/4j4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [http://www.ebi.ac.uk/pdbsum/4j4e PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:15, 21 December 2014

2014-12-21T12:15:51Z

← Older revision		Revision as of 12:15, 21 December 2014
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	~~{{STRUCTURE_4j4e\| PDB=4j4e \| SCENE= }}~~		==Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group==
	===Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group===		<StructureSection load='4j4e' size='340' side='right' caption='[[4j4e]], [[Resolution\|resolution]] 2.40Å' scene=''>
	~~{{ABSTRACT_PUBMED_23610431}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4E FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4d\|4j4d]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4e RCSB], [http://www.ebi.ac.uk/pdbsum/4j4e PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Although it has long been established that the amino acid sequence encodes the fold of a protein, how individual proteins arrive at their final conformation is still difficult to predict, especially for oligomeric structures. Here, we present a comprehensive characterization of oligomeric species of cyanovirin-N that all are formed by a polypeptide chain with the identical amino acid sequence. Structures of the oligomers were determined by X-ray crystallography, and each one exhibits 3D domain swapping. One unique 3D domain-swapped structure is observed for the trimer, while for both dimer and tetramer, two different 3D domain-swapped structures were obtained. In addition to the previously identified hinge-loop region of the 3D domain-swapped dimer, which resides between strands beta5 and beta6 in the middle of the polypeptide sequence, another hinge-loop region is observed between strands beta7 and beta8 in the structures. Plasticity in these two regions allows for variability in dihedral angles and concomitant differences in chain conformation that results in the differently 3D domain-swapped multimers. Based on all of the different structures, we propose possible folding pathways for this protein. Altogether, our results illuminate the amazing ability of cyanovirin-N to proceed down different folding paths and provide general insights into oligomer formation via 3D domain swapping.

	~~==Function==~~		Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates.,Koharudin LM, Liu L, Gronenborn AM Proc Natl Acad Sci U S A. 2013 Apr 22. PMID:23610431<ref>PMID:23610431</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin~~.~~<ref>~~PMID:~~9210678</ref>~~ <ref>PMID:~~12678493~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4j4e]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023610431</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
	[[Category: Gronenborn, A M.]]		[[Category: Gronenborn, A M]]
	[[Category: Koharudin, L M.I.]]		[[Category: Koharudin, L M.I]]
	[[Category: Liu, L.]]		[[Category: Liu, L]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
	[[Category: Cvnh fold]]		[[Category: Cvnh fold]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 06:40, 20 June 2013

2013-06-20T06:40:25Z

← Older revision		Revision as of 06:40, 20 June 2013
Line 10:		Line 10:

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:023610431</ref><references group="xtra"/><references/>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
	[[Category: Gronenborn, A M.]]		[[Category: Gronenborn, A M.]]

OCA at 06:53, 8 May 2013

2013-05-08T06:53:50Z

← Older revision		Revision as of 06:53, 8 May 2013
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	{{STRUCTURE_4j4e\| PDB=4j4e \| SCENE= }}		{{STRUCTURE_4j4e\| PDB=4j4e \| SCENE= }}
	===Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group===		===Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group===
			{{ABSTRACT_PUBMED_23610431}}

	==Function==		==Function==

OCA at 01:52, 4 April 2013

2013-04-04T01:52:46Z

← Older revision		Revision as of 01:52, 4 April 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4j4e\| PDB=4j4e \| SCENE= }}
			===Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group===

	~~The entry 4j4e is ON HOLD~~		==Function==
			[[http://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>

	~~Authors~~: ~~Koharudin, L~~.M.I.~~, Liu, L~~.~~, Gronenborn, A~~.M.		==About this Structure==
			[[4j4e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4E OCA].

	~~Description~~: ~~Structure of P51G Cyanovirin-N swapped trimer in the P212121 space group~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Nostoc ellipsosporum]]
			[[Category: Gronenborn, A M.]]
			[[Category: Koharudin, L M.I.]]
			[[Category: Liu, L.]]
			[[Category: Antiviral protein]]
			[[Category: Carbohydrate binding protein]]
			[[Category: Cvnh fold]]
			[[Category: Sugar binding protein]]

OCA: Protected "4j4e" [edit=sysop:move=sysop]

2013-02-13T10:12:28Z

Protected "4j4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:12, 13 February 2013
(No difference)